Comparison of Coronary CT Angiography to Invasive Coronary Angiography

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2005 by Hadassah Medical Organization.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00146887
First received: September 4, 2005
Last updated: November 6, 2006
Last verified: August 2005
  Purpose

The purpose of the trial is to investigate the accuracy of coronary CT compared to the conventional "gold standard" cardiac catheterization.


Condition Intervention
Atherosclerosis, Coronary
Procedure: coronary catheterization

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: A Trial Comparing the Sensitivity and Specificity of Coronary Angiography With Coronary CT Angiography

Resource links provided by NLM:


Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • CT sensitivity and specificity

Estimated Enrollment: 40
Study Start Date: January 2005
Estimated Study Completion Date: August 2005
  Hide Detailed Description

Detailed Description:

40 Patients who are scheduled to undergo coronary angiogram will be recruited at Mount Scopus and Ein Kerem. Patients will be excluded if they have one or more of the following conditions

  1. CABG or stent implantation in the past.
  2. Atrial fibrillation
  3. Contraindication for beta blockers

    1. Obstructive pulmonary disease
    2. Severe peripheral vascular disease
    3. Sick sinus syndrome or AV block greater than 1st degree.
    4. Systolic blood pressure below 100 mm Hg.
  4. Renal disease or other conditions that might increase the risk of contrast nephropathy (diabetes mellitus, SLE, paraproteinemia, malignancy, liver disease)
  5. Allergy to contrast material.

Coronary CT angiography: Patient preparation and data acquisition Pre-procedure preparation: Following informed consent, patients will be scheduled to undergo coronary CT angiography within 7 days prior to coronary angiogram. Patients with heart rates above 75 BPM's will be given 25 mg of metoprolol P.O. 60-90 minutes before the test. If the patient does not reach heart rate below 75, administration of additional IV metoprolol may be considered by a cardiologist.

Scanning protocol: Images will be obtained using collimation of 16x0.75 mm, slice thickness 1 mm reconstructed at increments of 0.5 mm, rotation time 0.42 seconds, kVp 140 and mAs 400. Prior to scanning, 120-150cc of non-ionic contrast material will be injected to a peripheral vein at a rate of 4-5mm/sec. Images will be obtained with ECG gating.

Post processing: The Cardiac CT Angiography software (Philips, Cleveland, USA) allows extraction of the coronary tree from the heart and analysis of the arterial lumen. This application operates on the volume rendered image of the heart. After isolation of the coronary tree, the software enables the selection of an artery for quantitative analysis of its lumen. The obtained information includes presentation of the artery in panoramic views, visualization of the artery and adjacent vascular anatomy in Maximum Intensity Projection (MIP) mode for anatomical enhancement, and cross sectional views, perpendicular to the artery axis for free lumen/diameter analysis, thus providing a tool to estimate stenosis severity and dimensions. Using color mapping, plaque composition is delineated to distinguish calcified from soft plaque.

The Cardiac Review software (Philips, Cleveland, USA) provides detailed views of the patient's cardiac cycle and, using Cine function, allows dynamic viewing of the heart. Using the scanning protocol specified above, cardiac image raw data and an ECG signal are recorded simultaneously. The images are then reconstructed retrospectively in phases. Phases are defined according to the percentage of cardiac contraction, and a series of images is named according to the phase during which they are acquired. The heart can be viewed in any desired cut plane, using the Multi-Planar Formatting (MPR) application.

The Cardiac Review software provides 2 modes of viewing the heart images (Multi Views):

  • Equal phase mode (multi-position), which allows viewing of a number of different cuts of the heart, all at the same cardiac phase
  • Equal position mode (multi-phase), which allows viewing of the same cuts of the heart in different phases The Cardiac Axes Positioning feature provides an easy way to orient the heart to common cardiac views, including short axis, vertical long axis and horizontal axis.

The Cine feature allows viewing the heart in motion. MPR allows scrolling through various portions of the heart while viewing in the cine mode. The sequence can be saved as an AVI format movie.

Angiography: Within 7 days following coronary CT angiography patients will undergo cardiac catheterization with at least the following views: anterior-posterior (AP), right anterior oblique (RAO) cranial, RAO caudal, left anterior oblique (LAO) cranial, and LAO caudal. Additional views (e.g. AP caudal and AP cranial) are at the operator's discretion.

During the hospitalization all patients will undergo echocardiography to assess wall motion abnormalities.

Image interpretation The data will be analyzed in using the following strategies

  1. Basic individual transverse sections
  2. Maximal intensity projections with at least 3 of the following views that are compatible with angiogram: RAO, LAO and spider
  3. Multiplanar reformation.
  4. Three dimensional (3D) displays.

The coronary tree will be divided into the following segments which correlate to conventional angiogram segments Proximal RCA, 2-mid RCA, 3-distal RCA and PL, 4-PDA, 5-LM, 6-proximal LAD, 7-mid LAD, 8-distal LAD, 9-largest diagonal, 10, proximal CX, 11-Distal CX, 12-largest marginal.

These segments will be evaluated by a consensus reading of a cardiologist and a radiologist for the following parameters: existence of atherosclerosis, existence of calcification, percent narrowing within the following ranges <50%, 50%-70%, 70%-90%, tight. These scorings will be used later for comparison with the angiogram results. The physicians interpreting the CT results will be blinded to the results of the angiogram.

For analysis of myocardial function, an axial image series at the mid ventricular level showing papillary muscles through the entire cardiac cycle will be performed to visually identify the maximal systolic constriction phase and diastolic phase as the images showing the largest and smallest left ventricular cavity area, respectively. The corresponding delay in milliseconds from the R peak of the ECG will be used for image reconstruction. Then, a short and a ling axis reconstructed views will be performed to be analyzed at diastole and systole using Simson's disk method to calculate cardiac function.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

40 Patients who are scheduled to undergo coronary angiogram will be recruited at Mount Scopus and Ein Kerem

Exclusion Criteria:

  1. CABG or stent implantation in the past.
  2. Atrial fibrillation
  3. Contraindication for beta blockers

    1. Obstructive pulmonary disease
    2. Severe peripheral vascular disease
    3. Sick sinus syndrome or AV block greater than 1st degree.
    4. Systolic blood pressure below 100 mm Hg.
  4. Renal disease or other conditions that might increase the risk of contrast nephropathy (diabetes mellitus, SLE, paraproteinemia, malignancy, liver disease)
  5. Allergy to contrast material.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00146887

Contacts
Contact: Ronen Durst, MD 972-2-6777111 durst@cc.huji.ac.il

Locations
Israel
Hadassah Medical Center Recruiting
Jerusalem, Israel
Contact: Ronen Durst, MD    972-2-50-7874548    durst@cc.huji.ac.il   
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Principal Investigator: ronen durst, MD Hadassah Medical Organization
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00146887     History of Changes
Other Study ID Numbers: 21-03.09.04-HMO-CTIL, Non applicable
Study First Received: September 4, 2005
Last Updated: November 6, 2006
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:
Coronary CT
sensitivity
specificity

Additional relevant MeSH terms:
Atherosclerosis
Arteriosclerosis
Coronary Artery Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Coronary Disease
Heart Diseases

ClinicalTrials.gov processed this record on September 14, 2014