Bogalusa Heart Study

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005129
First received: May 25, 2000
Last updated: January 27, 2006
Last verified: January 2006
  Purpose

To determine the natural history of atherosclerosis, coronary artery disease, and hypertension in children and adults from birth to age 40 in a total biracial community.


Condition
Atherosclerosis
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Hypertension

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: June 1972
Estimated Study Completion Date: July 2002
  Hide Detailed Description

Detailed Description:

BACKGROUND:

The Bogalusa Heart Study has been a long-term epidemiologic study. The investigators have identified and followed Black and white children for nearly 30 years, and have described the incidence and prevalence of biologic and behavioral cardiovascular disease risk factors in these children. Their population has enabled them to not only document differences between males and females, but also between Blacks and whites. The results from the Bogalusa Heart Study have clearly documented that the genesis of atherosclerosis has its basis in childhood, and that prevention can and must begin at the early ages.

The Bogalusa Heart Study had been funded over the years by the Specialized Centers of Research (SCOR) Program. The SCOR program was initiated by NHLBI in 1970 to expedite the development and application of new knowledge essential for improved diagnosis, treatment, and prevention of arteriosclerosis, hypertension, pulmonary disease, and thrombosis. In 1984 a Demonstration and Education Component was added to the parent SCOR of the Bogalusa Heart Study in order to translate the experience gained in epidemiological studies into an intervention study designed to retard the development of cardiovascular risk factors in children. Beginning in 1987, the Bogalusa Heart Study was supported by a regular research grant. Beginning in 1997, the study is supported by the cooperative agreement mechanism.

DESIGN NARRATIVE:

The initial survey in 1973-1974 was restricted to children ages 2 1/2 to 14. A physical examination was conducted and information was collected on anthropometric data, hemoglobin, blood pressure, serum lipids, and health history. Over 3,500 children participated. The second cross-sectional survey of 1976-1977 and subsequent surveys expanded the eligible population to include all children ages 5-17 years. The second survey of over 4,000 children also included information on salt intake, smoking, health beliefs, and attitudes, and for girls ages 8-17, menstrual history and oral contraceptive use. The third survey of over 3,500 children in 1978-1979 also collected anthropometric measurements on skinfold thickness and two measurements of heart rate. The fourth survey of over 3,300 children in 1981-1982 added data on alcohol use, Type A behavior, peer networks and dieting habits.

The Bogalusa Heart Study continued to use a cross-sectional and longitudinal design with the general cross-sectional survey of approximately 3,700 Bogalusa children ages five to seventeen in 1988-1989 in the sixth screen and additional longitudinal studies to recall children in defined subgroups for more intensive evaluation. Half of the 12,000 children screened since 1973 had been studied three or more times. There were several other cohort groups and studies. The Newborn-Infant Cohort Study was designed to describe distributions, inter-relationships, and trends through time for blood pressure, serum lipid and lipoprotein concentrations, dietary intake patterns, and anthropometric measurements. Four hundred and forty infants born between January 1, 1974 through June 30, 1975 were examined at birth, at six months, and yearly at ages one through four and at seven, ten and thirteen years for cardiovascular risk factor variables. The Post High School Study examined young adults ages 21 through 30 who previously were examined as children ages five through fourteen in the first Bogalusa Heart Study screening in 1973-1974. The population included approximately 4,603 young adults originally screened and any other children or adolescents examined for the first time in any subsequent surveys.

The fifth screening began in 1988 and extended through December 1991. The Pediatric Pathology Risk Factor Program, which began in 1978, documented the relationship of cardiovascular disease risk factors to anatomic and pathologic changes. A local information system was established to obtain family or coroner's consent to autopsy any deceased resident between the ages of three and 26 in the Bogalusa area. Autopsy specimens were collected from over 100 deceased children and young adults, of whom approximately forty percent had been previously examined in the Bogalusa Heart Study. Major activity during 1988-1991 involved 24-hour dietary recall collections on all the 1963, 1966, and 1968 birth cohorts attending the Post High School Study. A food frequency questionnaire was also self-administered to all the Post High School Study participants. The use of these two dietary methodologies, 24-hour dietary recall and food frequency questionnaire, provided data to assess the nutrient composition of diets of young adults, assess the weekly consumption of individual foods, compare nutrient composition data with food frequency data, and compare dietary intakes at the post high school age with those of school age. Several substudies were conducted using the Bogalusa Heart Study population. Among them were the impact of childhood obesity on risk factors, the relationship of apolipoproteins A-I and B in children to parental myocardial infarction and the relationship between left ventricular size as demonstrated by echocardiography and blood pressure distribution.

The study was renewed in Fiscal Year 1992 in order to follow-up the previously examined young adults for development of abnormal levels of cardiovascular risk factors and even clinical disease.

In 1997, the study was renewed and extended through June 2002 in order to study the impact of genetic factors on the evolution from childhood cardiovascular risk factors to subclinical and clinical morbidity in an adult population, ages 20 to 40, who had been followed over a long period of time. The study also seeks to study the association of risk factor phenotypes to anatomic changes in the cardiovascular system as seen by necropsy. The population for genotype-phenotype studies includes approximately 1,400 siblings derived from 178 longitudinal birth cohorts. The cardiovascular phenotypes include obesity, blood pressure, lipids, lipoproteins, apoproteins, homocysteine, glucose-insulin, fibrinogen, plasminogen activator inhibitor-1 and von Willebrand Factor. Environmental risk factors consist of sociodemographic characteristics, tobacco and alcohol use, oral contraception, physical activity and diet. Subclinical morbidity includes echo-Doppler measurements of cardiac-carotid structure and function. Using robust sibling pair linkage methods, a genome-wide search involving 391 markers with spacing of 10 centimorgans is conducted for genes which influence quantitative traits. This is supplemented with 41 highly polymorphic markers located in or near candidate genes likely to be related to obesity, lipoprotein metabolism, blood pressure, insulin resistance, diabetes, atherogenesis and thrombosis. The study is shifting from a population-based epidemiologic study to a family-based genetic epidemiologic study.

Approximately 75 percent of the dollars of a Specialized Center of Research (SCOR) in Arteriosclerosis (P50HL14103) were used to support the Bogalusa Heart Study from 1972 through 1986.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005129

Sponsors and Collaborators
Investigators
Investigator: Gerald Berenson Tulane University
  More Information

Publications:
Hunter SM, Croft JB, Burke GL, Vizelberg IA, Berenson GS: Social Influences and Longitudinal Patterns of Smokeless Tobacco Use. In: Health Implications of Smokeless Tobacco, NIH Consensus Development Conference, January 13-15, p. 32-37, 1986
Freedman DS, Newman WP III, Gard PD, Cresanta JL, Srinivasan SR, Tracy RE, Berenson GS: Atherosclerosis in Early Life - The Bogalusa Heart Study. Cardiol Board Rev, 3:26-40, 1986
Cohen JC, Buonagura K, Bickers J, Berenson GS, Rothschild H: Familial Clustering of Malignancies: Distribution of Ha-ras Restriction Fragment Length Polymorphisms in Normal and High Risk Populations. In: Proceedings of UCLA Symposia on Molecular and Cellular Biology, Vol 40 (Harris CC, Eds). New York: Alan R. Liss, Inc, p. 397-400, 1986
Webber LS, Freedman DS, Cresanta JL: Tracking of Cardiovascular Disease Risk Factor Variables in School-Age Children. In: Causation of Cardiovascular Risk Factors in Children (Berenson GS, Ed). New York: Raven Press, 1986
Webber LS, Freedman DS: Interrelationships of Coronary Heart Disease Risk Factors in Children. In: Causation of Cardiovascular Risk Factors in Children (Berenson GS, Ed). New York: Raven Press, 1986
Freedman DS, Srinivasan SR, Shear CL, Franklin FA, Webber LS, Berenson GS: Apolipoproteins A-I and B in Relation to Parental Myocardial Infarction - The Bogalusa Heart Study. Cardiol Board Rev, March:1-24, 1987
Berenson GS, Srinivasan SR, Shear CL, Webber LS: The Epidemiology of Coronary Artery Disease in Childhood. In: Cardiovascular Risk Factors in Childhood: Epidemiology and Prevention (Hetzel BS, Berenson GS, Eds). Amsterdam: Elsevier Science Publishers, B.V., p. 3-20, 1987
Freedman DS, Newman WP III, Tracy RE, Strong JP, Cresanta JL, Berenson GS: Pathology of Atherosclerosis in Childhood. In: Cardiovascular Risk Factors in Childhood: Epidemiology and Prevention (Hetzel BS, Berenson GS, Eds). Amsterdam: Elsevier Science Publishers, B.V., p. 83-99, 1987
Thompson B, Butcher AH, Berenson GS: Children's Beliefs About Sources of Health: A Reliability and Validity Study. Measure Eval Guid Develop, 20(20:80-88, 1987
Nicklas TA, Arbeit ML, Franklin FA, Johnson CC, Berenson GS: A Family Approach to Cardiovascular Risk Reduction Through Diet. J Nutr Educ GEM, 19:302A, 1987
Srinivasan SR, Freedman DS, Berenson GA: Are Plasma Apolipoproteins Helpful as Markers of Coronary Artery Disease? Int Med, 8:195-201, 1987
Johnson CC, Nicklas TA, Arbeit ML, Franklin FA, Berenson GS: A Comprehensive Model for Maintenance of Family Health Behaviors; The 'Heart Smart' Family Health Promotion Program. Family Commun Hlth, 11:1-7, 1988
Nicklas TA, Arbeit ML, Johnson CC, Franklin FA, Berenson GS: Intervention on Family Eating Behavior for Children at High Risk: Heart Smart Program. J Nutr Educ, 20:128-132, 1988
Voors AW, Webber LS, Berenson GS: A Consideration of Essential Hypertension in the Pediatric Age. Practical Cardiol, 3:29, 1977
Frerichs RR, Srinivasan SR, Webber LS, Berenson GS: Serum Cholesterol and Triglyceride Levels in Children From a Biracial Community - The Bogalusa Heart Study. International Workshop-Conference on Atherosclerosis, London, Ontario, Canada, September 1975. Atherosclerosis. (G.W. Manning and M.D. Haust Eds.) Plenum Publ. Corp, New York, p. 204, 1977
Berenson GS: Risk Factors in Children - the Early Natural History of Arteriosclerosis. Tokyo. In: Atherosclerosis IV, (G Schettler, Goto Y, Hata G, Klose, Eds.) Springer-Verlag, Berlin, Heidelberg, p. 489, 1977
Voors AW, Webber LS, Berenson GS: Relationship of Blood Pressure Levels to Height and Weight in Children. Cardiovasc Med, 3:911, 1978
Frank GC, Farris RP, Berenson GS: Dietitians' Response to Knowledge of Their Own Cardiovascular Risk. J Nutr Ed, 10:105, 1978
Berenson GS, Webber LS, Srinivasan SR, Frerichs RR, Voors AW: Interrelationship and Persistence of Risk Factor Variables at High Levels in Children - The Bogalusa Heart Study The 5th International Conference on Atherosclerosis, Milan, Italy, November 1977, (L. A. Carlson, R. Paoletti, C. R. Sirtori, and G. Weber, Eds.) Raven Press, New York, p. 357, 1978
Srinivasan SR, Berenson GS, Frerichs RR: Serum Lipids and Lipoproteins in Children. In: Atherosclerosis: Its Pediatric Aspects (W. B. Strong, Ed.) Grune and Stratton, New York, p. 85, 1978
Berenson GS: Children, the Next Generation of Patients with Myocardial Infarction. Proceedings of the International Kronberg Symposium, Frankfurt, Germany, May 1977. Changes in the Medical Panorama, (G. Schettler, J. Drews, and H. Greten, Eds.) Georg Thieme Publishers, Stuttgart, Germany, p. 75, 1978
Berenson GS, Voors AW, Webber LS: Blood Pressure Levels in Black and White Children Related to the Early Onset of Essential Hypertension. Proceedings, VIII World Congress of Cardiology, Tokyo. (S. Hayase and S. Murae, Eds.) Excerpta Medica, Amsterdam, p. 406-413, 1979
Berenson GS, Srinivasan SR, Webber LS: Prognostic Significance of Lipid Profiles in Children. In: Childhood Prevention of Atherosclerosis and Hypertension, (R.M. Lauer, and R.B. Shekelle, Eds.) Raven Press, New York, p. 75-86, 1980
Berenson GS, Srinivasan SR, Voors AW, Webber LS: Clues to Mechanisms of Cardiovascular Disease From an Epidemiologic Study of Children - The Bogalusa Heart Study. In: Atherosclerosis V (Gotto AM Jr, Smith LC, Allen B, Eds). New York: Springer-Verlag, p. 272-277, 1980
Voors AW, Berenson GS, Shuler SE, Webber LS: Blood Pressure, Electrolyte Clearance, and Plasma Renin Activity in Children Sampled From an Entire Community J Appl Biochem, 2:87-99, 1980
Voors AW, Webber LS, Berenson GS: Epidemiologia de la Hipertension Arterial en Ninos Estadunidenses. In: Hipertension Arterial 1980. First Interamerican Course on Hypertension, Mexico City, Feb. 1979 (Gonzalez Caamano A, Alcocer DB, L, Eds). Mexico City: Ediciones Medicas Actualizadas, SA, p.91-102, 1980
Voors AW, Webber LS, Berenson GS: Epidemiologia de la Hipertension Arterial an Adolescentes Estadunidenses. In: Hipertension Arterial 1980, First Interamerican Course on Hypertension, Mexico City, Feb. 1979 (Gonzalez Caamano A, Alcocer DB, L, Eds). Mexico City: Ediciones Medicas Actualizadas, SA, p. 103-115, 1980
Berenson GS, Voors AW, Webber LS: Importance of Blood Pressures in Children - Distribution and Measurable Determinants. In: Epidemiology of Arterial Blood Pressure (Kesteloot H, Joossens JV Eds). The Hague, Netherlands: Martinus Nijhoff Publishers, p. 71-97, 1980
Voors AW, Webber LS, Harsha DW, Frank GC, Berenson GS: Obesity: Determinants and Consequences in Children of An Entire Biracial Population - The Bogalusa Heart Study. J Chron Dis Ther Res, 4:169-191, 1980
Berenson GS, Voors AW, Webber LS: Hypertension in the Young - Measurement and Criteria. In: Phasic Pressor Mechanisms: Hypertension in the Young and the Old (Onesti G, Kim KE, Eds). New York: Grune and Stratton, p. 3-10, 1981
Voors AW, Berenson GS: Search for the Determinants of the Early Onset of Essential Hypertension. In: Phasic Pressor Mechanisms: Hypertension in the Young and the Old (Onesti G, Kim KE, Eds). New York: Grune and Stratton, p. 43-55, 1981
Berenson GS, Voors AW, Webber LS: Epidemiology in a Biracial Community in the Rural South of the United States. In: Phasic Pressor Mechanisms: Hypertension in the Young and Old (Onesti G, Kim KE, Eds). New York: Grune and Stratton, p. 183-190, 1981
Berenson GS, Srinivasan SR, Frank GC, Webber LS: Serum Lipid and Lipoprotein in Infants and Children and Their Relationship with Diet. In: Nutrition and Child Health: Perspectives in the 1980's, Vol 61 (Tsang RC, Nichols BL Jr, Eds). New York: Alan R. Liss, p. 73-94, 1981
Berenson GS, Voors AW, Webber LS: Blood Pressure in Children and Factors Predisposing to Hypertensive Disease in Adults. In: Paediatric Cardiology, Vol 4 (Godman MJ, Ed). Edinburgh: Churchill Livingstone, p. 591-600, 1981
Berenson GS, Webber LS, Voors AW: Diagnostic Challenge: Diagnosing Hypertension in Children. J Cardiovasc Med, 7:273-279, 1982
Wolf TM, Sklov MC, Hunter SM, Berenson GS: Factor Analytic Study of the Children's Nowicki-Strickland Locus of Control Scale. Educ Psychol Measure, 42:333-337, 1982
Voors AW, Sklov MC, Wolf TM, Hunter SM, Berenson GS: Cardiovascular Risk Factors in Children and Coronary Related Behavior. In: Promoting Adolescent Health: A Dialogue on Research and Practice (Coates T, Petersen A, Perry C, Eds). New York: Academic Press, p. 281-304, 1982
Frank GC, Berenson GS, Webber LS: Dietary Studies of Infants and Children. In: Promoting Adolescent Health: A Dialogue on Research and Practice (Coates T, Petersen A, Perry C, Eds). New York: Academic Press, p. 329-354, 1982
Frank GC, Webber LS, Berenson GS: Dietary Studies of 10-Year-Old Children in the Bogalusa Heart Study. In: Nutrition and Heart Disease (Naito HK, Ed). Jamaica, New York: Spectrum Publications, p. 91-110, 1982
Berenson GS, Voors AW, Frank GC, Webber LS: Studies of Blood Pressure and Dietary Sodium Intake in Children in Semirural Southern United States: The Bogalusa Heart Study. In: The Role of Salt in Cardiovascular Hypertension (Fregly MJ, Kare MR, Eds). New York: Academic Press, p. 49-62, 1982
Wolf TM, Sklov MC, Hunter SM, Webber LS, Berenson GS: Factor Analytic Study of the Piers-Harris Children's Self-Concept Scale. J Pers Assess, 46:511-513, 1982
Berenson GS: Racial Differences in Hypertension. In: Hypertension: Prevention, Diet, and Treatment in Infancy and Childhood, (Blumenthal S, Chairman and Ed). Proceedings from a Symposium Sponsored by Wyeth Laboratories, Bethesda, MD, May 25, 1983. Library of Congress No. 83-072205, p. 24-28, 1983
Berenson GS, Voors AW, Gard P, Newman WP III, Tracy RE: Clinical and Anatomic Correlates of Cardiovascular Disease in Children from the Bogalusa Heart Study. In: Atherosclerosis VI (Schettler FG, Gotto AM Jr, Middlehoff G, Habenicht AGR, Jurutke KR, Eds). New York: Springer-Verlag, p. 60-65, 1983
Srinivasan SR, Berenson GS: Serum Lipoproteins in Children and Methods for Study. In: CRC Handbook of Electrophoresis (Lipoproteins), Vol III (Lewis LA, Opplt JJ, Eds). Boca Raton, Florida: CRC Press, p. 185-203, 1983
Berenson GS, Webber LS, Frank GC, Farris RP: Management of the Mildly Hypertensive Youth: Can Adult Hypertensive Disease be Prevented? In NHLBI Workshop on Juvenile Hypertension (Loggie JMH, Horan MJ, Gruskin AB, Hohn AR, Dunbar JB, Havlik RJ, Eds). New York: Biomedical Information Corp., p. 387-407, 1984
Farris RP, Frank GC, Webber LS, Berenson GS: Quality Controls for Processing Dietary Data. J Diet Software, 1:3-4, 1984
Farris RP, Frank GC, Berenson GS: Halt the Salt. J Nutr Ed, 16:174a, 1984
Parker FC, Harsha DW, Farris RP, Webber LS, Frank GC, Berenson GS: Reducing the Risk of Cardiovascular Disease in Children. In: Self-Management of Chronic Disease (Holroyd K, Creer T, Eds). Orlando, FL: Academic Press, 1986
Berenson GS, Frank GC: Racial (Black-White) Differences in Blood Pressure in Children. In: Potassium in Cardiovascular and Renal Medicine: Arrhythmias, Myocardial Infarction, and Hypertension (Whelton PK, Whelton A, Walker WG, Eds). New York: Marcel Dekker, Inc., p. 365-380, 1986
Berenson GS, Wattigney W, Newman WP III, Tracy RE, Srinivasan SR, Webber LS: Relationship of Atherosclerosis and Risk Factors in Young Adults: Racial, Sex, and Anatomic Contrasts. The Bogalusa Heart Study. Symposium on Hypertension and Atherosclerosis CIC. Edizioni Internazionali, 1988
Cardiovascular Profile of 15,000 Children of School Age in Three Communities, 1971-1975. National Heart, Lung, and Blood Institute DHEW Publication No. (NIH) 78-1472, 1978
Berenson GS, McMahan CA, Voors AW, Webber LS, Srinivasan SR, Frank GC, Foster TA, Blonde CV: Cardiovascular Risk Factors in Children - The Early Natural History of Atherosclerosis and Essential Hypertension (editorial assistance: C. Andrews and H.E. Hester) New York, Oxford Univ. Press, p. 450, 1980
Berenson GS, Blonde CV, Webber LS (Eds): Monograph. Cardiovascular-Profile of Preschool Children in a Biracial Community (Bogalusa, Louisiana) - Bogalusa Heart Study, 1974. New Orleans: Louisiana State University Specialized Center of Research - Arteriosclerosis (SCOR-A). Library of Congress No. 81-52250, 1981
Berenson GS (Eds): Causation of Cardiovascular Risk Factors in Children: Perspectives on Cardiovascular Risk in Early Life. New York: Raven Press, p. 408, 1986
Frank GC, Webber LS, Farris RP, Berenson GS (Eds): Dietary Data Book: Quantifying Dietary Intakes of Infants, Children and Adolescents - The Bogalusa Heart Study, 1973-1983. From the Nutrition Core and Planning and Analysis Core Components of the National Research and Demonstration Center - Arteriosclerosis (NRDC-A). New Orleans: Louisiana State University Medical Center. Library of Congress Catalog Card No. 86-51215, 1986
Farris RP, Frank GC, Ditmarsen P, Berenson GS: Sodium Sense Curriculum: A Dietary Alteration Program Trial (ADAPT). New Orleans: LSU Medical Center. Library of Congress Catalog Card No. 86-82603, 1986
Hetzel BS, Berenson GS (Eds): Cardiovascular Risk Factors in Childhood: Epidemiology and Prevention. Amsterdam: Elsevier Science Publishers, B.V., 1987
Srinivasan SR, Webber LS, Berenson GS: Factors Influencing Serum Lipoprotein Levels in Children. In: Atherosclerosis: A Pediatric Perspective, (Subbiah MTR, Ed). CRC Press, Inc., 1989.

ClinicalTrials.gov Identifier: NCT00005129     History of Changes
Other Study ID Numbers: 908
Study First Received: May 25, 2000
Last Updated: January 27, 2006
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Atherosclerosis
Cardiovascular Diseases
Coronary Disease
Coronary Artery Disease
Heart Diseases
Hypertension
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Myocardial Ischemia

ClinicalTrials.gov processed this record on July 26, 2014