Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

This study has been completed.

First Received on July 26, 2006. Last Updated on August 29, 2007 History of Changes

Sponsor:	Danish Headache Center
Information provided by:	Danish Headache Center
ClinicalTrials.gov Identifier:	NCT00357864

Purpose

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Condition	Intervention
Headache	Drug: carbachol

Study Type:	Observational
Study Design:	Additional Descriptors: Convenience Sample Primary Purpose: Screening Time Perspective: Longitudinal Time Perspective: Prospective
Official Title:	Basic Research on Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow in a Humane Experimental Headache Model

Resource links provided by NLM:

MedlinePlus related topics: Headache

Drug Information available for: Carbachol

U.S. FDA Resources

Further study details as provided by Danish Headache Center:

Enrollment:	15
Study Start Date:	July 2006
Study Completion Date:	April 2007

Detailed Description:

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Eligibility

Ages Eligible for Study:	18 Years to 40 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy volunteers
Aged 18-40
50-100 kg
Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

Tension type headache more than once/month
Other primary headaches
Daily medication except contraceptives
Drug taken within 4 times the halflife for the specific drug except contraceptives
Pregnant or lactating women
Exposure to radiation within the last year
Headache within the last 24 hours before start of trial
Hypertension
Hypotension
Respiratory or cardiac disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00357864

Locations

Denmark
Dansih Headache Center
Glostrup, Denmark, 2600

Sponsors and Collaborators

Danish Headache Center

Investigators

Principal Investigator:

henrik schytz

Danish Headache Center

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00357864 History of Changes
Other Study ID Numbers:	2006-002462-19
Study First Received:	July 26, 2006
Last Updated:	August 29, 2007
Health Authority:	Denmark: Danish Medicines Agency

Additional relevant MeSH terms:

Headache
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Carbachol
Cardiotonic Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Miotics
Autonomic Agents

Peripheral Nervous System Agents
Physiological Effects of Drugs
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Central Nervous System Agents
Protective Agents

ClinicalTrials.gov processed this record on February 12, 2012