Chemotherapy Plus Radiation Therapy Followed by Surgery in Treating Patients With Soft Tissue Sarcoma
This study has been completed.
Sponsor:
Radiation Therapy Oncology Group
Collaborators:
Eastern Cooperative Oncology Group
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00002791
First received: November 1, 1999
Last updated: June 25, 2010
Last verified: June 2010
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Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with more than one chemotherapy drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy plus radiation therapy followed by surgery in treating patients who have soft tissue sarcoma.
| Condition | Intervention | Phase |
|---|---|---|
|
Sarcoma |
Biological: filgrastim Drug: dacarbazine Drug: doxorubicin hydrochloride Drug: ifosfamide Drug: mesna Procedure: conventional surgery Radiation: brachytherapy Radiation: intraoperative radiation therapy Radiation: radioisotope therapy |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Primary Purpose: Treatment |
| Official Title: | A PHASE II STUDY OF NEOADJUVANT CHEMOTHERAPY AND RADIATION THERAPY IN THE MANAGEMENT OF HIGH-RISK, HIGH-GRADE, SOFT TISSUE SARCOMAS OF THE EXTREMITIES AND BODY WALL |
Resource links provided by NLM:
Drug Information available for:
Ifosfamide
Dacarbazine
Mesna
Doxorubicin
Doxorubicin hydrochloride
Filgrastim
Lenograstim
Granulocyte colony-stimulating factor
U.S. FDA Resources
Further study details as provided by National Cancer Institute (NCI):
| Study Start Date: | February 1997 |
OBJECTIVES: I. Assess whether patients with high-grade soft tissue sarcoma (STS) treated with neoadjuvant mesna/doxorubicin/ifosfamide/dacarbazine (MAID) plus radiotherapy in a cooperative group setting exhibit a response rate, toxicity, and complication rate comparable to those seen in pilot data collected by the Massachusetts General Hospital. II. Assess local control and local complications related to surgery and neoadjuvant MAID plus radiotherapy in these patients. III. Develop a tissue repository of frozen STS for ancillary genetic and flow cytometric analysis of these tumors. IV. Form an Intergroup Working Sarcoma Group that will develop a patient base, relationships, and support for the future development and completion of a phase III study of adjuvant therapy for STS.
OUTLINE: The following acronyms are used: DOX Doxorubicin, NSC-123127 DTIC Dacarbazine, NSC-45388 EBRT External-Beam Radiotherapy (equipment unspecified) G-CSF Filgrastim; Granulocyte Colony-Stimulating Factor (Amgen), NSC-614629 IFF Ifosfamide, NSC-109724 MAID Mesna/DOX/IFF/DTIC Mesna Mercaptoethane sulfonate, NSC-113891 3-Drug Combination Chemotherapy plus Radiotherapy followed by Surgery followed, if indicated, by Radiotherapy followed by 3-Drug Combination Chemotherapy. MAID; plus EBRT to the primary tumor and suspected microscopic disease; followed by minimal wide surgical excision; followed, if positive margins, by postoperative EBRT; followed by MAID.
PROJECTED ACCRUAL: There will be 60 patients accrued into this study within 15 months.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
DISEASE CHARACTERISTICS: Histologically confirmed soft tissue sarcoma of an extremity or the body wall that is a primary or a postoperatively recurrent tumor Biopsy required within 2 months prior to entry Grade II or III tumor, including AJCC stages IIB and IIIB lesions at least 8 cm in diameter No more than 4 chest lesions that are no greater than 3 mm in diameter on preoperative CT The following histologies are excluded: Angiosarcoma of the scalp or face Chondrosarcoma Extraosseous Ewing's sarcoma Head and neck sarcoma Kaposi's sarcoma Osteosarcoma Primitive neuroectodermal tumor Rhabdomyosarcoma Patients on this study are also eligible for Frozen Tumor Repository study (protocol RTOG-9308)
PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 80%-100% Hematopoietic: WBC at least 4,000/mm3 Platelet count at least 150,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL SGOT no greater than 50 U Renal: Creatinine no greater than 1.5 mg/dL Cardiovascular: No congestive heart failure (CHF) within 6 months No myocardial infarction (MI) within 6 months No New York Heart Association class II-IV heart disease Left ventricular ejection fraction at least 50% by MUGA or echocardiogram If history of CHF or MI, criterion must be met within past 6 months Other: No contraindication to surgery No uncontrolled bacterial, viral, or fungal infection No serious medical or psychiatric illness that precludes informed consent or limits survival to less than 2 years No second malignancy within 5 years except: Surgically treated in situ cervical cancer Nonmelanomatous skin cancer Not pregnant or nursing Negative pregnancy test required of fertile women within 7 days prior to entry Effective contraception required of all fertile patients
PRIOR CONCURRENT THERAPY: Biologic therapy: No prior biologic therapy Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: See Disease Characteristics
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002791
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| United States, Alabama | |
| University of Alabama Comprehensive Cancer Center | |
| Birmingham, Alabama, United States, 35294 | |
| Veterans Affairs Medical Center - Birmingham | |
| Birmingham, Alabama, United States, 35233 | |
| Huntsville Hospital System | |
| Huntsville, Alabama, United States, 35801 | |
| MBCCOP - University of South Alabama | |
| Mobile, Alabama, United States, 36688 | |
| Urology Associates - Mobile AL | |
| Mobile, Alabama, United States, 36640 | |
| Alabama Oncology, LLC | |
| Montgomery, Alabama, United States, 36106-2801 | |
| Radiation Oncology Associates of West Alabama | |
| Tuscallosa, Alabama, United States, 35401 | |
| United States, Alaska | |
| Providence Cancer Therapy Center | |
| Anchorage, Alaska, United States, 99508 | |
| United States, Arizona | |
| Arizona Cancer Center | |
| Tucson, Arizona, United States, 85724 | |
| United States, California | |
| Providence Saint Joseph Medical Center - Burbank | |
| Burbank, California, United States, 91505 | |
| Mount Diablo Medical Center | |
| Concord, California, United States, 94524-4110 | |
| Beckman Research Institute, City of Hope | |
| Duarte, California, United States, 91010 | |
| California Cancer Center | |
| Fresno, California, United States, 93720 | |
| Saint Agnes Cancer Center | |
| Fresno, California, United States, 93720 | |
| Glendale Memorial Hospital and Health Center | |
| Glendale, California, United States, 91204 | |
| Sutter Health Western Division Cancer Research Group | |
| Greenbrae, California, United States, 94904 | |
| Loma Linda University Medical Center | |
| Loma Linda, California, United States, 92354 | |
| Veterans Affairs Medical Center - Long Beach | |
| Long Beach, California, United States, 90822 | |
| Jonsson Comprehensive Cancer Center, UCLA | |
| Los Angeles, California, United States, 90095-1781 | |
| Kaiser Permanente Medical Center - Los Angeles | |
| Los Angeles, California, United States, 90027 | |
| USC/Norris Comprehensive Cancer Center | |
| Los Angeles, California, United States, 90033-0800 | |
| Veterans Affairs Outpatient Clinic - Martinez | |
| Martinez, California, United States, 94553 | |
| CCOP - Bay Area Tumor Institute | |
| Oakland, California, United States, 94609-3305 | |
| Cancer Care Center | |
| Pomona, California, United States, 91767 | |
| Mercy Medical Center - Redding | |
| Redding, California, United States, 96099-6009 | |
| Radiation Oncology Center - Sacramento | |
| Sacramento, California, United States, 95816 | |
| UCSF Cancer Center and Cancer Research Institute | |
| San Francisco, California, United States, 94115-0128 | |
| Santa Cruz Radiation Oncology Medical Group, Inc. | |
| Santa Cruz, California, United States, 95065 | |
| CCOP - Santa Rosa Memorial Hospital | |
| Santa Rosa, California, United States, 95403 | |
| Stanford University | |
| Stanford, California, United States, 94305 | |
| David Grant Medical Center | |
| Travis Air Force Base, California, United States, 94535 | |
| Radiation Oncology Center - Walnut Creek | |
| Walnut Creek, California, United States, 94598 | |
| United States, Colorado | |
| Memorial Hospital Cancer Center | |
| Colorado Springs, Colorado, United States, 80909 | |
| University of Colorado Cancer Center | |
| Denver, Colorado, United States, 80262 | |
| United States, Connecticut | |
| Bridgeport Hospital | |
| Bridgeport, Connecticut, United States, 06610 | |
| Whittingham Cancer Center | |
| Norwalk, Connecticut, United States, 06856 | |
| United States, Delaware | |
| CCOP - Christiana Care Health Services | |
| Wilmington, Delaware, United States, 19899 | |
| United States, District of Columbia | |
| Walter Reed Army Medical Center | |
| Washington, District of Columbia, United States, 20307-5000 | |
| United States, Florida | |
| Lykes Center for Radiation Therapy | |
| Clearwater, Florida, United States, 33757-0210 | |
| Halifax Medical Center | |
| Daytona Beach, Florida, United States, 32114 | |
| Radiation Therapy Associates - Fort Myers | |
| Fort Myers, Florida, United States, 33901 | |
| University of Florida Health Science Center | |
| Gainesville, Florida, United States, 32610-0296 | |
| Health First Holmes Regional Medical Center | |
| Melbourne, Florida, United States, 32901 | |
| Baptist Hospital of Miami | |
| Miami, Florida, United States, 33176-2197 | |
| Sylvester Cancer Center, University of Miami | |
| Miami, Florida, United States, 33136 | |
| CCOP - Mount Sinai Medical Center | |
| Miami Beach, Florida, United States, 33140 | |
| Florida Radiation Oncology Group | |
| Orange Park, Florida, United States, 32073 | |
| MD Anderson Cancer Center Orlando | |
| Orlando, Florida, United States, 32806 | |
| Gulf Coast Cancer Treatment Center | |
| Panama City, Florida, United States, 32405-4587 | |
| West Florida Cancer Institute - Pensacola | |
| Pensacola, Florida, United States, 32514 | |
| Bayfront Medical Center | |
| Saint Petersburg, Florida, United States, 33701 | |
| H. Lee Moffitt Cancer Center and Research Institute | |
| Tampa, Florida, United States, 33612 | |
| United States, Georgia | |
| CCOP - Atlanta Regional | |
| Atlanta, Georgia, United States, 30342-1701 | |
| Emory University Hospital - Atlanta | |
| Atlanta, Georgia, United States, 30322 | |
| InterCommunity Cancer Center at Rome | |
| Rome, Georgia, United States, 30161 | |
| South Georgia Medical Center | |
| Valdosta, Georgia, United States, 31603 | |
| United States, Illinois | |
| University of Chicago Cancer Research Center | |
| Chicago, Illinois, United States, 60637 | |
| Northwestern Memorial Hospital | |
| Chicago, Illinois, United States, 60611 | |
| Ingalls Memorial Hospital | |
| Harvey, Illinois, United States, 60426 | |
| Loyola University Medical Center | |
| Maywood, Illinois, United States, 60153 | |
| Lutheran General Cancer Care Center | |
| Park Ridge, Illinois, United States, 60068 | |
| Methodist Medical Center of Illinois | |
| Peoria, Illinois, United States, 61636 | |
| CCOP - Central Illinois | |
| Springfield, Illinois, United States, 62526 | |
| CCOP - Carle Cancer Center | |
| Urbana, Illinois, United States, 61801 | |
| United States, Indiana | |
| St. John's Medical Center | |
| Anderson, Indiana, United States, 46016 | |
| Clarion Health Partners Inc. | |
| Indianapolis, Indiana, United States, 46206-1367 | |
| Community Hospitals of Indianapolis - Regional Cancer Center | |
| Indianapolis, Indiana, United States, 46219 | |
| Ball Memorial Hospital | |
| Muncie, Indiana, United States, 47303-3499 | |
| St. Joseph's Radiation Oncology Center | |
| South Bend, Indiana, United States, 46617 | |
| Memorial Hospital of South Bend | |
| South Bend, Indiana, United States, 46601 | |
| United States, Iowa | |
| CCOP - Cedar Rapids Oncology Project | |
| Cedar Rapids, Iowa, United States, 52403-1206 | |
| Wendt Regional Cancer Center of Finley Hospital | |
| Dubuque, Iowa, United States, 52001 | |
| University of Iowa Hospitals and Clinics | |
| Iowa City, Iowa, United States, 52242 | |
| United States, Kentucky | |
| Medical Center at Bowling Green | |
| Bowling Green, Kentucky, United States, 42102 | |
| Albert B. Chandler Medical Center, University of Kentucky | |
| Lexington, Kentucky, United States, 40536-0084 | |
| Veterans Affairs Medical Center - Lexington | |
| Lexington, Kentucky, United States, 40511-1093 | |
| Louisville Radiation Oncology | |
| Louisville, Kentucky, United States, 40215 | |
| James Graham Brown Cancer Center | |
| Louisville, Kentucky, United States, 40202 | |
| Merle M. Mahr Cancer Center | |
| Madisonville, Kentucky, United States, 42431 | |
| Western Baptist Hospital | |
| Paducah, Kentucky, United States, 42001 | |
| United States, Louisiana | |
| Mary Bird Perkins Cancer Center | |
| Baton Rouge, Louisiana, United States, 70809 | |
| Romagosa Radiation Oncology Center | |
| Lafayette, Louisiana, United States, 70501 | |
| East Jefferson General Hospital | |
| Metairie, Louisiana, United States, 70011 | |
| CCOP - Ochsner | |
| New Orleans, Louisiana, United States, 70121 | |
| MBCCOP - LSU Medical Center | |
| New Orleans, Louisiana, United States, 70112 | |
| United States, Maine | |
| Maine Medical Center | |
| Portland, Maine, United States, 04102 | |
| United States, Maryland | |
| Anne Arundel Oncology Center | |
| Annapolis, Maryland, United States, 21401 | |
| Greater Baltimore Medical Center and Cancer Center | |
| Baltimore, Maryland, United States, 21204 | |
| Harbor Hospital Center | |
| Baltimore, Maryland, United States, 21225 | |
| Johns Hopkins Oncology Center | |
| Baltimore, Maryland, United States, 21287 | |
| Marlene & Stewart Greenebaum Cancer Center, University of Maryland | |
| Baltimore, Maryland, United States, 21201 | |
| Radiation Oncology Affiliates of Maryland, P.A. | |
| Baltimore, Maryland, United States, 21237 | |
| United States, Massachusetts | |
| Joint Center for Radiation Therapy | |
| Boston, Massachusetts, United States, 02215 | |
| Massachusetts General Hospital Cancer Center | |
| Boston, Massachusetts, United States, 02114 | |
| New England Medical Center Hospital | |
| Boston, Massachusetts, United States, 02111 | |
| Cape Cod Hospital | |
| Hyannis, Massachusetts, United States, 02601 | |
| United States, Michigan | |
| CCOP - Ann Arbor Regional | |
| Ann Arbor, Michigan, United States, 48106 | |
| University of Michigan Comprehensive Cancer Center | |
| Ann Arbor, Michigan, United States, 48109-0752 | |
| Veterans Affairs Medical Center - Ann Arbor | |
| Ann Arbor, Michigan, United States, 48105 | |
| Henry Ford Hospital | |
| Detroit, Michigan, United States, 48202 | |
| Barbara Ann Karmanos Cancer Institute | |
| Detroit, Michigan, United States, 48201 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| CCOP - Kalamazoo | |
| Kalamazoo, Michigan, United States, 49007-3731 | |
| Marquette General Hospital | |
| Marquette, Michigan, United States, 49855 | |
| St. Mary's Medical Center | |
| Saginaw, Michigan, United States, 48601 | |
| United States, Minnesota | |
| CCOP - Duluth | |
| Duluth, Minnesota, United States, 55805 | |
| Mayo Clinic Cancer Center | |
| Rochester, Minnesota, United States, 55905 | |
| CCOP - Metro-Minnesota | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| United States, Missouri | |
| Ellis Fischel Cancer Center - Columbia | |
| Columbia, Missouri, United States, 65203 | |
| CCOP - Kansas City | |
| Kansas City, Missouri, United States, 64131 | |
| Mallinckrodt Institute of Radiology | |
| Saint Louis, Missouri, United States, 63110 | |
| St. Louis University Health Sciences Center | |
| Saint Louis, Missouri, United States, 63110-0250 | |
| Veterans Affairs Medical Center - Saint Louis | |
| Saint Louis, Missouri, United States, 63106 | |
| Cancer Research for the Ozarks | |
| Springfield, Missouri, United States, 65807 | |
| CCOP - Ozarks Regional | |
| Springfield, Missouri, United States, 65807 | |
| United States, Montana | |
| CCOP - Montana Cancer Consortium | |
| Billings, Montana, United States, 59101 | |
| United States, Nebraska | |
| CCOP - Missouri Valley Cancer Consortium | |
| Omaha, Nebraska, United States, 68131 | |
| Methodist Cancer Center - Omaha | |
| Omaha, Nebraska, United States, 68114 | |
| United States, Nevada | |
| CCOP - Southern Nevada Cancer Research Foundation | |
| Las Vegas, Nevada, United States, 89106 | |
| United States, New Hampshire | |
| Norris Cotton Cancer Center | |
| Lebanon, New Hampshire, United States, 03756 | |
| Elliot Regional Cancer Center | |
| Manchester, New Hampshire, United States, 03103 | |
| United States, New Jersey | |
| Veterans Affairs Medical Center - East Orange | |
| East Orange, New Jersey, United States, 07018-1095 | |
| John F. Kennedy Medical Center | |
| Edison, New Jersey, United States, 08818 | |
| Elizabeth General Medical Center - West | |
| Elizabeth, New Jersey, United States, 07201 | |
| South Jersey Hospital - Millville | |
| Millville, New Jersey, United States, 08332 | |
| Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County | |
| Mount Holly, New Jersey, United States, 08060 | |
| Community Medical Center | |
| Toms River, New Jersey, United States, 08755 | |
| St. Francis Medical Center | |
| Trenton, New Jersey, United States, 08629 | |
| United States, New Mexico | |
| Saint Joseph Medical Center | |
| Albuquerque, New Mexico, United States, 87102 | |
| United States, New York | |
| Cancer Center of Albany Medical Center | |
| Albany, New York, United States, 12208 | |
| Veterans Affairs Medical Center - Albany | |
| Albany, New York, United States, 12208 | |
| Albert Einstein Comprehensive Cancer Center | |
| Bronx, New York, United States, 10461 | |
| State University of New York Health Science Center at Brooklyn | |
| Brooklyn, New York, United States, 11203 | |
| New York Methodist Hospital | |
| Brooklyn, New York, United States, 11215-3609 | |
| Roswell Park Cancer Institute | |
| Buffalo, New York, United States, 14263-0001 | |
| CCOP - North Shore University Hospital | |
| Manhasset, New York, United States, 11030 | |
| Kaplan Cancer Center | |
| New York, New York, United States, 10016 | |
| Memorial Sloan-Kettering Cancer Center | |
| New York, New York, United States, 10021 | |
| Champlain Valley Physicians Hospital Medical Center | |
| Plattsburgh, New York, United States, 12901 | |
| Vassar Brothers Hospital | |
| Poughkeepsie, New York, United States, 12601 | |
| University of Rochester Cancer Center | |
| Rochester, New York, United States, 14642 | |
| Genesee Hospital - Rochester | |
| Rochester, New York, United States, 14607 | |
| New York Medical College | |
| Valhalla, New York, United States, 10595 | |
| United States, North Carolina | |
| Lineberger Comprehensive Cancer Center, UNC | |
| Chapel Hill, North Carolina, United States, 27599-7295 | |
| East Carolina University School of Medicine | |
| Greenville, North Carolina, United States, 27858-4354 | |
| CCOP - Southeast Cancer Control Consortium | |
| Winston-Salem, North Carolina, United States, 27104-4241 | |
| Comprehensive Cancer Center of Wake Forest University Baptist Medical Center | |
| Winston-Salem, North Carolina, United States, 27157-1082 | |
| United States, North Dakota | |
| Meritcare Roger Maris Cancer Center | |
| Fargo, North Dakota, United States, 58122 | |
| UNI-MED Medical Center | |
| Minot, North Dakota, United States, 58701 | |
| United States, Ohio | |
| Akron City Hospital | |
| Akron, Ohio, United States, 44309 | |
| Akron General Medical Center | |
| Akron, Ohio, United States, 44302 | |
| Christ Hospital | |
| Cincinnati, Ohio, United States, 45219 | |
| Ireland Cancer Center | |
| Cleveland, Ohio, United States, 44106-5065 | |
| Arthur G. James Cancer Hospital - Ohio State University | |
| Columbus, Ohio, United States, 43210 | |
| CCOP - Columbus | |
| Columbus, Ohio, United States, 43206 | |
| Veterans Affairs Medical Center - Dayton | |
| Dayton, Ohio, United States, 45428 | |
| CCOP - Dayton | |
| Kettering, Ohio, United States, 45429 | |
| CCOP - Toledo Community Hospital Oncology Program | |
| Toledo, Ohio, United States, 43623-3456 | |
| United States, Oklahoma | |
| St. John Medical Center | |
| Tulsa, Oklahoma, United States, 74104 | |
| United States, Oregon | |
| Samaritan Regional Cancer Center | |
| Corvallis, Oregon, United States, 97339 | |
| CCOP - Columbia River Program | |
| Portland, Oregon, United States, 97213 | |
| United States, Pennsylvania | |
| Penn State Geisinger Medical Center | |
| Danville, Pennsylvania, United States, 17822-2001 | |
| Mercy Catholic Medical Center, Mercy Fitzgerald Divison | |
| Darby, Pennsylvania, United States, 19023 | |
| Delaware County Memorial Hospital | |
| Drexel Hill, Pennsylvania, United States, 19026 | |
| Penn State Geisinger Cancer Center | |
| Hershey, Pennsylvania, United States, 17033 | |
| Albert Einstein Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19141 | |
| Veterans Affairs Medical Center - Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19104 | |
| University of Pennsylvania Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19104 | |
| Fox Chase Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19111 | |
| Allegheny University Hospitals- Hahnemann | |
| Philadelphia, Pennsylvania, United States, 19102-1192 | |
| Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19107 | |
| University of Pittsburgh Cancer Institute | |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| Western Pennsylvania Hospital | |
| Pittsburgh, Pennsylvania, United States, 15224 | |
| Reading Hospital and Medical Center | |
| Reading, Pennsylvania, United States, 19612-6052 | |
| Mercy Hospital Cancer Center - Scranton | |
| Scranton, Pennsylvania, United States, 18501 | |
| Grand View Hospital | |
| Sellersville, Pennsylvania, United States, 18960 | |
| Wilkes Barre General Hospital | |
| Wilkes-Barre, Pennsylvania, United States, 18764 | |
| CCOP - MainLine Health | |
| Wynnewood, Pennsylvania, United States, 19096 | |
| York Hospital | |
| York, Pennsylvania, United States, 17315 | |
| United States, South Carolina | |
| Medical University of South Carolina | |
| Charleston, South Carolina, United States, 29425-0721 | |
| CCOP - Greenville | |
| Greenville, South Carolina, United States, 29615 | |
| CCOP - Upstate Carolina | |
| Spartanburg, South Carolina, United States, 29303 | |
| United States, Tennessee | |
| Jackson-Madison County General Hospital | |
| Jackson, Tennessee, United States, 38301 | |
| Baptist Regional Cancer Center - Knoxville | |
| Knoxville, Tennessee, United States, 37901 | |
| CCOP - Baptist Cancer Institute | |
| Memphis, Tennessee, United States, 38117 | |
| University of Tennessee, Memphis Cancer Center | |
| Memphis, Tennessee, United States, 38163 | |
| Vanderbilt Cancer Center | |
| Nashville, Tennessee, United States, 37232-6838 | |
| United States, Texas | |
| Julie and Ben Rogers Cancer Institute | |
| Beaumont, Texas, United States, 77701 | |
| University of Texas Medical Branch | |
| Galveston, Texas, United States, 77555-1329 | |
| University of Texas - MD Anderson Cancer Center | |
| Houston, Texas, United States, 77030 | |
| Wilford Hall - 59th Medical Wing | |
| Lackland Air Force Base, Texas, United States, 78236-5300 | |
| Bayshore Medical Center | |
| Pasadena, Texas, United States, 77504 | |
| United States, Utah | |
| Dixie Regional Medical Center | |
| Saint George, Utah, United States, 84770 | |
| LDS Hospital | |
| Salt Lake City, Utah, United States, 84143 | |
| United States, Vermont | |
| CCOP - Southwestern Vermont Regional Cancer Center | |
| Bennington, Vermont, United States, 05201 | |
| Green Mountain Oncology Group | |
| Rutland, Vermont, United States, 05701 | |
| Veterans Affairs Medical Center - White River Junction | |
| White River Junction, Vermont, United States, 05009 | |
| United States, Virginia | |
| Martha Jefferson Hospital | |
| Charlottesville, Virginia, United States, 22901 | |
| Virginia Baptist Hospital | |
| Lynchburg, Virginia, United States, 24503 | |
| Naval Medical Center, Portsmouth | |
| Portsmouth, Virginia, United States, 23708-2197 | |
| Massey Cancer Center | |
| Richmond, Virginia, United States, 23298-0037 | |
| United States, Washington | |
| Swedish Hospital Tumor Institute | |
| Seattle, Washington, United States, 98104 | |
| Virginia Mason Medical Center | |
| Seattle, Washington, United States, 98111 | |
| Deaconess Medical Center | |
| Spokane, Washington, United States, 99210-0248 | |
| Yakima Valley Memorial Hospital | |
| Yakima, Washington, United States, 98902 | |
| United States, West Virginia | |
| Schiffler Oncology Center | |
| Wheeling, West Virginia, United States, 26003 | |
| United States, Wisconsin | |
| St. Vincent Hospital | |
| Green Bay, Wisconsin, United States, 54307-3508 | |
| Gundersen Lutheran Medical Foundation | |
| La Crosse, Wisconsin, United States, 54601 | |
| University of Wisconsin Comprehensive Cancer Center | |
| Madison, Wisconsin, United States, 53792 | |
| Southern Wisconsin Radiotherapy Center | |
| Madison, Wisconsin, United States, 53713 | |
| Veterans Affairs Medical Center - Madison | |
| Madison, Wisconsin, United States, 53705 | |
| Marshfield Clinic | |
| Marshfield, Wisconsin, United States, 54449 | |
| CCOP - Marshfield Medical Research and Education Foundation | |
| Marshfield, Wisconsin, United States, 54449 | |
| Community Memorial Hospital | |
| Menomonee Falls, Wisconsin, United States, 53051 | |
| Medical College of Wisconsin | |
| Milwaukee, Wisconsin, United States, 53226 | |
| St. Luke's Medical Center | |
| Milwaukee, Wisconsin, United States, 53215 | |
| St. Joseph's Hospital | |
| Milwaukee, Wisconsin, United States, 53210 | |
| Veterans Affairs Medical Center - Milwaukee (Zablocki) | |
| Milwaukee, Wisconsin, United States, 53295 | |
| Columbia Hospital | |
| Milwaukee, Wisconsin, United States, 53211 | |
| Southeastern Wisconsin Regional Cancer Center | |
| Racine, Wisconsin, United States, 53405 | |
| Canada, Alberta | |
| Tom Baker Cancer Center - Calgary | |
| Calgary, Alberta, Canada, T2N 4N2 | |
| Cross Cancer Institute | |
| Edmonton, Alberta, Canada, T6G 1Z2 | |
| Canada, British Columbia | |
| British Columbia Cancer Agency - Vancouver Island Cancer Centre | |
| Victoria, British Columbia, Canada, V8R 1J8 | |
| Canada, New Brunswick | |
| Doctor Leon Richard Oncology Centre | |
| Moncton, New Brunswick, Canada, E1C 8X3 | |
| Saint John Regional Hospital | |
| Saint John, New Brunswick, Canada, E2L 4L2 | |
| Canada, Nova Scotia | |
| Nova Scotia Cancer Centre | |
| Halifax, Nova Scotia, Canada, B3H 1V7 | |
| Canada, Ontario | |
| Cancer Care Ontario-Hamilton Regional Cancer Centre | |
| Hamilton, Ontario, Canada, L8V 5C2 | |
| Kingston Regional Cancer Centre | |
| Kingston, Ontario, Canada, K7L 5P9 | |
| Cancer Care Ontario-London Regional Cancer Centre | |
| London, Ontario, Canada, N6A 4L6 | |
| Ottawa Regional Cancer Centre - Civic Campus | |
| Ottawa, Ontario, Canada, K1Y 4K7 | |
| Northeastern Ontario Regional Cancer Centre, Sudbury | |
| Sudbury, Ontario, Canada, P3E 5J1 | |
| Northwestern Ontario Regional Cancer Centre, Thunder Bay | |
| Thunder Bay, Ontario, Canada, P7A 7T1 | |
| Princess Margaret Hospital | |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Canada, Quebec | |
| Centre Hospitalier de l'Universite de Montreal | |
| Montreal, Quebec, Canada, H2W-W1T8 | |
| McGill University Department of Oncology | |
| Montreal, Quebec, Canada, H2W 1S6 | |
| Canada, Saskatchewan | |
| Saskatoon Cancer Centre | |
| Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
| South Africa | |
| Pretoria Academic Hospital | |
| Pretoria, South Africa, 0001 | |
Sponsors and Collaborators
Radiation Therapy Oncology Group
Eastern Cooperative Oncology Group
Investigators
| Study Chair: | William G. Kraybill, MD, FACS | Roswell Park Cancer Institute |
| Study Chair: | Ronald H. Blum, MD | New York University School of Medicine |
More Information
Additional Information:
Publications:
Kraybill WG, Harris JH, Spiro I, et al.: Radiation Therapy Oncology Group (RTOG) 9514: a phase II study of neoadjuvant chemotherapy (CT) and radiation therapy (RT) in the management of high risk (HR), high grade, soft tissue sarcomas (STS) of the extremities and body wall. [Abstract] Proceedings of the American Society of Clinical Oncology 22: A-3276, 2003.
Kraybill WG, Spiro I, Harris J, et al.: Radiation Therapy Oncology Group (RTOG) 95-14: a phase II study of neoadjuvant chemotherapy (CT) and radiation therapy (RT) in high risk (HR), high grade, soft tissue sarcomas (STS) of the extremities and body wall: a preliminary report. [Abstract] Proceedings of the American Society of Clinical Oncology 20: A-1387, 2001.
| ClinicalTrials.gov Identifier: | NCT00002791 History of Changes |
| Other Study ID Numbers: | CDR0000064856, RTOG-9514, E-R9514, RTOG-R9514 |
| Study First Received: | November 1, 1999 |
| Last Updated: | June 25, 2010 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
|
stage II adult soft tissue sarcoma stage III adult soft tissue sarcoma recurrent adult soft tissue sarcoma |
Additional relevant MeSH terms:
|
Sarcoma Neoplasms, Connective and Soft Tissue Neoplasms by Histologic Type Neoplasms Dacarbazine Ifosfamide Isophosphamide mustard Doxorubicin Lenograstim Antineoplastic Agents, Alkylating |
Alkylating Agents Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Antineoplastic Agents Therapeutic Uses Antibiotics, Antineoplastic Adjuvants, Immunologic Immunologic Factors Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on May 16, 2013