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BMS-247550 Plus Carboplatin in Treating Patients With Recurrent or Refractory Solid Tumors
This study has been completed.

First Received on January 4, 2002.   Last Updated on July 23, 2008   History of Changes
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Collaborator: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00028561
  Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of BMS-247550 when given together with carboplatin in treating patients with recurrent or refractory solid tumors.


Condition Intervention Phase
Unspecified Adult Solid Tumor, Protocol Specific
Drug: carboplatin
Drug: ixabepilone
Phase I

Study Type: Interventional
Study Design: Primary Purpose: Treatment
Official Title: A Phase I Study of Epothilone B Analog BMS 247550 in Combination With Carboplatin in Recurrent and/or Refractory Solid Tumors

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Study Start Date: January 2002
Detailed Description:

OBJECTIVES:

  • Determine the maximum tolerated dose of BMS-247550 when given in combination with carboplatin in patients with recurrent or refractory solid tumors.
  • Determine the dose-limiting toxicity and safety of this regimen in these patients.
  • Determine the plasma pharmacokinetics of this regimen in these patients.
  • Determine, preliminarily, any antitumor activity of this regimen in these patients.
  • Correlate the protein expression of survivin with the expression of other apoptotic regulators, the apoptotic index, and response in patients treated with this regimen.

OUTLINE: This is a dose-escalation study of BMS-247550.

Patients receive BMS-247550 IV over 1 hour on days 1, 8, and 15 followed by carboplatin IV over 1 hour on day 1. Treatment repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients with a complete response (CR) receive 2 additional courses after achieving CR or up to a total of 6 courses.

The first two cohorts of 3-6 patients each receive escalating doses of BMS-247550 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity (DLT).

The third and fourth cohorts of 10 patients each receive escalating doses of BMS-247550 until the MTD is determined. The MTD is defined as the dose preceding that at which at least 3 of 10 patients experience DLT. Once the MTD is determined for the third and fourth cohorts, 15 additional patients are treated at the MTD.

Patients are followed for 30 days.

PROJECTED ACCRUAL: Approximately 18-45 patients will be accrued for this study within 6-15 months.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed metastatic or unresectable solid tumor for which standard curative or palliative measures do not exist or are no longer effective
  • Measurable or evaluable disease
  • Lesion accessible for core or excisional biopsy if being treated at the maximum tolerated dose (MTD)

    • No biliary tract dilation if radiologically guided biopsy of the liver is planned
    • No requirement for core biopsy of lung lesion that is not pleural based
    • No requirement for laparotomy or thoracotomy solely for biopsy
    • No medical condition that would preclude biopsy
  • No known brain metastases

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance status:

  • ECOG 0-2
  • ECOG 0-1 if being treated at the MTD

Life expectancy:

  • More than 3 months

Hematopoietic:

  • Absolute neutrophil count at least 1,500/mm^3
  • Platelet count at least 100,000/mm^3
  • No prior bleeding disorder or unexplained bleeding if being treated at the MTD

Hepatic:

  • Bilirubin no greater than 1.5 mg/dL
  • AST/ALT no greater than 2 times upper limit of normal (ULN) (5 times ULN if liver metastases present)
  • PT/PTT normal

Renal:

  • Creatinine no greater than 1.5 times ULN OR
  • Creatinine clearance at least 60 mL/min

Cardiovascular:

  • No symptomatic congestive heart failure
  • No unstable angina pectoris
  • No cardiac arrhythmia

Other:

  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No other concurrent uncontrolled illness that would preclude study participation
  • No ongoing or active infection
  • No grade 2 or greater neuropathy (sensory or motor)
  • No prior severe allergic reaction attributable to compounds containing Cremophor EL or platinum agents
  • No psychiatric illness or social situation that would preclude study compliance
  • No medical condition that would preclude study if being treated at the MTD

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • At least 4 week since prior immunotherapy
  • At least 24 hours since prior growth factors

Chemotherapy:

  • At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
  • No more than 3 prior chemotherapy regimens
  • No prior epothilone agents

Endocrine therapy:

  • At least 1 week since prior hormonal therapy directed at malignancy
  • Concurrent hormone replacement therapy allowed

Radiotherapy:

  • At least 4 weeks since prior wide-field radiotherapy involving 30% or more of bone marrow

Surgery:

  • See Disease Characteristics

Other:

  • At least 4 weeks since prior investigational agents
  • No prior or concurrent St. John's Wort
  • No concurrent combination anti-retroviral therapy for HIV-positive patients
  • No other concurrent investigational agents
  • No concurrent heparin or other anticoagulants if being treated at the MTD
  • No concurrent inhibitors of cytochrome P450 3AP (CYP3A4)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00028561

Locations
United States, Florida
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612-9497
Sponsors and Collaborators
H. Lee Moffitt Cancer Center and Research Institute
Investigators
Study Chair: Daniel M. Sullivan, MD H. Lee Moffitt Cancer Center and Research Institute
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00028561     History of Changes
Other Study ID Numbers: CDR0000069105, MCC-12657, NCI-5306
Study First Received: January 4, 2002
Last Updated: July 23, 2008
Health Authority: United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
unspecified adult solid tumor, protocol specific

Additional relevant MeSH terms:
Neoplasms
Carboplatin
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on February 12, 2012