The Relationship Between Vitamin D, Fingernail Thickness and Bone Density

This study has been completed.

First Received on September 7, 2000. Last Updated on June 23, 2005 History of Changes

Sponsor:	National Center for Research Resources (NCRR)
Information provided by:	National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:	NCT00006196

Purpose

Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population. An unknown number of elderly have vitamin D resistance resulting in a functional vitamin D deficiency state. Because there are no simple procedures or blood tests that identify vitamin D resistance, its prevalence and contribution to disability in the elderly is unknown. Our inability to screen for this condition precludes our ability to initiate and monitor treatment.

Previous studies indicate that fingernail thickness correlates with vitamin D status and may therefore provide a simple cost effective procedure to not only identify patients with vitamin D deficiency but also, those with vitamin D resistance. This procedure may also provide a way to monitor an individual's response to treatment.

This study is designed to demonstrate the association between fingernail thickness and vitamin D status.

Condition	Intervention	Phase
Osteoporosis	Drug: Vitamin D	Phase I

Study Type:	Interventional
Study Design:	Allocation: Randomized Masking: Double-Blind Primary Purpose: Diagnostic

Resource links provided by NLM:

MedlinePlus related topics: Bone Density Osteoporosis Vitamin D

Drug Information available for: Vitamin D

U.S. FDA Resources

Further study details as provided by National Center for Research Resources (NCRR):

Eligibility

Ages Eligible for Study:	25 Years to 75 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

females 25-75 years of age with no known bone disorders

Exclusion Criteria:

history of vertebral fractures or nonvertebral fractures without trauma
prescription medications for prevention of osteoporosis (including vitamin D other than multivitamin and estrogen)
history of malignancy other than basal cell or squamous cell cancer of the skin
use of steroids or anticonvulsants in the 6 months prior to enrollment

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00006196

Locations

United States, Missouri
4488 Forest Park, Suite 201
St. Louis, Missouri, United States, 63108

Sponsors and Collaborators

National Center for Research Resources (NCRR)

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00006196 History of Changes
Other Study ID Numbers:	NCRR-M01RR00036-0754, M01RR00036
Study First Received:	September 7, 2000
Last Updated:	June 23, 2005
Health Authority:	United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):

Vitamin D resistance

Additional relevant MeSH terms:

Osteoporosis
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Vitamin D
Ergocalciferols

Vitamins
Bone Density Conservation Agents
Physiological Effects of Drugs
Pharmacologic Actions
Micronutrients
Growth Substances

ClinicalTrials.gov processed this record on February 12, 2012