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Disease Modifying Genes in Severe Asthma

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
New York University School of Medicine
ClinicalTrials.gov Identifier:
NCT00212537
First received: September 19, 2005
Last updated: April 18, 2013
Last verified: April 2013
History of Changes
  Purpose

Gene and protein bank to study disease modifying and susceptibility genes and proteins in urban patients with asthma.


Condition
Asthma

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Disease Modifying Genes in Severe Asthma

Resource links provided by NLM:

MedlinePlus related topics: Asthma
U.S. FDA Resources

Further study details as provided by New York University School of Medicine:

Primary Outcome Measures:
  • To recruit and characterize a cohort of subjects with asthma who reside in a high pollution, high asthma risk neighborhood [ Time Frame: five yeARS ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples With DNA

The total amount of blood drawn is approximately 5 tablespoons (75 ml). The blood sample will be processed to isolate "genetic material" (mainly DNA, RNA and protein). This genetic material will be used to try to identify the "genetic factors" or genes that a person inherits that make him or her more likely to develop asthma. The blood is used to test for allergies to weeds, trees, insects and molds (RAST) and a complete blood count.


Estimated Enrollment: 2000
Study Start Date: April 2002
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

All individuals approached for participation in the Research Registry shall be able to read or comprehend English. Since participation in the Research Registry does not involve a risk of physical harm, women of childbearing potential will not be queried as to pregnancy status or tested for pregnancy unless they are requested to undergo a methacholine challenge test. There are no additional inclusion/exclusion criteria.

Criteria

Inclusion Criteria:

  • Ages 18 and above

Exclusion Criteria:

  • Greater than 10 pack year tobacco history
  • Lung diseases other than asthma
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00212537

Locations
United States, New York
NYU School of Medicine
New York, New York, United States, 10016
Sponsors and Collaborators
New York University School of Medicine
Investigators
Principal Investigator: Joan Reibman, MD NYU School of Medicine
  More Information

No publications provided by New York University School of Medicine

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: New York University School of Medicine
ClinicalTrials.gov Identifier: NCT00212537     History of Changes
Other Study ID Numbers: H9698
Study First Received: September 19, 2005
Last Updated: April 18, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by New York University School of Medicine:
Asthma and normal

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
 Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on May 23, 2013