Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer
The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2011 by National Cancer Institute (NCI).
Recruitment status was Active, not recruiting
Recruitment status was Active, not recruiting
Sponsor:
Radiation Therapy Oncology Group
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00365105
First received: August 16, 2006
Last updated: June 26, 2012
Last verified: February 2011
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Purpose
RATIONALE: Zoledronate, vitamin D and calcium may prevent or delay bone pain and other symptoms caused by bone metastases. It is not yet known whether giving zoledronate together with vitamin D and calcium is more effective with or without strontium 89 or samarium 153 in treating patients with bone metastases from prostate cancer, lung cancer, or breast cancer.
PURPOSE: This randomized phase III trial is studying zoledronate, vitamin D, and calcium to see how well they work compared to zoledronate, vitamin D, calcium, and either strontium 89 or samarium 153 in preventing or delaying bone problems in patients with bone metastases from prostate cancer, lung cancer, or breast cancer.
| Condition | Intervention | Phase |
|---|---|---|
|
Breast Cancer Lung Cancer Metastatic Cancer Pain Prostate Cancer |
Dietary Supplement: calcium carbonate Dietary Supplement: calcium citrate Dietary Supplement: calcium glucarate Dietary Supplement: vitamin D Drug: calcium gluconate Drug: zoledronic acid Radiation: samarium Sm 153 lexidronam pentasodium Radiation: strontium chloride Sr 89 |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Masking: Open Label Primary Purpose: Supportive Care |
| Official Title: | Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases From Lung, Breast, and Prostate Cancer |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
Drug Information available for:
Calcium Gluconate
Calcium carbonate
Vitamin D
Chlorine
Strontium chloride Sr 89
Zoledronic acid
Samarium Sm 153 lexidronam pentasodium
Quadramet
U.S. FDA Resources
Further study details as provided by National Cancer Institute (NCI):
Primary Outcome Measures:
- Time to development of a malignant skeletal-related events (SRE) [ Designated as safety issue: No ]
Secondary Outcome Measures:
- SRE rate at 1 year [ Designated as safety issue: No ]
- Overall survival [ Designated as safety issue: No ]
- Changes in quality of life as measured by FACT-G [ Designated as safety issue: No ]
- Changes in pain control as measured by Brief Pain Inventory (BPI) [ Designated as safety issue: No ]
- Utility and cost effectiveness of the use of radiopharmaceuticals and bisphosphonates as measured by the EuroQol-5 Dimension (EQ-5D) [ Designated as safety issue: No ]
| Estimated Enrollment: | 352 |
| Study Start Date: | July 2006 |
| Estimated Primary Completion Date: | March 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: Arm I
Patients receive zoledronate IV over 15 minutes once a month. Patients also receive oral vitamin D and oral calcium once daily. Treatment continues in the absence of disease progression or unacceptable toxicity.
|
Dietary Supplement: calcium carbonate
Zoledronic acid given IV; vitamin D and calcium given orally
Dietary Supplement: calcium citrate
Zoledronic acid given IV; vitamin D and calcium given orally
Dietary Supplement: calcium glucarate
Zoledronic acid given IV; vitamin D and calcium given orally
Dietary Supplement: vitamin D
Zoledronic acid given IV; vitamin D and calcium given orally
Drug: calcium gluconate
Zoledronic acid given IV; vitamin D and calcium given orally
Drug: zoledronic acid
Zoledronic acid given IV; vitamin D and calcium given orally
|
|
Experimental: Arm II
Patients receive zoledronate, vitamin D, and calcium as in arm I. Within 6 weeks of beginning study treatment, patients also receive a single dose of either strontium chloride Sr 89 IV or samarium Sm 153 lexidronam pentasodium IV.
|
Dietary Supplement: calcium carbonate
Zoledronic acid given IV; vitamin D and calcium given orally
Dietary Supplement: calcium citrate
Zoledronic acid given IV; vitamin D and calcium given orally
Dietary Supplement: calcium glucarate
Zoledronic acid given IV; vitamin D and calcium given orally
Dietary Supplement: vitamin D
Zoledronic acid given IV; vitamin D and calcium given orally
Drug: calcium gluconate
Zoledronic acid given IV; vitamin D and calcium given orally
Drug: zoledronic acid
Zoledronic acid given IV; vitamin D and calcium given orally
Radiation: samarium Sm 153 lexidronam pentasodium
Given IV
Radiation: strontium chloride Sr 89
Given IV
|
Detailed Description:
OBJECTIVES:
Primary
- Compare the efficacy of zoledronate, vitamin D, and calcium with or without strontium chloride Sr 89 or samarium Sm 153 lexidronam pentasodium, in terms of preventing or delaying the time to development of malignant skeletal-related events (SREs) (defined as a pathological bone fracture, spinal cord compression, surgery to bone, or radiation to bone) in patients with bone metastases secondary to prostate, lung, or breast cancer.
Secondary
- Compare the rate of SREs at 1 year in patients treated with these regimens.
- Compare overall survival of patients treated with these regimens.
- Compare quality of life of patients treated with these regimens.
- Compare the effect of these regimens on pain control in these patients.
- Evaluate resource utilization and cost effectiveness of these regimens.
OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to primary disease site (prostate vs breast vs lung) and number of bone metastases (≤ 2 vs > 2). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive zoledronate IV over 15 minutes once a month. Patients also receive oral vitamin D and oral calcium once daily. Treatment continues in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive zoledronate, vitamin D, and calcium as in arm I. Within 6 weeks of beginning study treatment, patients also receive a single dose of either strontium chloride Sr 89 IV or samarium Sm 153 lexidronam pentasodium IV.
Quality of life and pain are assessed at baseline and then at 1, 3, 6, and 12 months from start of protocol treatment.
After completion of study treatment, patients are followed every 6 months.
PROJECTED ACCRUAL: A total of 352 patients will be accrued for this study.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed lung, breast, or prostate cancer
Bone metastases, meeting both of the following criteria:
- Must be visible on bone scan performed within the past 4 weeks
- No painful bone metastases unless successfully treated (i.e., by external-beam irradiation) prior to study entry AND the patient has stable pain* for at least 2 weeks after that treatment NOTE: *Stable pain is defined as a patient response of 1, 2, or 3 on Questions 4 and 5 of The Brief Pain Inventory (BPI)
- No untreated or symptomatic brain metastases
- No spinal cord compression
- Hormone receptor status not specified
PATIENT CHARACTERISTICS:
- Zubrod performance status (PS) 0-2 (for patients with primary breast or prostate cancer) OR Zubrod PS 0-1 (for patients with primary lung cancer)
- WBC ≥ 2,400/mm³
- Absolute neutrophil count ≥ 1,800/mm³
- Platelet count ≥ 60,000/mm³
- Hemoglobin ≥ 8.0 g/dL (transfusion allowed)
- Creatinine < 3.0 mg/dL
- Bilirubin < 2.5 mg/dL
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No uncontrolled congestive heart failure within the past 6 months
- No hypertension refractory to treatment within the past 6 months
- No symptomatic coronary artery disease within the past 6 months
No current, active dental problems within the past 4 weeks, including any of the following:
- Infection of the teeth or jawbone (maxilla or mandible)
- Dental or fixture trauma
- Prior or current diagnosis of osteonecrosis of the jaw
- Exposed bone in the mouth
- Slow healing after dental procedures
No known AIDS
- HIV testing is not required
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Prior oral bisphosphonate therapy (i.e. alendronate sodium or similar) allowed
- No prior IV bisphosphonates for a treatment duration of > 6 months
- At least 2 weeks since prior calcitonin, mithramycin, or gallium nitrate
- At least 2 weeks since prior external-beam radiotherapy
- At least 6 weeks since prior and no concurrent dental surgery (e.g., extractions or implants)
- No prior radioisotope therapy for bone metastasis
Concurrent systemic chemotherapy* or hormonal therapy allowed
- Chemotherapy and/or hormonal therapy should not be changed within 14 days prior to start of protocol treatment (arm I)
- No other concurrent bisphosphonate NOTE: *Chemotherapy must be held 2 weeks before and for at least 2 weeks after radiopharmaceutical administration (arm II)
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00365105
Hide Study Locations
Hide Study LocationsLocations
| United States, Alabama | |
| Providence Cancer Center at Providence Hospital | |
| Mobile, Alabama, United States, 36608 | |
| United States, California | |
| Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center | |
| Burbank, California, United States, 91505 | |
| Mercy Cancer Center at Mercy San Juan Medical Center | |
| Carmichael, California, United States, 95608 | |
| USC/Norris Comprehensive Cancer Center and Hospital | |
| Los Angeles, California, United States, 90089-9181 | |
| Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center | |
| Pomona, California, United States, 91767 | |
| Radiation Oncology Center - Roseville | |
| Roseville, California, United States, 95661 | |
| Radiological Associates of Sacramento Medical Group, Incorporated | |
| Sacramento, California, United States, 95815 | |
| General Robert Huyser Cancer Center at David Grant Medical Center | |
| Travis AFB, California, United States, 94535-1800 | |
| United States, Florida | |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | |
| Fort Lauderdale, Florida, United States, 33308 | |
| Integrated Community Oncology Network at Southside Cancer Center | |
| Jacksonville, Florida, United States, 32207 | |
| Baptist Cancer Institute - Jacksonville | |
| Jacksonville, Florida, United States, 32207 | |
| Integrated Community Oncology Network | |
| Jacksonville Beach, Florida, United States, 32250 | |
| Baptist Medical Center South | |
| Jascksonville, Florida, United States, 32258 | |
| Miami Cancer Center at Mercy Hospital | |
| Miami, Florida, United States, 33133 | |
| CCOP - Mount Sinai Medical Center | |
| Miami Beach, Florida, United States, 33140 | |
| Integrated Community Oncology Network - Orange Park | |
| Orange Park, Florida, United States, 32073 | |
| Florida Cancer Center - Palatka | |
| Palatka, Florida, United States, 32177 | |
| Bay Medical | |
| Panama City, Florida, United States, 32401 | |
| Flagler Cancer Center | |
| Saint Augustine, Florida, United States, 32086 | |
| H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | |
| Tampa, Florida, United States, 33612-9497 | |
| United States, Georgia | |
| John B. Amos Cancer Center | |
| Columbus, Georgia, United States, 31904 | |
| Northeast Georgia Medical Center | |
| Gainesville, Georgia, United States, 30501 | |
| United States, Illinois | |
| Northwest Community Hospital | |
| Arlington Heights, Illinois, United States, 60005 | |
| Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital | |
| Downers Grove, Illinois, United States, 60515-1500 | |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | |
| Harvey, Illinois, United States, 60426 | |
| Veterans Affairs Medical Center - Hines | |
| Hines, Illinois, United States, 60141 | |
| Advocate Christ Medical Center | |
| Oak Lawn, Illinois, United States, 60453-2699 | |
| Advocate Lutheran General Cancer Care Center | |
| Park Ridge, Illinois, United States, 60068-1174 | |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | |
| Peoria, Illinois, United States, 61615 | |
| Cancer Institute at St. John's Hospital | |
| Springfield, Illinois, United States, 62702 | |
| CCOP - Carle Cancer Center | |
| Urbana, Illinois, United States, 61801 | |
| United States, Indiana | |
| Center for Cancer Care at Goshen General Hospital | |
| Goshen, Indiana, United States, 46526 | |
| Cancer Center at Ball Memorial Hospital | |
| Muncie, Indiana, United States, 47303-3499 | |
| CCOP - Northern Indiana CR Consortium | |
| South Bend, Indiana, United States, 46601 | |
| United States, Iowa | |
| McFarland Clinic, PC | |
| Ames, Iowa, United States, 50010 | |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | |
| Des Moines, Iowa, United States, 50309 | |
| CCOP - Iowa Oncology Research Association | |
| Des Moines, Iowa, United States, 50309 | |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | |
| Des Moines, Iowa, United States, 50309 | |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | |
| Des Moines, Iowa, United States, 50314 | |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | |
| Des Moines, Iowa, United States, 50314 | |
| Siouxland Hematology-Oncology Associates, LLP | |
| Sioux City, Iowa, United States, 51101 | |
| United States, Kansas | |
| Lawrence Memorial Hospital | |
| Lawrence, Kansas, United States, 66044 | |
| CCOP - Wichita | |
| Wichita, Kansas, United States, 67214 | |
| United States, Kentucky | |
| Central Baptist Hospital | |
| Lexington, Kentucky, United States, 40503-9985 | |
| United States, Louisiana | |
| Tulane Cancer Center Office of Clinical Research | |
| Alexandria, Louisiana, United States, 71315-3198 | |
| United States, Maine | |
| Central Maine Comprehensive Cancer Center at Central Maine Medical Center | |
| Lewiston, Maine, United States, 04240 | |
| United States, Maryland | |
| St. Agnes Hospital Cancer Center | |
| Baltimore, Maryland, United States, 21229 | |
| United States, Massachusetts | |
| Hudner Oncology Center at Saint Anne's Hospital - Fall River | |
| Fall River, Massachusetts, United States, 02721 | |
| Cape Cod Hospital | |
| Hyannis, Massachusetts, United States, 02601 | |
| United States, Michigan | |
| Saint Joseph Mercy Cancer Center | |
| Ann Arbor, Michigan, United States, 48106-0995 | |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |
| Dearborn, Michigan, United States, 48123-2500 | |
| Josephine Ford Cancer Center at Henry Ford Hospital | |
| Detroit, Michigan, United States, 48202 | |
| Genesys Hurley Cancer Institute | |
| Flint, Michigan, United States, 48503 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | |
| Grosse Pointe Woods, Michigan, United States, 48236 | |
| Dickinson County Healthcare System | |
| Iron Mountain, Michigan, United States, 49801 | |
| Bronson Methodist Hospital | |
| Kalamazoo, Michigan, United States, 49007 | |
| West Michigan Cancer Center | |
| Kalamazoo, Michigan, United States, 49007-3731 | |
| Sparrow Regional Cancer Center | |
| Lansing, Michigan, United States, 48912-1811 | |
| St. John Macomb Hospital | |
| Warren, Michigan, United States, 48093 | |
| United States, Minnesota | |
| CentraCare Clinic - River Campus | |
| Saint Cloud, Minnesota, United States, 56303 | |
| United States, Mississippi | |
| Regional Cancer Center at Singing River Hospital | |
| Pascagoula, Mississippi, United States, 39581 | |
| United States, Missouri | |
| CCOP - Kansas City | |
| Kansas City, Missouri, United States, 64131 | |
| Truman Medical Center - Hospital Hill | |
| Kansas City, Missouri, United States, 64108 | |
| St. John's Regional Health Center | |
| Springfield, Missouri, United States, 65804 | |
| Hulston Cancer Center at Cox Medical Center South | |
| Springfield, Missouri, United States, 65807 | |
| United States, Montana | |
| Billings Clinic - Downtown | |
| Billings, Montana, United States, 59107-7000 | |
| CCOP - Montana Cancer Consortium | |
| Billings, Montana, United States, 59101 | |
| Northern Rockies Radiation Oncology Center | |
| Billings, Montana, United States, 59101 | |
| Great Falls Clinic - Main Facility | |
| Great Falls, Montana, United States, 59405 | |
| United States, Nebraska | |
| Good Samaritan Cancer Center at Good Samaritan Hospital | |
| Kearney, Nebraska, United States, 68848-1990 | |
| United States, New Jersey | |
| Princeton Radiation Oncology Center | |
| Jamesburg, New Jersey, United States, 08831 | |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | |
| Marlton, New Jersey, United States, 08053 | |
| University Medical Center at Princeton | |
| Princeton, New Jersey, United States, 08540-3298 | |
| Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | |
| Vineland, New Jersey, United States, 08360 | |
| Cancer Institute of New Jersey at Cooper - Voorhees | |
| Voorhees, New Jersey, United States, 08043 | |
| United States, New Mexico | |
| New Mexico Cancer Center | |
| Albuquerque, New Mexico, United States, 87109 | |
| United States, New York | |
| New York Methodist Hospital | |
| Brooklyn, New York, United States, 11215 | |
| Sands Cancer Center | |
| Canandiaqua, New York, United States, 14424 | |
| Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center | |
| Plattsburgh, New York, United States, 12901 | |
| James P. Wilmot Cancer Center at University of Rochester Medical Center | |
| Rochester, New York, United States, 14642 | |
| Highland Hospital of Rochester | |
| Rochester, New York, United States, 14620 | |
| Lipson Cancer and Blood Center at Rochester General Hospital | |
| Rochester, New York, United States, 14621 | |
| University Radiation Oncology at Parkridge Hospital | |
| Rochester, New York, United States, 14626 | |
| United States, North Carolina | |
| Mission Hospitals - Memorial Campus | |
| Asheville, North Carolina, United States, 28801 | |
| Presbyterian Cancer Center at Presbyterian Hospital | |
| Charlotte, North Carolina, United States, 28233-3549 | |
| Wayne Radiation Oncology | |
| Goldsboro, North Carolina, United States, 27534 | |
| United States, North Dakota | |
| Trinity CancerCare Center | |
| Minot, North Dakota, United States, 58701 | |
| United States, Ohio | |
| Summa Center for Cancer Care at Akron City Hospital | |
| Akron, Ohio, United States, 44309-2090 | |
| McDowell Cancer Center at Akron General Medical Center | |
| Akron, Ohio, United States, 44307 | |
| Radiation Oncology Center | |
| Alliance, Ohio, United States, 44601 | |
| Barberton Citizens Hospital | |
| Barberton, Ohio, United States, 44203 | |
| Mercy Cancer Center at Mercy Medical Center | |
| Canton, Ohio, United States, 44708 | |
| Adena Regional Medical Center | |
| Chillicothe, Ohio, United States, 45601 | |
| CCOP - Columbus | |
| Columbus, Ohio, United States, 43215 | |
| David L. Rike Cancer Center at Miami Valley Hospital | |
| Dayton, Ohio, United States, 45409 | |
| Good Samaritan Hospital | |
| Dayton, Ohio, United States, 45406 | |
| Grandview Hospital | |
| Dayton, Ohio, United States, 45405 | |
| CCOP - Dayton | |
| Dayton, Ohio, United States, 45420 | |
| Samaritan North Cancer Care Center | |
| Dayton, Ohio, United States, 45415 | |
| Middletown Regional Hospital | |
| Franklin, Ohio, United States, 45005-1066 | |
| Charles F. Kettering Memorial Hospital | |
| Kettering, Ohio, United States, 45429 | |
| MedCentral - Mansfield Hospital | |
| Mansfield, Ohio, United States, 44903 | |
| Cancer Care Center, Incorporated | |
| Salem, Ohio, United States, 44460 | |
| UVMC Cancer Care Center at Upper Valley Medical Center | |
| Troy, Ohio, United States, 45373-1300 | |
| Cancer Treatment Center | |
| Wooster, Ohio, United States, 44691 | |
| United States Air Force Medical Center - Wright-Patterson | |
| Wright-Patterson Afb, Ohio, United States, 45433-5529 | |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | |
| Xenia, Ohio, United States, 45385 | |
| United States, Oklahoma | |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | |
| Tulsa, Oklahoma, United States, 74136 | |
| United States, Pennsylvania | |
| Rosenfeld Cancer Center at Abington Memorial Hospital | |
| Abington, Pennsylvania, United States, 19001 | |
| UPMC Cancer Center at Beaver Medical Center | |
| Beaver, Pennsylvania, United States, 15009 | |
| UPMC Cancer Center at Jefferson Regional Medical Center | |
| Clairton, Pennsylvania, United States, 15025 | |
| Northeast Radiation Oncology Center | |
| Dunmore, Pennsylvania, United States, 18512 | |
| UPMC Cancer Center - Arnold Palmer Pavilion | |
| Greensburg, Pennsylvania, United States, 15601 | |
| UPMC Cancer Center at the John P. Murtha Pavilion | |
| Johnstown, Pennsylvania, United States, 15901 | |
| UPMC Cancer Center at UPMC McKeesport | |
| McKeesport, Pennsylvania, United States, 15132 | |
| UPMC - Moon | |
| Moon Township, Pennsylvania, United States, 15108 | |
| UPMC Cancer Center - Natrona Heights | |
| Natrona Heights, Pennsylvania, United States, 15065 | |
| Jameson Memorial Hospital - North Campus | |
| New Castle, Pennsylvania, United States, 16105 | |
| UPMC Cancer Center - Upper St. Clair | |
| Pittsburgh, Pennsylvania, United States, 15243 | |
| UPMC - Shadyside | |
| Pittsburgh, Pennsylvania, United States, 15213-2582 | |
| UPMC Cancer Center at Magee-Womens Hospital | |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| UPMC Cancer Center at UPMC Passavant | |
| Pittsburgh, Pennsylvania, United States, 15237 | |
| UPMC Cancer Center at UPMC St. Margaret | |
| Pittsburgh, Pennsylvania, United States, 15215 | |
| UPMC Cancer Center at UPMC Presbyterian | |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| UPMC Cancer Center at UPMC Northwest | |
| Seneca, Pennsylvania, United States, 16346 | |
| Mount Nittany Medical Center | |
| State College, Pennsylvania, United States, 16803 | |
| UPMC Cancer Center - Uniontown | |
| Uniontown, Pennsylvania, United States, 15401 | |
| Washington Hospital Cancer Center | |
| Washington, Pennsylvania, United States, 15301 | |
| York Cancer Center at Apple Hill Medical Center | |
| York, Pennsylvania, United States, 17405 | |
| United States, South Carolina | |
| Hollings Cancer Center at Medical University of South Carolina | |
| Charleston, South Carolina, United States, 29425 | |
| CCOP - Greenville | |
| Greenville, South Carolina, United States, 29615 | |
| United States, Utah | |
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | |
| Murray, Utah, United States, 84157 | |
| Dixie Regional Medical Center - East Campus | |
| Saint George, Utah, United States, 84770 | |
| LDS Hospital | |
| Salt Lake City, Utah, United States, 84143 | |
| Utah Cancer Specialists at UCS Cancer Center | |
| Salt Lake City, Utah, United States, 84106 | |
| United States, Washington | |
| St. Francis Hospital | |
| Federal Way, Washington, United States, 98003 | |
| Good Samaritan Cancer Center | |
| Puyallup, Washington, United States, 98372 | |
| CCOP - Virginia Mason Research Center | |
| Seattle, Washington, United States, 98101 | |
| Franciscan Cancer Center at St. Joseph Medical Center | |
| Tacoma, Washington, United States, 98405-3004 | |
| MultiCare Regional Cancer Center at Tacoma General Hospital | |
| Tacoma, Washington, United States, 98405 | |
| CCOP - Northwest | |
| Tacoma, Washington, United States, 98405 | |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | |
| Yakima, Washington, United States, 98902 | |
| United States, Wisconsin | |
| Theda Care Cancer Institute | |
| Appleton, Wisconsin, United States, 54911 | |
| Bellin Memorial Hospital | |
| Green Bay, Wisconsin, United States, 54301 | |
| Riverview UW Cancer Center at Riverview Hospital | |
| Wisconsin Rapids, Wisconsin, United States, 54494 | |
| United States, Wyoming | |
| Welch Cancer Center at Sheridan Memorial Hospital | |
| Sheridan, Wyoming, United States, 82801 | |
Sponsors and Collaborators
Radiation Therapy Oncology Group
Investigators
| Study Chair: | Michael J. Seider, MD, PhD, FACR | Summa Center for Cancer Care at Akron City Hospital |
More Information
Additional Information:
No publications provided
| Responsible Party: | Walter John Curran, Jr, Radiation Therapy Oncology Group |
| ClinicalTrials.gov Identifier: | NCT00365105 History of Changes |
| Other Study ID Numbers: | CDR0000491233, RTOG-0517 |
| Study First Received: | August 16, 2006 |
| Last Updated: | June 26, 2012 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
|
pain bone metastases extensive stage small cell lung cancer recurrent breast cancer stage IV breast cancer |
recurrent non-small cell lung cancer stage IV non-small cell lung cancer recurrent prostate cancer stage IV prostate cancer |
Additional relevant MeSH terms:
|
Breast Neoplasms Lung Neoplasms Neoplasm Metastasis Neoplasms Neoplasms, Second Primary Prostatic Neoplasms Neoplasms by Site Breast Diseases Skin Diseases Respiratory Tract Neoplasms Thoracic Neoplasms Lung Diseases Respiratory Tract Diseases Neoplastic Processes Pathologic Processes |
Genital Neoplasms, Male Urogenital Neoplasms Genital Diseases, Male Prostatic Diseases Zoledronic acid Calcium, Dietary Vitamin D Ergocalciferols Diphosphonates Calcium Carbonate Vitamins Samarium ethylenediaminetetramethylenephosphonate Bone Density Conservation Agents Physiological Effects of Drugs Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 22, 2013