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Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging
The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2008 by National Institutes of Health Clinical Center (CC).   Recruitment status was  Active, not recruiting

First Received on November 8, 2005.   Last Updated on April 21, 2010   History of Changes
Sponsor: National Institute on Aging (NIA)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00251615
  Purpose

The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.


Condition
Atherosclerosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

Resource links provided by NLM:

MedlinePlus related topics: Atherosclerosis Calcium
U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Biospecimen Retention:   Samples With DNA

Vascular tissue obtained from the surgical site that would have otherwise been discarded and Blood Serum


Estimated Enrollment: 500
Study Start Date: February 2003
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Detailed Description:

The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments.

Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients scheduled for vascular surgery

Criteria

Inclusion Criteria:

  • Ages 21 and older
  • Scheduled for vascular surgery

Exclusion Criteria:

  • Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
  • Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
  • Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney [DPA]) for the volunteer, with the volunteer's assent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00251615

Locations
United States, Maryland
National Institute on Aging, Harbor Hospital
Baltimore, Maryland, United States, 21225
Sponsors and Collaborators
National Institute on Aging (NIA)
Investigators
Principal Investigator: Samer Najjar, MD National Institute on Aging (NIA)
  More Information

Publications:
Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 2004 Nov 5;279(45):46367-72. Epub 2004 Aug 31.
Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem. 2005 Apr 1;280(13):12474-85. Epub 2005 Jan 25.
Abernethy DR, Soldatov NM. Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets. J Pharmacol Exp Ther. 2002 Mar;300(3):724-8. Review.

Responsible Party: Samer Najjar, MD, National Institute of Aging
ClinicalTrials.gov Identifier: NCT00251615     History of Changes
Other Study ID Numbers: AG0058
Study First Received: November 8, 2005
Last Updated: April 21, 2010
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
vascular surgery
vascular aging
arterial aging
surgical tissue
Aging

Additional relevant MeSH terms:
Atherosclerosis
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on February 12, 2012



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