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Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2012 by National Cancer Institute (NCI)
Sponsor:
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00309985
First received: March 29, 2006
Last updated: December 4, 2012
Last verified: December 2012
  Purpose

RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen ablation therapy may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether androgen-ablation therapy is more effective with or without docetaxel in treating metastatic prostate cancer.

PURPOSE: This randomized phase III trial is studying androgen-ablation therapy and chemotherapy to see how well they work compared to androgen-ablation therapy alone in treating patients with metastatic prostate cancer.


Condition Intervention Phase
Prostate Cancer
Drug: antiandrogen therapy
Drug: docetaxel
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Open Label
Primary Purpose: Treatment
Official Title: CHAARTED: ChemoHormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer [CHAARTED]

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Overall survival [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Prostate-specific antigen (PSA) response [ Designated as safety issue: No ]
  • Change in PSA over time [ Designated as safety issue: No ]
  • Time to hormone refractory disease [ Designated as safety issue: No ]
  • Time to clinical progression [ Designated as safety issue: No ]
  • Time to PSA progression [ Designated as safety issue: No ]
  • Toxicity [ Designated as safety issue: Yes ]

Estimated Enrollment: 780
Study Start Date: July 2006
Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm A
Patients receive androgen-deprivation therapy (including luteinizing hormone-releasing hormone [LHRH] agonist therapy, LHRH antagonist therapy, or surgical castration). Patients also receive docetaxel IV over 1 hour on day 1. Treatment with docetaxel repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Drug: antiandrogen therapy
No information provided
Drug: docetaxel
Given IV
Active Comparator: Arm B
Patients receive androgen-deprivation therapy (as in arm A) alone.
Drug: antiandrogen therapy
No information provided

Detailed Description:

OBJECTIVES:

Primary

  • Evaluate the ability of early chemotherapy to improve overall survival of patients commencing androgen deprivation for metastatic prostate cancer.

Secondary

  • Determine whether early chemotherapy can increase the time to clinical progression (radiographic or symptomatic deterioration due to disease) over hormonal therapy alone.
  • Determine whether early chemotherapy can increase the time to development of hormone-refractory disease over hormonal therapy alone.
  • Determine whether early chemotherapy can increase the time to serological progression over hormonal therapy alone.
  • Determine rates of biochemical response at 6 months and 12 months in the chemohormonal arm versus the hormonal therapy alone arm.
  • Determine the frequency of adverse events and the tolerability of chemotherapy combined with hormonal therapy versus hormonal therapy alone.
  • Determine whether the postulated clinically meaningful increase in disease control is associated with an alteration in overall quality of life using the Functional Assessment of Cancer Therapy-Prostate questionnaire.
  • Determine the ability of prostate-specific antigen changes to be a surrogate for clinical benefit from therapy and overall survival.

Tertiary

  • Determine whether there are proteins differentially translated from the genome in hormone-sensitive prostate cancer, prostate cancer that has responded to hormonal therapy, and hormone-refractory prostate cancer.
  • Determine the frequency of constitutive polymorphisms of enzymes involved in steroid metabolism and other carcinogenic processes.
  • Determine whether the amount and frequency of certain carcinogenic proteins in prostate cancer tissue such as CXCR4 and manganese superoxide dismutase can be correlated with a poor prognosis.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age (≥ 70 vs < 70), ECOG performance status (0-1 vs 2), combined androgen blockade for > 30 days (yes vs no), duration of prior adjuvant hormonal therapy (> 12 months vs ≤ 12 months), concurrent bisphosphonate use (yes vs no), and volume of disease (low vs high). Patients are randomized to 1 of 2 treatment arms.

  • Arm A: Patients receive androgen-deprivation therapy (including luteinizing hormone-releasing hormone [LHRH] agonist therapy, LHRH antagonist therapy, or surgical castration). Patients also receive docetaxel IV over 1 hour on day 1. Treatment with docetaxel repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
  • Arm B: Patients receive androgen-deprivation therapy (as in arm A) alone. Quality of life is assessed at baseline and at weeks 12, 24, 36, and 48.

After completion of study treatment, patients are followed up periodically for up to 10 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed prostate cancer

    • High-volume metastatic disease meeting any of the following criteria:

      • Visceral metastases (extranodal)
      • Bone metastases

        • At least 4 bone lesions
        • At least 1 bone lesion must be outside of the vertebral column or pelvis
  • On androgen-deprivation therapy for < 120 days

    • Prostate-specific antigen (PSA) level may not have risen and met criteria for progression from its lowest point between the start of androgen-deprivation therapy and randomization

PATIENT CHARACTERISTICS:

  • ECOG performance status (PS) 0-2

    • PS 2 eligible only if decline in PS is due to metastatic prostate cancer
  • Absolute neutrophil count ≥ 1,500/mm^3
  • Platelet count ≥ 100,000/mm^3
  • Bilirubin ≤ upper limit of normal (ULN)
  • ALT ≤ 2.5 times ULN
  • Creatinine clearance ≥ 30 mL/min
  • PT and INR ≤ 1.5 times ULN (unless on therapeutic anticoagulation)
  • PTT ≤ 1.5 times ULN (unless on therapeutic anticoagulation)
  • No prior malignancy in the past 5 years except for basal cell or squamous cell carcinoma of the skin

    • Other malignancies that are considered to have low potential to progress (e.g., grade 2, T1a transitional cell carcinoma) may be allowed if approved by study chair
  • No peripheral neuropathy > grade 1
  • No history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80
  • No active cardiac disease, including the following:

    • Active angina
    • Symptomatic congestive heart failure
    • Myocardial infarction within the past 6 months
  • Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • At least 4 weeks since prior major surgery and recovered from all toxicity prior to randomization
  • Prior adjuvant or neoadjuvant hormonal therapy allowed provided the following are true:

    • Therapy was discontinued ≥ 12 months ago AND there is no evidence of disease, as defined by 1 of the following:

      • PSA < 0.1 ng/dL after prostatectomy plus hormonal therapy
      • PSA < 0.5 ng/dL and has not doubled above nadir after radiotherapy plus hormonal therapy
    • Therapy lasted no more than 24 months

      • Last depot injection must have expired by the 24-month mark
  • Prior palliative radiotherapy allowed if commenced within 30 days before starting androgen deprivation
  • Anti-androgen therapy allowed as single-agent therapy ≤ 7 days before medial castration to prevent flare
  • No prior chemotherapy in adjuvant or neoadjuvant setting
  • No prior hormone therapy in the metastatic setting
  • More than 30 days (or 6 half-lives) (whichever is longer) since prior participation in another clinical trial
  • Patients can not simultaneously enroll on CALGB 90202
  • Concurrent participation in nontherapeutic trials allowed
  • Concurrent antiandrogen therapy (e.g., bicalutamide or flutamide) allowed, but not as sole hormonal therapy
  • No concurrent 5-alpha reductase inhibitors
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00309985

  Hide Study Locations
Locations
United States, Alaska
Providence Cancer Center Recruiting
Anchorage, Alaska, United States, 99508
Contact: Clinical Trials Office - Providence Cancer Center    907-261-3109      
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Recruiting
Fairbanks, Alaska, United States, 99701
Contact: John M. Corman, MD    206-223-6177      
United States, Arizona
Mayo Clinic Hospital Recruiting
Phoeniz, Arizona, United States, 85054
Contact: Manish Kohli    480-515-6296      
Mayo Clinic Scottsdale Recruiting
Scottsdale, Arizona, United States, 85259-5499
Contact: Clinical Trials Office - All Mayo Clinic Locations    507-538-7623      
United States, Arkansas
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center Recruiting
Fort Smith, Arkansas, United States, 72903
Contact: John D. Wells, MD    479-484-4700      
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Clinical Trial Office - Arkansas Cancer Research Center at Uni    501-686-8274      
United States, California
Alta Bates Summit Comprehensive Cancer Center Recruiting
Berkeley, California, United States, 94704
Contact: Clinical Trials Office - Alta Bates Summit Comprehensive Cance    510-204-3428      
Peninsula Medical Center Recruiting
Burlingame, California, United States, 94010
Contact: David H. Irwin, MD    510-204-1591      
California Cancer Care, Incorporated - Greenbrae Recruiting
Greenbrae, California, United States, 94904
Contact: Peter D. Eisenberg, MD    415-925-5000      
USC/Norris Comprehensive Cancer Center and Hospital Recruiting
Los Angeles, California, United States, 90089-9181
Contact: Clinical Trials Office - USC/Norris Comprehensive Cancer Cente    323-865-0451      
Tibotec Therapeutics - Division of Ortho Biotech Products, LP Recruiting
Marysville, California, United States, 95901
Contact: Primo N. Lara, MD    916-734-3771      
Mather Veteran Affairs Medical Center Recruiting
Mather, California, United States, 95655
Contact: Chong-Xian Pan    916-843-7000      
Mercy Cancer Center at Mercy Medical Center Recruiting
Merced, California, United States, 95340
Contact: Prasad Pillai    209-386-6015      
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: Clinical Trials Office - Memorial Medical Center    209-572-7116      
Sutter Health - Western Division Cancer Research Group Recruiting
Novato, California, United States, 94945
Contact: David H. Irwin, MD    510-204-1591      
University of California Davis Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Clinical Trials Office - University of California Davis Cancer    916-734-3089      
Saint Helena Hospital Recruiting
Saint Helena, California, United States, 94574
Contact: Gregory B. Smith    707-963-3611      
California Pacific Medical Center - California Campus Recruiting
San Francisco, California, United States, 94118
Contact: David H. Irwin, MD    510-204-1591      
Sutter Pacific Medical Foundation Recruiting
Santa Rosa, California, United States, 95403
Contact: David H. Irwin, MD    510-204-1591      
Tahoe Forest Cancer Center Recruiting
Truckee, California, United States, 96161
Contact: Primo N. Lara, MD    916-734-3771      
Sutter Solano Medical Center Recruiting
Vallejo, California, United States, 94589
Contact: David H. Irwin, MD    510-204-1591      
United States, Colorado
University of Colorado Cancer Center at UC Health Sciences Center Recruiting
Aurora, Colorado, United States, 80045
Contact: Clinical Trials Office - University of Colorado Cancer Center    720-848-0650      
Veterans Affairs Medical Center - Denver Recruiting
Denver, Colorado, United States, 80220
Contact: L. Michael Glode, MD    303-724-3853      
Shaw Regional Cancer Center Recruiting
Edwards, Colorado, United States, 81632
Contact: L. Michael Glode, MD    303-724-3853      
Front Range Cancer Specialists Recruiting
Fort Collins, Colorado, United States, 80528
Contact: Diana C. Medgyesy, MD    970-212-7600      
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Clinical Trials Office - Poudre Valley Hospital    970-495-8226      
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center Recruiting
Grand Junction, Colorado, United States, 81502
Contact: L. Michael Glode, MD    303-724-3853      
Montrose Memorial Hospital Cancer Center Recruiting
Montrose, Colorado, United States, 81401
Contact: Clinical Trials Office - Montrose Memorial Hospital Cancer Cen    670-240-7267      
United States, Connecticut
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Philip J. Stella, MD    734-712-1000      
Yale Cancer Center Recruiting
New Haven, Connecticut, United States, 06520-8028
Contact: Clinical Trials Office - Yale Cancer Center    203-785-5702      
United States, District of Columbia
George Washington University Medical Center Recruiting
Washington, District of Columbia, United States, 20037
Contact: Clinical Trials Office - George Washington University Medical    202-741-2981      
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center Recruiting
Washington, District of Columbia, United States, 20007
Contact: Clinical Trials Office - Lombardi Comprehensive Cancer Center    202-444-0381      
United States, Florida
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Recruiting
Fort Lauderdale, Florida, United States, 33308
Contact: Clinical Trials Office - Michael and Dianne Bienes Comprehensi    954-776-3239      
University of Florida Shands Cancer Center Recruiting
Gainesville, Florida, United States, 32610-0232
Contact: Clinical Trials Office - University of Florida Shands Cancer C    888-254-7581      
Mayo Clinic - Jacksonville Recruiting
Jacksonville, Florida, United States, 32224
Contact: Clinical Trials Office - All Mayo Clinic Locations    507-538-7623      
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Recruiting
Jupiter, Florida, United States, 33458
Contact: Clinical Trials Office - Ella Milbank Foshay Cancer Center    561-745-5768      
CCOP - Mount Sinai Medical Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Michael Schwartz, MD    305-535-3310      
United States, Georgia
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Richard J. LoCicero, MD    770-297-5700      
United States, Idaho
Mountain States Tumor Institute at St. Luke's Regional Medical Center Recruiting
Boise, Idaho, United States, 83712
Contact: Paul G. Montgomery, MD    208-381-2711      
Saint Luke's Mountain States Tumor Institute - Fruitland Recruiting
Fruitland, Idaho, United States, 83619
Contact: Paul G. Montgomery, MD    208-381-2711      
Idaho Urologic Institute, PA Recruiting
Meridian, Idaho, United States, 83642
Contact: Philip J. Stella, MD    734-712-1000      
Mountain States Tumor Institute - Meridian Recruiting
Meridian, Idaho, United States, 83642
Contact: Paul G. Montgomery, MD    208-381-2711      
Saint Luke's Mountain States Tumor Institute Recruiting
Nampa, Idaho, United States, 83686
Contact: Paul G. Montgomery, MD    208-381-2711      
Mountain States Tumor Institute at St. Luke's Recruiting
Twin Falls, Idaho, United States, 83301
Contact: Paul G. Montgomery, MD    208-381-2711      
United States, Illinois
Rush-Copley Cancer Care Center Recruiting
Aurora, Illinois, United States, 60504
Contact: David L. Graham    630-499-2400      
Illinois CancerCare - Bloomington Recruiting
Bloomington%, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    309-662-2102      
Graham Hospital Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    309-647-5240      
Illinois CancerCare - Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    309-647-5240      
Illinois CancerCare - Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    217-357-6877      
Memorial Hospital Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    217-357-3131      
Hematology and Oncology Associates Recruiting
Chicago, Illinois, United States, 60611
Contact: Clinical Trails Office - Hematology and Oncology Associates    312-695-1301      
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Recruiting
Chicago, Illinois, United States, 60611-3013
Contact: Clinical Trials Office - Robert H. Lurie Comprehensive Cancer    312-695-1301    cancer@northwestern.edu   
Decatur Memorial Hospital Cancer Care Institute Recruiting
Decatur, Illinois, United States, 62526
Contact: Clinical Trials Office - Decatur Memorial Hospital Cancer Care    217-876-4750      
Eureka Community Hospital Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    309-467-2371      
Illinois CancerCare - Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    309-467-2371      
Evanston Hospital Recruiting
Evanston, Illinois, United States, 60201-1781
Contact: Clinical Trials Office - Evanston Hospital    847-570-1381      
St. Francis Hospital Recruiting
Evanston, Illinois, United States, 60202
Contact: K. Joseph Philip, MD    773-784-6676      
Galesburg Clinic, PC Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    309-344-1000      
Illinois CancerCare - Cottage Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    309-343-4600      
Illinois CancerCare - Havana Recruiting
Havana, Illinois, United States, 62644
Contact: Nguyet A. Le-Lindqwister    309-543-8557      
Kellogg Cancer Care Center Recruiting
Highland Park, Illinois, United States, 60035
Contact: Gary R. MacVicar    847-480-3800      
Veterans Affairs Medical Center - Hines Recruiting
Hines, Illinois, United States, 60141
Contact: Nirmala Bhoopalam, MD    708-202-2782      
Hinsdale Hematology Oncology Associates Recruiting
Hinsdale, Illinois, United States, 60521
Contact: Elyse C. Schneiderman, MD    630-654-1790      
Joliet Oncology-Hematology Associates, Limited - West Recruiting
Joliet, Illinois, United States, 60435
Contact: Kulumani M. Sivarajan    815-730-3098      
Provena St. Mary's Regional Cancer Center - Kankakee Recruiting
Kankakee, Illinois, United States, 60901
Contact: Gary R. MacVicar    815-937-8780      
Illinois CancerCare - Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    309-852-0598      
La Grange Memorial Hospital Recruiting
La Grange, Illinois, United States, 60525
Contact: Clinical Trials Office - La Grange Memorial Hospital    630-856-7526      
North Shore Oncology and Hematology Associates, Limited - Libertyville Recruiting
Libertyville, Illinois, United States, 60048
Contact: Gary R. MacVicar    847-367-6781      
Illinois CancerCare - Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    309-833-3503      
McDonough District Hospital Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    309-833-4101      
Cardinal Bernardin Cancer Center at Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Clinical Trials Office - Cardinal Bernardin Cancer Center    708-226-4357      
Illinois CancerCare - Monmouth Recruiting
Monmouth, Illinois, United States, 61462
Contact: Nguyet A. Le-Lindqwister    309-734-3141      
Good Samaritan Regional Health Center Recruiting
Mount Vernon, Illinois, United States, 62864
Contact: Bethany G. Sleckman, MD    314-251-7057      
Hematology Oncology Consultants - Naperville Recruiting
Naperville, Illinois, United States, 60540
Contact: Fariborze B. Barhamand, MD    630-369-1501      
Cancer Care and Hematology Specialists of Chicagoland - Niles Recruiting
Niles, Illinois, United States, 60714
Contact: Gary R. MacVicar    847-827-9060      
BroMenn Regional Medical Center Recruiting
Normal, Illinois, United States, 61761
Contact: Nguyet A. Le-Lindqwister    309-454-1400      
Mid-Illinois Hematology-Oncology Associates at Community Cancer Center Recruiting
Normal, Illinois, United States, 61761
Contact: John J. Migas, MD    309-451-2207      
Illinois CancerCare - Community Cancer Center Recruiting
Normal, Illinois, United States, 61761
Contact: Nguyet A. Le-Lindqwister    309-662-2102      
Community Cancer Center Recruiting
Normal, Illinois, United States, 61761
Contact: Nguyet A. Le-Lindqwister    309-451-8500      
Community Hospital of Ottawa Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    815-433-3100      
Oncology Hematology Associates of Central Illinois, PC - Ottawa Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    815-431-9270      
Cancer Treatment Center at Pekin Hospital Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    309-353-0512      
Illinois CancerCare - Pekin Recruiting
Pekin, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    309-353-0214      
CCOP - Illinois Oncology Research Association Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    309-243-3605      
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61636
Contact: Clinical Trials Office - Methodist Medical Center of Illinois    309-243-3000      
Oncology Hematology Associates of Central Illinois, PC - Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    309-243-3000      
Proctor Hospital Recruiting
Peoria, Illinois, United States, 61614
Contact: Nguyet A. Le-Lindqwister    309-691-1000      
Illinois CancerCare - Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    815-780-3185      
Illinois Valley Community Hospital Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    815-223-3000      
Illinois CancerCare - Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    815-875-3010      
Hematology Oncology Associates - Skokie Recruiting
Skokie, Illinois, United States, 60076
Contact: Gary R. MacVicar    847-568-9930      
Illinois CancerCare - Spring Valley Recruiting
Spring Valley, Illinois, United States, 61362
Contact: Nguyet A. Le-Lindqwister    815-664-1487      
Regional Cancer Center at Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: Clinical Trials Office - Regional Cancer Center at Memorial Me    217-788-4233      
CCOP - Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Clinical Trials Office - CCOP - Carle Cancer Center    800-446-5532      
United States, Indiana
Elkhart Clinic, LLC Recruiting
Elkhart, Indiana, United States, 46514-2098
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Elkhart General Hospital Recruiting
Elkhart, Indiana, United States, 46515
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Michiana Hematology-Oncology, PC - Elkhart Recruiting
Elkhart, Indiana, United States, 46514
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Fort Wayne Medical Oncology and Hematology Recruiting
Fort Wayne, Indiana, United States, 46845
Contact: Sreenivasa R. Nattam, MD    260-484-8830      
William N. Wishard Memorial Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Noah M. Hahn    317-639-6671      
Indiana University Melvin and Bren Simon Cancer Center Recruiting
Indianapolis, Indiana, United States, 46202-5289
Contact: Clinical Trials Office - Indiana University Cancer Center    317-274-2552      
Veterans Affairs Medical Center - Indianapolis Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Noah M. Hahn    317-554-0000      
Howard Community Hospital Recruiting
Kokomo, Indiana, United States, 46904
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Center for Cancer Therapy at LaPorte Hospital and Health Services Recruiting
La Porte, Indiana, United States, 46350
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Saint Anthony Memorial Health Centers Recruiting
Michigan City, Indiana, United States, 46360
Contact: David L. Graham    219-879-8511      
Saint Joseph Regional Medical Center Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Michiana Hematology-Oncology, PC - South Bend Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Michiana Hematology Oncology PC - Plymouth Recruiting
Plymouth, Indiana, United States, 46563
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
CCOP - Northern Indiana CR Consortium Recruiting
South Bend, Indiana, United States, 46601
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Clinical Trials Office - Memorial Hospital of South Bend    800-284-7370      
Michiana Hematology Oncology PC - La Porte Recruiting
Westville, Indiana, United States, 46391
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
United States, Iowa
Medical Oncology and Hematology Associates - West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Robert J. Behrens    515-875-9713      
CCOP - Iowa Oncology Research Association Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-244-7586      
John Stoddard Cancer Center at Iowa Lutheran Hospital Recruiting
Des Moines, Iowa, United States, 50316
Contact: Clinical Trials Office - John Stoddard Cancer Center at Iowa L    515-241-8704      
John Stoddard Cancer Center at Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Clinical Trials Office - John Stoddard Cancer Center at Iowa M    515-241-6727      
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    515-282-2921      
Medical Oncology and Hematology Associates at Mercy Cancer Center Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    515-643-8740      
Mercy Cancer Center at Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    515-643-8206      
Veterans Affairs Medical Center - Iowa City Recruiting
Iowa City, Iowa, United States, 52246
Contact: Daniel A. Vaena    319-338-0581      
McCreery Cancer Center at Ottumwa Regional Recruiting
Ottumwa, Iowa, United States, 52501
Contact: Robert J. Behrens    641-684-2946      
Siouxland Hematology-Oncology Associates, LLP Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender, MD, PhD    712-252-0088      
Mercy Medical Center - Sioux City Recruiting
Sioux City, Iowa, United States, 51102
Contact: Donald B. Wender, MD, PhD    712-252-0088      
St. Luke's Regional Medical Center Recruiting
Sioux City, Iowa, United States, 51104
Contact: Donald B. Wender, MD, PhD    712-252-0088      
United States, Kansas
Hays Medical Center Recruiting
Hays, Kansas, United States, 67601
Contact: Peter J. VanVeldhuizen, MD    816-861-4700ext.56775      
Hutchinson Hospital Corporation Recruiting
Hutchinson, Kansas, United States, 67502
Contact: Peter J. VanVeldhuizen, MD    816-861-4700ext.56775      
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160-7357
Contact: Clinical Trials Office - Kansas Masonic Cancer Research Instit    913-588-4709      
Mount Carmel Regional Cancer Center Recruiting
Pittsburg, Kansas, United States, 66762
Contact: Peter J. VanVeldhuizen, MD    816-861-4700ext.56775      
St. Francis Comprehensive Cancer Center Recruiting
Topeka, Kansas, United States, 66606
Contact: Peter J. VanVeldhuizen, MD    816-861-4700ext.56775      
United States, Kentucky
Lucille P. Markey Cancer Center at University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536-0093
Contact: Clinical Trials Office - Markey Cancer Center at University of    859-257-3379      
United States, Louisiana
Mary Bird Perkins Cancer Center - Baton Rouge Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert W. Veith    225-767-0847      
MBCCOP - LSU Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-568-5151      
Medical Center of Louisiana - New Orleans Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Robert W. Veith    504-903-2311      
United States, Maryland
DeCesaris Cancer Institute at Anne Arundel Medical Center Recruiting
Annapolis, Maryland, United States, 21401
Contact: Jason D. Taksey    443-481-5800      
Veterans Affairs Medical Center - Baltimore Recruiting
Baltimore, Maryland, United States, 21201
Contact: Heather D. Mannuel    410-605-7000      
Greenebaum Cancer Center at University of Maryland Medical Center Recruiting
Baltimore, Maryland, United States, 21201
Contact: Clinical Trials Office - Greenebaum Cancer Center at Universit    800-888-8823      
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting
Baltimore, Maryland, United States, 21231-2410
Contact: Clinical Trials Office - Sidney Kimmel Comprehensive Cancer Ce    410-955-8804    jhcccro@jhmi.edu   
St. Agnes Hospital Cancer Center Recruiting
Baltimore, Maryland, United States, 21229
Contact: Carole Miller, MD    410-368-3414      
Greater Baltimore Medical Center Cancer Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: Clinical Trials Office - Greater Baltimore Medical Center Canc    443-849-3706      
United States, Massachusetts
Boston University Cancer Research Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Clinical Trials Office - Boston University Cancer Research Cen    617-638-8265      
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: Christopher Sweeney, MBBS    317-274-3515      
Lahey Clinic Medical Center - Burlington Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Clinical Trials Office - Lahey Clinic Medical Center - Burling    781-744-8027      
Newton-Wellesley Hospital Recruiting
Newton, Massachusetts, United States, 02462
Contact: Christopher Sweeney, MBBS    317-274-3515      
Jordan Hospital Club Cancer Center Recruiting
Plymouth, Massachusetts, United States, 02360
Contact: James M. Koomey    508-746-2000      
Commonwealth Hematology-Oncology, PC - Quincy Recruiting
Quincy, Massachusetts, United States, 02169
Contact: James R. Everett, MD    781-337-9091      
United States, Michigan
CCOP - Michigan Cancer Research Consortium Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Philip J. Stella, MD    734-712-1000      
Saint Joseph Mercy Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella, MD    734-712-1000      
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109-0942
Contact: Clinical Trials Office - University of Michigan Comprehensive    800-865-1125      
Oakwood Cancer Center at Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48123-2500
Contact: Clinical Trials Office - Oakwood Cancer Center at Oakwood Hosp    313-593-8090      
Green Bay Oncology, Limited - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Gerald K. Bayer, MD    920-432-6049      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Genesys Hurley Cancer Institute    810-762-8057      
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Hurley Medical Center    810-762-8057      
Genesys Regional Medical Center Recruiting
Grand Blanc, Michigan, United States, 48439
Contact: Philip J. Stella, MD    734-712-1000      
Van Elslander Cancer Center at St. John Hospital and Medical Center Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Clincial Trials Office - Van Elslander Cancer Center at St. Jo    313-343-3166      
Dickinson County Healthcare System Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Gerald K. Bayer, MD    920-432-6049      
Foote Memorial Hospital Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip J. Stella, MD    734-712-1000      
Borgess Medical Center Recruiting
Kalamazoo, Michigan, United States, 49001
Contact: Raymond S. Lord, MD    269-373-7458      
Bronson Methodist Hospital Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord, MD    269-373-7458      
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007-3731
Contact: Clinical Trials Office - West Michigan Cancer Center    269-373-7458      
Sparrow Regional Cancer Center Recruiting
Lansing, Michigan, United States, 48912-1811
Contact: Clinical Trials Office - Sparrow Regional Cancer Center    517-364-2890      
St. Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip J. Stella, MD    734-712-1000      
St. Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella, MD    734-712-1000      
Mercy Regional Cancer Center at Mercy Hospital Recruiting
Port Huron, Michigan, United States, 48060
Contact: Philip J. Stella, MD    734-712-1000      
Seton Cancer Institute at Saint Mary's - Saginaw Recruiting
Saginaw, Michigan, United States, 48601
Contact: Clinical Trials Office - Seton Cancer Institute - Saginaw    989-776-8411      
Lakeland Regional Cancer Care Center - St. Joseph Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
Lakeside Cancer Specialists, PLLC Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Jose A. Bufill, MD, FACP    574-234-5123      
St. John Macomb Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella, MD    734-712-1000      
United States, Minnesota
MeritCare Bemidji Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen, MD    701-234-2397      
St. Joseph's Medical Center Recruiting
Brainerd, Minnesota, United States, 56401
Contact: Daniel Nikcevich, MD, PhD    218-786-3625      
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn, MD    612-884-6300      
Mercy and Unity Cancer Center at Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn, MD    612-884-6300      
Miller - Dwan Medical Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel Nikcevich, MD, PhD    218-786-3625      
Duluth Clinic Cancer Center - Duluth Recruiting
Duluth, Minnesota, United States, 55805-1983
Contact: Clinical Trials Office - Duluth Clinic Cancer Center - Duluth    218-786-3308      
CCOP - Duluth Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel Nikcevich, MD, PhD    218-786-3625      
Fairview Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Clinical Trials Office - Fairview Southdale Hospital    612-625-3650      
Mercy and Unity Cancer Center at Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Patrick J. Flynn, MD    612-884-6300      
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Patrick J. Flynn, MD    612-884-6300      
HealthEast Cancer Care at St. John's Hospital Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-884-6300      
Minnesota Oncology - Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn, MD    612-884-6300      
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Clinical Trials Office - Virginia Piper Cancer Institute    612-863-5654      
Hennepin County Medical Center - Minneapolis Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Clinical Trials Office - Hennepin County Medical Center - Minn    612-873-5911      
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Patrick J. Flynn, MD    612-884-6300      
Humphrey Cancer Center at North Memorial Outpatient Center Recruiting
Robbinsdale, Minnesota, United States, 55422-2900
Contact: Clinical Trials Office - Humphrey Cancer Center at North Memor    763-520-1893      
Mayo Clinic Cancer Center Recruiting
Rochester, Minnesota, United States, 55905
Contact: Clinical Trials Office - All Mayo Clinic Locations    507-538-7623      
CentraCare Clinic - River Campus Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    320-252-5131      
Coborn Cancer Center Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    320-229-4907      
Park Nicollet Cancer Center Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-884-6300      
CCOP - Metro-Minnesota Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn, MD    612-884-6300      
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn, MD    612-884-6300      
St. Francis Cancer Center at St. Francis Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick J. Flynn, MD    612-884-6300      
Regions Hospital Cancer Care Center Recruiting
St. Paul, Minnesota, United States, 55101
Contact: Clinical Trials Office - Regions Hospital Cancer Care Center    651-254-1517      
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Patrick J. Flynn, MD    612-884-6300      
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick J. Flynn, MD    612-884-6300      
Willmar Cancer Center at Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Patrick J. Flynn, MD    612-884-6300      
Minnesota Oncology - Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Patrick J. Flynn, MD    612-884-6300      
United States, Mississippi
University of Mississippi Cancer Clinic Recruiting
Jackson, Mississippi, United States, 39216
Contact: Robert D. Hamilton    601-984-5590      
Regional Cancer Center at Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson, MD    228-374-6296      
United States, Missouri
Central Care Cancer Center at Carrie J. Babb Cancer Center Recruiting
Bolivar, Missouri, United States, 65613
Contact: Robert L. Carolla    417-326-7200      
Skaggs Cancer Center at Skaggs Regional Medical Center Recruiting
Branson, Missouri, United States, 65616
Contact: Robert L. Carolla    417-348-8032      
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Bethany G. Sleckman, MD    314-251-7057      
Truman Medical Center - Hospital Hill Recruiting
Kansas City, Missouri, United States, 64108
Contact: Peter J. VanVeldhuizen, MD    816-861-4700ext.56775      
Midwest Hematology Oncology Group, Incorporated Recruiting
Saint Louis, Missouri, United States, 63109
Contact: Bethany G. Sleckman, MD    314-251-7057      
David C. Pratt Cancer Center at St. John's Mercy Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Clinical Trials Office - David C. Pratt Cancer Center at St. J    314-251-6770      
CCOP - St. Louis-Cape Girardeau Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Bethany G. Sleckman, MD    314-251-7057      
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Joel Picus, MD    314-362-5737      
CCOP - Cancer Research for the Ozarks Recruiting
Springfield, Missouri, United States, 65802
Contact: Robert L. Carolla    417-269-4520      
Hulston Cancer Center at Cox Medical Center South Recruiting
Springfield, Missouri, United States, 65807
Contact: Robert L. Carolla    417-269-5257      
St. John's Regional Health Center Recruiting
Springfield, Missouri, United States, 65804
Contact: Robert L. Carolla    417-820-2000      
United States, Montana
Billings Clinic - Downtown Recruiting
Billings, Montana, United States, 59107-7000
Contact: Clinical Trials Office - Billings Clinic - Downtown    800-996-2663    research@billingsclinic.org   
St. Vincent Healthcare Cancer Care Services Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello, MD    406-238-6290      
Hematology-Oncology Centers of the Northern Rockies - Billings Recruiting
Billings, Montana, United States, 59102
Contact: Benjamin T. Marchello, MD    406-238-6290      
CCOP - Montana Cancer Consortium Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello, MD    406-238-6290      
Bozeman Deaconess Cancer Center Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello, MD    406-238-6290      
St. James Healthcare Cancer Care Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello, MD    406-238-6290      
Big Sky Oncology Recruiting
Great Falls, Montana, United States, 59405-5309
Contact: Clinical Trial Office - Big Sky Oncology    406-731-8217      
Great Falls Clinic - Main Facility Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello, MD    406-238-6290      
Sletten Cancer Institute at Benefis Healthcare Recruiting
Great Falls, Montana, United States, 59405
Contact: Grant W. Harrer, MD, FACP, CCTI    406-731-8100      
St. Peter's Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello, MD    406-238-6290      
Glacier Oncology, PLLC Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello, MD    406-238-6290      
Kalispell Medical Oncology at KRMC Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello, MD    406-238-6290      
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello, MD    406-238-6290      
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center Recruiting
Missoula, Montana, United States, 59807
Contact: Clinical Trials Office - Montana Cancer Center at St. Patrick    406-329-7029      
Montana Cancer Specialists at Montana Cancer Center Recruiting
Missoula, Montana, United States, 59807-7877
Contact: Clinical Trials Office - Montana Cancer Specialists at Montana    406-238-6962      
United States, Nevada
CCOP - Nevada Cancer Research Foundation Recruiting
Las Vegas, Nevada, United States, 89106
Contact: John A. Ellerton, MD, CM    702-384-0013      
Nevada Cancer Institute Recruiting
Las Vegas, Nevada, United States, 89135
Contact: Clinical Trials Office - Nevada Cancer Institute    702-822-5136      
United States, New Jersey
Veterans Affairs Medical Center - East Orange Recruiting
East Orange, New Jersey, United States, 07018-1095
Contact: Basil S. Kasimis, MD, DSc    973-395-7809      
Hunterdon Regional Cancer Center at Hunterdon Medical Center Recruiting
Flemington, New Jersey, United States, 08822
Contact: Kenneth B. Blankstein, MD    908-788-6100      
Cancer Institute of New Jersey at Hamilton Recruiting
Hamilton, New Jersey, United States, 08690
Contact: Clinical Trials Office - Cancer Institute of New Jersey at Ham    609-631-6946      
Carol G. Simon Cancer Center at Morristown Memorial Hospital Recruiting
Morristown, New Jersey, United States, 07960
Contact: Steven W. Papish, MD    973-538-5210      
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Clinical Trials Office - Cancer Institute of New Jersey    732-235-8675      
Frederick R. and Betty M. Smith Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Jean H. Hoffman-Censits    973-726-4180      
Overlook Hospital Recruiting
Summit, New Jersey, United States, 07901
Contact: Steven W. Papish, MD    973-538-5210      
United States, New York
Kings County Hospital Center Recruiting
Brooklyn, New York, United States, 11203
Contact: Jason P. Gonsky    718-245-3901      
SUNY Downstate Medical Center Recruiting
Brooklyn, New York, United States, 11203
Contact: Jason P. Gonsky    718-270-4293      
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263-0001
Contact: Clinical Trials Office - Roswell Park Cancer Institute    877-275-7724      
Tucker Center for Cancer Care at Orange Regional Medical Center Recruiting
Middletown, New York, United States, 10940-4199
Contact: Clinical Trials Office - Tucker Center for Cancer Care at Oran    845-342-7609      
NYU Cancer Institute at New York University Medical Center Recruiting
New York, New York, United States, 10016
Contact: Anna C. Ferrari, MD    212-731-5389      
SUNY Upstate Medical University Hospital Recruiting
Syracuse, New York, United States, 13210
Contact: Clinical Trials Office - SUNY Upstate Medical University Hospi    315-464-5476      
Dickstein Cancer Treatment Center at White Plains Hospital Center Recruiting
White Plains, New York, United States, 10601
Contact: Clinical Trials Office - Dickstein Cancer Treatment Center    914-681-2290      
United States, North Carolina
Wayne Memorial Hospital, Incorporated Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins, MD    919-580-0000      
Pardee Memorial Hospital Recruiting
Hendersonville, North Carolina, United States, 28791
Contact: James E. Radford, MD    828-692-8045      
Kinston Medical Specialists Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson, MD    252-559-2200ext.201      
United States, North Dakota
Medcenter One Hospital Cancer Care Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Edward J. Wos, DO    701-323-5741      
Mid Dakota Clinic, PC Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Clinical Trials Office - Mid Dakota Clinic, PC    701-530-6950      
St. Alexius Medical Center Cancer Center Recruiting
Bismarck, North Dakota, United States, 58502
Contact: Clinical Trials Office - St. Alexius Medical Center Cancer Cen    701-530-6950      
CCOP - MeritCare Hospital Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen, MD    701-234-2397      
MeritCare Broadway Recruiting
Fargo, North Dakota, United States, 58102
Contact: Preston D. Steen, MD    701-234-2397      
Roger Maris Cancer Center at MeritCare Hospital Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen, MD    701-234-2397      
United States, Ohio
Summa Center for Cancer Care at Akron City Hospital Recruiting
Akron, Ohio, United States, 44309-2090
Contact: Clinical Trials Office - Akron City Hospital    330-375-6101      
Barberton Citizens Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Jennifer E. Payne    330-745-1611      
Cleveland Clinic Beachwood Family Health and Surgery Center Recruiting
Beachwood, Ohio, United States, 44122
Contact: Anjali S. Advani    216-839-3200      
Aultman Cancer Center at Aultman Hospital Recruiting
Canton, Ohio, United States, 44710-1799
Contact: Clinical Trials Office - Aultman Cancer Center at Aultman Hosp    330-363-6891      
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: Clinical Trials Office - Adena Regional Medical Center    877-779-7585      
Case Comprehensive Cancer Center Recruiting
Cleveland, Ohio, United States, 44106-5065
Contact: Clinical Trials Office - Case Comprehensive Cancer Center    800-641-2422      
Cleveland Clinic Cancer Center at Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Clinical Trials Office - Cleveland Clinic Cancer Center at Fai    216-476-9362      
Cleveland Clinic Taussig Cancer Center Recruiting
Cleveland, Ohio, United States, 44195
Contact: Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente    866-223-8100      
MetroHealth Cancer Care Center at MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Bruce J. Averbook, MD, FACS    216-778-4795      
Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Doctors Hospital at Ohio Health Recruiting
Columbus, Ohio, United States, 43228
Contact: Clinical Trials Office - Doctors Hospital at Ohio Health    614-566-3275      
Grant Medical Center Cancer Care Recruiting
Columbus, Ohio, United States, 43215
Contact: Clinical Trials Office - Grant Medical Center Cancer Care    614-566-4475      
Mount Carmel Health - West Hospital Recruiting
Columbus, Ohio, United States, 43222
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
CCOP - Columbus Recruiting
Columbus, Ohio, United States, 43215
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Riverside Methodist Hospital Cancer Care Recruiting
Columbus, Ohio, United States, 43214-3998
Contact: Clinical Trials Office - Riverside Methodist Hospital Cancer C    614-566-4475      
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Cleveland Clinic Cancer Center Recruiting
Independence, Ohio, United States, 44131
Contact: Anjali S. Advani    216-524-7979      
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
St. Rita's Medical Center Recruiting
Lima, Ohio, United States, 45801
Contact: Clinical Trials Office - St. Rita's Medical Center    419-226-9617      
Strecker Cancer Center at Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Hillcrest Cancer Center at Hillcrest Hospital Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Anjali S. Advani    440-312-4500      
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Licking Memorial Cancer Care Program at Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Parma Community General Hospital Recruiting
Parma, Ohio, United States, 44129
Contact: Clinical Trials Office - Parma Community General Hospital    440-743-4747      
Southern Ohio Medical Center Cancer Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
North Coast Cancer Care, Incorporated Recruiting
Sandusky, Ohio, United States, 44870
Contact: Anjali S. Advani    419-626-9090      
Community Hospital of Springfield and Clark County Recruiting
Springfield, Ohio, United States, 45505
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Cleveland Clinic Foundation - Strongsville Recruiting
Strongsville, Ohio, United States, 44136
Contact: Anjali S. Advani    440-878-2500      
Mount Carmel St. Ann's Cancer Center Recruiting
Westerville, Ohio, United States, 43081
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Cleveland Clinic - Wooster Recruiting
Wooster, Ohio, United States, 44691
Contact: Clinical Trials Office - Cleveland Clinic - Wooster    800-862-7798      
Genesis - Good Samaritan Hospital Recruiting
Zanesville, Ohio, United States, 43701
Contact: Clinical Trials Office - Genesis - Good Samaritan Hospital    740-454-5232      
United States, Oklahoma
Oklahoma University Cancer Institute Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Shubham Pant    405-271-6822      
United States, Pennsylvania
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Clinical Trials Office - Bryn Mawr Hospital    610-645-2680      
Geisinger Cancer Institute at Geisinger Health Recruiting
Danville, Pennsylvania, United States, 17822-0001
Contact: Clinical Trials Office - Geisinger Cancer Institute    570-271-5251      
Delaware County Regional Cancer Center at Delaware County Memorial Hospital Recruiting
Drexel Hill, Pennsylvania, United States, 19026
Contact: Michael M. Mikhail    610-284-8182      
Adams Cancer Center Recruiting
Gettysburg, Pennsylvania, United States, 17325
Contact: Amir Tabatabai, MD    717-741-9229      
Cherry Tree Cancer Center Recruiting
Hanover, Pennsylvania, United States, 17331
Contact: Amir Tabatabai, MD    717-741-9229      
Geisinger Hazleton Cancer Center Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Rajiv Panikkar    570-459-2901      
Cancer Center of Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301-1792
Contact: Clinical Trials Office - Cancer Center of Paoli Memorial Hospi    610-648-1637      
Fox Chase Cancer Center - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19111-2497
Contact: Clinical Trials Office - Fox Chase Cancer Center - Philadelphi    215-728-4790      
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19107-5541
Contact: Clinical Trials Office - Kimmel Cancer Center at Thomas Jeffer    215-955-6084      
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center Recruiting
Reading, Pennsylvania, United States, 19612-6052
Contact: Clinical Trials Office - McGlinn Family Regional Cancer Center    610-988-9323      
St. Joseph Medical Center Recruiting
Reading, Pennsylvania, United States, 19605
Contact: Marc Rovito, MD    610-622-3818      
Geisinger Medical Group - Scenery Park Recruiting
State College, Pennsylvania, United States, 16801
Contact: Rajiv Panikkar    814-231-4560      
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Clinical Trials Office - Frank M. and Dorothea Henry Cancer Ce    570-271-5251      
CCOP - Main Line Health Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Eric L. Raefsky    610-645-2649      
Lankenau Cancer Center at Lankenau Hospital Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Eric L. Raefsky    610-645-2000      
York Cancer Center at Apple Hill Medical Center Recruiting
York, Pennsylvania, United States, 17405
Contact: Amir Tabatabai, MD    717-741-9229      
United States, South Dakota
Avera Cancer Institute Recruiting
Sioux Falls, South Dakota, United States, 57105
Contact: Addison R. Tolentino    605-322-3000      
United States, Tennessee
MBCCOP - Meharry Medical College - Nashville Recruiting
Nashville, Tennessee, United States, 37208-3599
Contact: Steven N. Wolff, MD    615-327-6277      
United States, Texas
Veterans Affairs Medical Center - San Antonio (Murphy) Recruiting
San Antonio, Texas, United States, 78209
Contact: Anand B. Karnad, MD    210-567-4777      
University Hospital - San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Anand B. Karnad, MD    210-567-4777      
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229-3900
Contact: Anand B. Karnad, MD    210-567-4777      
Cancer Therapy and Research Center Recruiting
San Antonio, Texas, United States, 78229
Contact: Clinical Trials Office - Cancer Therapy and Research Center    210-616-5798      
United States, Virginia
University of Virginia Cancer Center Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Geoffrey R. Weiss, MD    434-243-0066      
Lynchburg Hematology-Oncology Clinic Recruiting
Lynchburg, Virginia, United States, 24501
Contact: John Leach MacNeill, MD    434-947-5925      
United States, Washington
Cascade Cancer Center at Evergreen Hospital Medical Center Recruiting
Kirkland, Washington, United States, 98033
Contact: John M. Corman, MD    206-223-6177      
CCOP - Virginia Mason Research Center Recruiting
Seattle, Washington, United States, 98101
Contact: John M. Corman, MD    206-223-6177      
Pacific Medical Center Recruiting
Seattle, Washington, United States, 98104
Contact: John M. Corman, MD    206-223-6177      
Virginia Mason Medical Center Recruiting
Seattle, Washington, United States, 98101
Contact: John M. Corman, MD    206-223-6177      
United States, West Virginia
West Virginia University Health Sciences Center - Charleston Recruiting
Charleston, West Virginia, United States, 25304
Contact: Steven J. Jubelirer, MD    304-388-8380      
United States, Wisconsin
Langlade Memorial Hospital Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Hamied R. Rezazadeh, MD    715-847-2121      
Marshfield Clinic - Chippewa Center Recruiting
Chippewa Falls, Wisconsin, United States, 54729
Contact: Seth O. Fagbemi, MD    715-387-5426      
Marshfield Clinic Cancer Care at Regional Cancer Center Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Seth O. Fagbemi, MD    715-387-5426      
Green Bay Oncology, Limited at St. Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Gerald K. Bayer, MD    920-432-6049      
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: Clinical Trials Office - Vince Lombardi Cancer Clinic - Green    414-649-5717      
St. Mary's Hospital Medical Center - Green Bay Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Gerald K. Bayer, MD    920-432-6049      
St. Vincent Hospital Regional Cancer Center Recruiting
Green Bay, Wisconsin, United States, 54307-3508
Contact: Clinical Trials Office - St. Vincent Hospital Regional Cancer    920-433-8889      
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Gerald K. Bayer, MD    920-432-6049      
UW Cancer Center Johnson Creek Recruiting
Johnson Creek, Wisconsin, United States, 53038
Contact: Glenn Liu, MD    608-265-8689      
Gundersen Lutheran Center for Cancer and Blood Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Clinical Trials Office - Gundersen Lutheran Cancer Center    608-775-2385    cancerctr@gundluth.org   
Dean Medical Center - Madison Recruiting
Madison, Wisconsin, United States, 53717
Contact: Amit Sanyal    608-252-8000      
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Recruiting
Madison, Wisconsin, United States, 53792-6164
Contact: Clinical Trials Office - University of Wisconsin Paul P. Carbo    608-262-5223      
Holy Family Memorial Medical Center Cancer Care Center Recruiting
Manitowoc, Wisconsin, United States, 54221-1450
Contact: Clinical Trials Office - Holy Family Memorial Medical Center C    920-320-2749      
Bay Area Cancer Care Center at Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Gerald K. Bayer, MD    920-432-6049      
Vince Lombardi Cancer Clinic - Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Dhimant R. Patel, MD    920-288-4180      
Marshfield Clinic - Marshfield Center Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Clinical Trials Office - Marshfield Clinic - Marshfield Center    800-782-1581 ext. 94457      
Saint Joseph's Hospital Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Seth O. Fagbemi, MD    715-387-5426      
Medical College of Wisconsin Cancer Center Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Clinical Trials Office - Medical College of Wisconsin Cancer C    414-805-4380      
Marshfield Clinic - Lakeland Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Seth O. Fagbemi, MD    715-387-5426      
Green Bay Oncology, Limited - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Gerald K. Bayer, MD    920-432-6049      
Ministry Medical Group at Saint Mary's Hospital Recruiting
Rhinelander, Wisconsin, United States, 54501
Contact: Seth O. Fagbemi, MD    715-387-5426      
Marshfield Clinic - Indianhead Center Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Seth O. Fagbemi, MD    715-387-5426      
St. Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Gerald K. Bayer, MD    920-432-6049      
Vince Lombardi Cancer Clinic - Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Clinical Trials Office - Vince Lombardi Cancer Clinic - Sheboy    414-649-7200      
Saint Michael's Hospital Cancer Center Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Seth O. Fagbemi, MD    715-387-5426      
Marshfield Clinic at Saint Michael's Hospital Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Seth O. Fagbemi, MD    715-387-5426      
Green Bay Oncology, Limited - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Gerald K. Bayer, MD    920-432-6049      
Aurora Medical Center Recruiting
Summit, Wisconsin, United States, 53066
Contact: Dhimant R. Patel, MD    920-288-4180      
Vince Lombardi Cancer Clinic - Two Rivers Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Dhimant R. Patel, MD    920-288-4180      
Marshfield Clinic - Wausau Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Seth O. Fagbemi, MD    715-387-5426      
University of Wisconcin Cancer Center at Aspirus Wausau Hospital Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Clinical Trials Office - University of Wisconsin Cancer Center    608-262-5223      
Oncology Alliance, SC - Milwaukee - West Recruiting
Wauwatosa, Wisconsin, United States, 53226
Contact: Rubina Qamar    414-476-8450      
Diagnostic and Treatment Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Seth O. Fagbemi, MD    715-387-5426      
Marshfield Clinic - Weston Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Seth O. Fagbemi, MD    715-387-5426      
Marshfield Clinic - Wisconsin Rapids Center Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Seth O. Fagbemi, MD    715-387-5426      
United States, Wyoming
Rocky Mountain Oncology Recruiting
Casper, Wyoming, United States, 82609
Contact: Benjamin T. Marchello, MD    406-238-6290      
Sponsors and Collaborators
Eastern Cooperative Oncology Group
Investigators
Study Chair: Christopher Sweeney, MBBS Royal Adelaide Hospital Cancer Centre
Investigator: David Jarrard, MD University of Wisconsin, Madison
  More Information

Additional Information:
No publications provided

Responsible Party: Robert L. Comis, ECOG Group Chair's Office
ClinicalTrials.gov Identifier: NCT00309985     History of Changes
Other Study ID Numbers: CDR0000462099, ECOG-E3805
Study First Received: March 29, 2006
Last Updated: December 4, 2012
Health Authority: Unspecified

Keywords provided by National Cancer Institute (NCI):
recurrent prostate cancer
stage IV prostate cancer

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Diseases, Male
Genital Neoplasms, Male
Neoplasms
Neoplasms by Site
Prostatic Diseases
Urogenital Neoplasms
Androgen Antagonists
Androgens
Docetaxel
Antimitotic Agents
Antineoplastic Agents
Hormone Antagonists
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
Tubulin Modulators

ClinicalTrials.gov processed this record on November 27, 2014