Inclusion Criteria:

• Healthy adult: male or female
• Asymptomatic mono-infection with P. falciparum parasitemia with a parasite density of 1000 - 30,000 parasites/μL
• Age 18 years to 60 years
• Willingness to sign and ability to understand consent form
• Willingness and ability to return for scheduled follow up visits

Exclusion Criteria:

• Mixed malaria infection by Giemsa smear
• History of allergy to or hypersensitivity to chloroquine, Azithromycin or other macrolides (e.g. erythromycin, clarithromycin)
• Any of the following: a.) Antimalarial therapy administered in the past 4 weeks, including quinine therapy or an artemisinin derivative; or b.) An antibacterial with known antimalarial activity (including, erythromycin, doxycycline, clindamycin, cotrimoxazole) within one week prior to enrollment into the study
• Fever, history of fever in past 48 hours, or signs/symptoms of malaria (including acute or subacute headache, nausea, or vomiting)
• Inability to swallow oral medication
• Laboratory evidence or history of significant cardiovascular, liver, hematologic or renal functional abnormality
• Any situation which could prevent the patient from returning to follow up visits
• Pregnancy or breast feeding
• Any other concurrent illness that may confound the result
• Any other condition or circumstance that in the opinion of the Investigator may pose a threat to the study participant or study