Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

This study has been completed.

First Received on July 3, 2001. Last Updated on January 20, 2009 History of Changes

Sponsor:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018785

Purpose

Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired immunological tolerance) is a desirable therapeutic option. This project extends recent observations supporting the use of concommitant donor bone marrow cell infusion as a means of modulating the immune response in kidney transplantation, thereby allowing a substantial decrease or withdrawal of potentially toxic immunosuppressive drugs.

Condition	Intervention
Kidney Disease	Procedure: donor bone marrow infusion

Study Type:	Interventional
Study Design:	Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Prevention
Official Title:	Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

Resource links provided by NLM:

MedlinePlus related topics: Kidney Transplantation

U.S. FDA Resources

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	October 1998
Estimated Study Completion Date:	September 2003

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Living related donor kidney transplant recipients and the living related donors.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018785

Locations

United States, Florida
VAMC Miami
Miami, Florida, United States, 33125

Sponsors and Collaborators

Department of Veterans Affairs

Investigators

Investigator:	Camillo Ricordi, M.D.
Investigator:	Andreas Tzakis, M.D.
Investigator:	Violet Esquenazi, Ph.D.
Investigator:	Keith Zucker, Ph.D.

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00018785 History of Changes
Other Study ID Numbers:	IMMU-035-98S
Study First Received:	July 3, 2001
Last Updated:	January 20, 2009
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

kidney transplantation
immunosuppression
bone marrow

Additional relevant MeSH terms:

Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on February 09, 2012