Exercise-training Before Coronary Artery Bypass Graft (CABG)

This study is currently recruiting participants.

Verified September 2011 by Norwegian University of Science and Technology

First Received on September 20, 2005. Last Updated on September 1, 2011 History of Changes

Sponsor:	Norwegian University of Science and Technology
Information provided by (Responsible Party):	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00218985

Purpose

The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Condition	Intervention	Phase
Angina Coronary Artery Disease	Behavioral: Exercise training	Phase I

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Investigator) Primary Purpose: Basic Science
Official Title:	Exercise-training Before Coronary Artery Bypass Graft (CABG)

Resource links provided by NLM:

MedlinePlus related topics: Coronary Artery Bypass Surgery Coronary Artery Disease Exercise and Physical Fitness

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:

Cardiovascular function and quality of life [ Time Frame: Before and after intervention ] [ Designated as safety issue: Yes ]
Cardiomyocyte structure and function [ Time Frame: After the study period ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

Structure and function of cardiomyocytes [ Time Frame: After the intervention period ] [ Designated as safety issue: Yes ]

Estimated Enrollment:	40
Study Start Date:	January 2005
Estimated Study Completion Date:	December 2011
Estimated Primary Completion Date:	December 2011 (Final data collection date for primary outcome measure)

Intervention Details:

Intensity controlled exercise training before the scheduled bypass surgery - or a control group following their physicians advice in regard to physical activity.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Scheduled for CABG both with and without heart failure

Exclusion Criteria:

Unstable angina
Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
Participation in another study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00218985

Contacts

Contact: Ulrik Wisloff, Ph.D	+4773598621	ulrik.wisloff@ntnu.no
Contact: Øyvind Ellingsen, Ph.D, MD		oyvind.ellingsen@ntnu.no

Locations

Norway
Norwegian University of Science and Technology	Recruiting
Trondheim, Norway, 7489
Contact: Ulrik Wisloff, Ph.D ulrik.wisloff@ntnu.no
Principal Investigator: Ulrik Wisloff, Ph.D

Sponsors and Collaborators

Norwegian University of Science and Technology

Investigators

Principal Investigator:

Ulrik Wisloff, Ph.D

Norwegian University of Science and Technology

More Information

No publications provided

Responsible Party:	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00218985 History of Changes
Other Study ID Numbers:	TRIM 158-04
Study First Received:	September 20, 2005
Last Updated:	September 1, 2011
Health Authority:	Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:

Aerobic capacity
Exercise training
CABG
Endothelial function

Additional relevant MeSH terms:

Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases

Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on February 09, 2012