Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

This study has been completed.

First Received on July 18, 2002. Last Updated on March 22, 2006 History of Changes

Sponsor:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00041821

Purpose

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Condition	Intervention
Rhinitis, Allergic, Nonseasonal	Procedure: Nasal irritation thresholds and irritant provocation

Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Crossover Assignment Masking: Single Blind
Official Title:	Individual Factors in Nasal Irritant Sensitivity

Resource links provided by NLM:

MedlinePlus related topics: Allergy

U.S. FDA Resources

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	64
Study Start Date:	September 2000

Eligibility

Ages Eligible for Study:	18 Years to 69 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Non-smokers
18-69 years of age
With or without allergic rhinitis (hay fever)
In good general health and with no prior history of asthma

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00041821

Locations

United States, California
Upper Airway Biology Laboratory
Richmond, California, United States, 94804

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

More Information

Additional Information:

Website of UCSF Upper Airway Biology Laboratory This link exits the ClinicalTrials.gov site

Publications:

Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40.

Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9.

ClinicalTrials.gov Identifier:	NCT00041821 History of Changes
Other Study ID Numbers:	10424-CP-001
Study First Received:	July 18, 2002
Last Updated:	March 22, 2006
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

rhinitis
irritation
trigeminal

Additional relevant MeSH terms:

Rhinitis
Rhinitis, Allergic, Perennial
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections

Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on February 12, 2012