Inclusion Criteria

Patients may be eligible for this study if they:

• Are HIV-positive.
• Have been taking anti-HIV medications for at least 12 weeks before study entry and plan to continue taking them for an additional 24 weeks.
• Are male and between 18 and 70 years old.
• Have a measurement of greater than 100 cm around the abdomen.
• Can report an increase in abdominal size after taking antiretroviral drugs.
• Have a viral load less than 10,000 copies/ml within 6 weeks prior to screening.
• Have a serum total testosterone between 125 and 400 ng/dl. If serum total testosterone is greater than 400 ng/dl, bioavailable testosterone must be less than 115 ng/dl or free testosterone must be less than 50 pg/ml.

Exclusion Criteria

Patients will not be eligible for this study if they:

• Take certain drugs, including testosterone derivatives, glucocorticoids, appetite stimulants, dronabinol, megestrol acetate, androstenediols, oxandrolone, or other anabolic agents such as dehydroepiandrosterone (DHEA) or growth hormone within 12 weeks prior to study entry.
• Take hydroxyurea within 30 days of study entry.
• Take drugs for diabetes.
• Have diabetes.
• Take granulocyte-macrophage colony-stimulating factor (GM-CSF). (Granulocyte colony-stimulating factor (G-CSF) is allowed.)
• Take cytokines, cytokine inhibitors, or ketoconazole.
• Take ritonavir with simvastatin or lovastatin.
• Have an active opportunistic infection. Patients on treatment for at least 12 weeks will be allowed.
• Have 5-7 loose stools per day or diarrhea for more than 1 week, within 6 weeks of study entry.
• Have a blood pressure greater than 160 over 100.
• Have certain heart problems.
• Have a breast mass that has not been diagnosed.
• Have active cancer.
• Have had prostate cancer or certain other prostate problems.
• Are allergic to any part of the testosterone gel.
• Have a history of blood clots.
• Have a history of sleep apnea.
• Are receiving experimental treatment.
• Are receiving experimental drugs in other studies and do not know if they are taking the drug or placebo.
• Abuse drugs or alcohol in a way that would interfere with the study.
• Are dieting or doing heavy exercising.
• Have a viral load of 10,000 copies/ml or more at screening