Treatment Response to Rehabilitation in Patients With Schizophrenia - Full Text View

Sponsor:	National Institute of Mental Health (NIMH)
Information provided by:	National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:	NCT00063336

Purpose

This study will examine the ways in which schizophrenia-related symptoms affect response to a rehabilitation program for people with schizophrenia.

Condition	Intervention
Schizophrenia	Behavioral: Cognitive Remediation Behavioral: Computer-skills training

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Primary Purpose: Treatment
Official Title:	Treatment Response to Rehabilitation in Schizophrenia

Resource links provided by NLM:

MedlinePlus related topics: Rehabilitation Schizophrenia

U.S. FDA Resources

Further study details as provided by National Institute of Mental Health (NIMH):

Primary Outcome Measures:

Neuropsychological test battery, including measures of visual, verbal memory, and problem-solving abilities [ Time Frame: Measured pre- and post-treatment ] [ Designated as safety issue: No ]
Schizophrenia symptoms [ Time Frame: Measured pre- and post-treament ] [ Designated as safety issue: No ]
UCSD Performance-Based Skills Assessment [ Time Frame: Measured pre- and post-treatment ] [ Designated as safety issue: No ]

Enrollment:	46
Study Start Date:	December 2001
Study Completion Date:	November 2005
Primary Completion Date:	November 2005 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: 1 Participants will receive cognitive remediation treatment.	Behavioral: Cognitive Remediation A computerized cognitive rehabilitation treatment with day-program activities
Experimental: 2 Participants will receive computer-skills training.	Behavioral: Computer-skills training A computerized cognitive rehabilitation treatment with day-program activities

Detailed Description:

Patients with schizophrenia often suffer neurocognitive impairment and psychosocial and vocational difficulties. This study will help identify those patients most likely to benefit from existing behavioral treatments and provide clues for how to modify treatments for those who do not benefit.

Two studies will be conducted. The first will investigate the relationship of symptoms and neurocognitive variables at study entry to psychosocial and vocational status 2 years later. The second study will investigate the relationship of symptoms and neurocognitive variables at study entry to treatment response in patients assigned to either a cognitive remediation track or a computer skills track as part of their rehabilitation treatment.

Both the cognitive remediation and computer skills training programs will last 4 to 6 months. Participants will be assessed pre- and post-treatment. Neuropsychological, psychosocial and vocational status will be measured.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

DSM-IV criteria for schizophrenia or schizoaffective disorder
In need of intensive outpatient care
Treatment with atypical antipsychotic medication for a minimum of 6 months prior to study entry

Exclusion Criteria:

Auditory or visual impairment
Mental retardation (IQ less than 70)
Traumatic brain injury with loss of consciousness
Presence or history of any neurological illness that may affect brain physiology
Lack of proficiency in English
Concurrent substance abuse and/or dependence

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00063336

Locations

United States, Connecticut
Schizophrenia Rehabilitation Program, Institutes of Living
Hartford, Connecticut, United States, 06106

Sponsors and Collaborators

National Institute of Mental Health (NIMH)

Investigators

Principal Investigator:

Matthew M. Kurtz, PhD

Schizophrenia Rehabilitation Program, Institutes of Living

More Information

No publications provided

Responsible Party:	Matthew M. Kurtz, PhD, Schizophrenia Rehabilitation Program, Institutes of Living
ClinicalTrials.gov Identifier:	NCT00063336 History of Changes
Other Study ID Numbers:	R03 MH065377, DSIR AT-SP
Study First Received:	June 25, 2003
Last Updated:	May 4, 2009
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on February 12, 2012