Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections
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Purpose
The aim of this study is to compare the efficacy and impact on growth of two drug treatments against intestinal worms in schoolchildren from a rural area of Guatemala. According to the World Bank, these intestinal worms are one of the top causes of childhood health problems in many areas of the developing world (The World Bank, 1993). Infected children are more likely to have inadequate nutrition due to the worm infections and are more likely to be shorter in height and weigh less than children who are not infected. After collecting height and weight information, we will split the children into two groups. One group will receive albendazole and the other group will receive combined albendazole/ivermectin. Both groups will be receiving albendazole, the current standard of care treatment. Ivermection is expected to improve efficacy and nutritional benefit as well as add increased scope of treatment for the worm Strongyloides, and ectoparasites such as scabies and head lice. Both treatment regimens and the combination have been used millions of times in the developing world and are safe to use. Co-administration of drugs would be a more efficient use of the opportunity to access schoolchildren and provide deworming treatment.
| Condition | Intervention |
|---|---|
|
Ascariasis Trichuriasis Hookworm Infection Strongyloidiasis Pediculosis |
Drug: albendazole vs. combined albendazole/ivermectin treatment |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Treatment |
| Official Title: | Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren |
- efficacy against geohelminths (stool egg count)
- height increase
- weight increase
- ectoparasite examination
| Estimated Enrollment: | 550 |
| Study Start Date: | February 2005 |
| Estimated Study Completion Date: | March 2005 |
The aim of this study is to compare the efficacy and nutritional impact of two drug treatments against intestinal helminths from a rural area of Guatemala. The helminths that will be analyzed in this study are Ascaris lumbricoides, Trichuris trichiura, and hookworm. Because of the manifestations of these helminths infections, nutritional status can deteriorate in infected persons. According to the World Bank, these helminths are one of the top causes of childhood morbidity in many areas of the developing world (The World Bank, 1993).
This information will be gathered by collecting stool samples from schoolchildren, in order to determine the prevalence of infection in children living around Poptun, Guatemala. Height and weight measurements will also be taken, along with a visual exam of the skin for other parasitic skin infections. Children with an inadequate nutritional status are likely to be shorter in height and weigh less than children reared in an area with a low prevalence of helminths. After collecting this baseline information, we will split the children into two groups. One group will receive albendazole and the other group will receive albendazole/ivermectin. Both groups will be receiving is albendazole, the current standard of care treatment. Ivermectin is expected to improve efficacy and nutritional benefit as well as adding increased scope of treatment (Strongyloides, ectoparasites such as scabies and head lice). Both treatment regimens and the combination have been used millions of times in the developing world and are safe to use. Co-administration of drugs is thought to be a more efficient use of the opportunity to access schoolchildren and provide health improvements. Providing data to support expanded treatment options will provide public health officials with the data needed to make such decisions.
Eligibility| Ages Eligible for Study: | 5 Years to 12 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Children will be eligible to participate in the study if they are between 5 and 12 years of age, are students in schools selected for study, and if parental consent and child assent for participation has been obtained.
Exclusion Criteria:
those not fitting criteria above
Contacts and Locations| Guatemala | |
| Various elementary schools | |
| Poptun, Peten, Guatemala | |
| Principal Investigator: | Michael J Beach, Ph.D. | Centers for Disease Control and Prevention |
| Principal Investigator: | Byron Arana, MD | MERTU/CDC-Universite de Valle de Guatemala |
More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00207753 History of Changes |
| Other Study ID Numbers: | CDC-NCID-4283 |
| Study First Received: | September 13, 2005 |
| Last Updated: | November 16, 2005 |
| Health Authority: | United States: Federal Government |
Keywords provided by Centers for Disease Control and Prevention:
|
ascaris trichuris strongyloides hookworm head lice |
Additional relevant MeSH terms:
|
Hookworm Infections Ascariasis Ascaridiasis Ancylostomiasis Lice Infestations Strongyloidiasis Trichuriasis Strongylida Infections Secernentea Infections Nematode Infections Helminthiasis Parasitic Diseases Ascaridida Infections Ectoparasitic Infestations Skin Diseases, Parasitic |
Skin Diseases, Infectious Skin Diseases Rhabditida Infections Enoplida Infections Adenophorea Infections Albendazole Ivermectin Anticestodal Agents Antiplatyhelmintic Agents Anthelmintics Antiparasitic Agents Anti-Infective Agents Therapeutic Uses Pharmacologic Actions Antiprotozoal Agents |
ClinicalTrials.gov processed this record on May 23, 2013