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| Sponsor: | Boehringer Ingelheim Pharmaceuticals |
|---|---|
| Information provided by: | Boehringer Ingelheim Pharmaceuticals |
| ClinicalTrials.gov Identifier: | NCT00274638 |
Purpose
To demonstrate that Telmisartan combined with Hydrochlorothiazide (MICARDIS® HCT) is superior to Losartan with Hydrochlorothiazide (Hyzaar®) in lowering blood pressure in mild-moderate hypertensives.
| Condition | Intervention | Phase |
|---|---|---|
|
Hypertension |
Drug: Telmisartan & Hydrochlorothiazide Drug: Losartan & Hydrochlorothiazide Procedure: ABPM |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | PROBE Parallel Group 6 wk Treatment Comparing Telmisartan + HCT (40/12.5mg, or 80/12.5mg) With Losartan + HCT (50/12.5mg) Using ABPM in Pts With Mild-to Moderate Hypertension |
| Estimated Enrollment: | 810 |
| Study Start Date: | July 2002 |
| Primary Completion Date: | July 2003 (Final data collection date for primary outcome measure) |
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Pre-menopausal women (last menstruation <= 1 year prior to signing informed consent) who
Contacts and Locations
Show 69 Study Locations| Study Chair: | Boehringer Ingelheim Study Coordinator | Boehringer Ingelheim Pharmaceuticals |
More Information
| ClinicalTrials.gov Identifier: | NCT00274638 History of Changes |
| Other Study ID Numbers: | 502.387 |
| Study First Received: | January 10, 2006 |
| Last Updated: | May 18, 2012 |
| Health Authority: | United States: Food and Drug Administration |
|
Hypertension Vascular Diseases Cardiovascular Diseases Hydrochlorothiazide Losartan Telmisartan Diuretics Natriuretic Agents Physiological Effects of Drugs Pharmacologic Actions Sodium Chloride Symporter Inhibitors |
Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Antihypertensive Agents Cardiovascular Agents Therapeutic Uses Anti-Arrhythmia Agents Angiotensin II Type 1 Receptor Blockers Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Protease Inhibitors Enzyme Inhibitors |