Genetics of Aging-Associated Conditions in Sardinia

This study is currently recruiting participants.

Verified October 2010 by National Institutes of Health Clinical Center (CC)

First Received on September 13, 2005. Last Updated on October 15, 2010 History of Changes

Sponsor:	National Institute on Aging (NIA)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00182949

Purpose

The purpose of this study is to examine the genetic risk factors for aging associated conditions.

Condition
Aging Cardiovascular Disease

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Genetics and Epidemiology of Aging-Associated Traits in the Sardinian Population (SardiNIA)

Resource links provided by NLM:

Genetics Home Reference related topics: Help Me Understand Genetics

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Biospecimen Retention: Samples With DNA

White cells and blood samples

Estimated Enrollment:	6000
Study Start Date:	June 2001
Estimated Study Completion Date:	June 2016
Estimated Primary Completion Date:	June 2016 (Final data collection date for primary outcome measure)

Groups/Cohorts
1 Cohort comprises over 6,200 participants, aged 18-102, from a cluster of 4 towns in Sardinia

Detailed Description:

To simplify the genetic study of risk factors for aging-associated conditions, the Sardinian "founder population" is being used, which has developed to a large modern population over thousands of years without appreciable admixture from without, so that the genetic heterogeneity is relatively reduced. A cohort of 6,000 participants has been enrolled from a cluster of 4 towns. Family history, epidemiological data, and measures of 98 quantitative traits, including cardiovascular risk factors and facets of personality, have been collected. The study is now continuing with longitudinal studies, including second and third visits to repeat measures and add more traits. Full genome scans are being done with the goal of localizing and ultimately identifying genetic variants that account for 5% or more of the variance for each trait.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Residents of any of the 4 towns: Lanusei, Ilbono, Arzana and Ilini, in a valley in the providence of Ogliastra, Sardinia

Criteria

Inclusion Criteria:

Aged 18 and older
From the region of Ogliastra, Sardinia

Exclusion Criteria:

Under 18 years of age

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00182949

Contacts

Contact: National Institute on Aging Protocol Officer	410-350-3947
Contact: Participant Recruitment	011 (39) 0782480078 (Italy)

Locations

Italy
Istituto di Neurogenetica e Neurofarmacologia/Italian National Research (CNR) Lanusei	Recruiting
Ogliastra, Sardinia, Italy
Contact: Participant Recruitment 011 (39) 0782480078
Principal Investigator: Manuela Uda, MD

Sponsors and Collaborators

National Institute on Aging (NIA)

Investigators

Principal Investigator:

David Schlessinger, PhD

National Institute on Aging, Laboratory of Genetics

More Information

No publications provided

Responsible Party:	David Schlessinger, Ph.D., National Institute on Aging
ClinicalTrials.gov Identifier:	NCT00182949 History of Changes
Other Study ID Numbers:	AG0041
Study First Received:	September 13, 2005
Last Updated:	October 15, 2010
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

genetics
DNA

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on February 12, 2012