Inclusion Criteria

Concurrent Medication:

Required:

• PCP prophylaxis if CD4 count <= 200 cells/mm3.

Allowed:

• Intralesional therapy for KS.
• Vitamins.
• Nucleoside RT inhibitors, provided regimen remains stable for first 8 weeks of study.

Concurrent Treatment:

Allowed:

• Acupuncture.
• Visualization techniques.

Patients must have:

• HIV infection.
• Prior hard capsule saquinavir at 1800 mg/day for more than 1 year.

Prior Medication:

Allowed:

• Prior saquinavir.
• Prior antiretrovirals, excluding protease inhibitors other than saquinavir.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Psychological condition or medical instability that would interfere with study evaluation or procedures.

AS PER AMENDMENT 5/7/97:

• Active tuberculosis.

Concurrent Medication:

Excluded:

• Protease inhibitors other than study drugs.
• Non-nucleoside RT inhibitors.
• Interferon.
• Interleukins.
• GM-CSF.
• HIV vaccines.
• Systemic cytotoxic chemotherapy.
• Investigational drugs other than study medications.
• Rifabutin.
• Rifampin.
• Midazolam.
• Triazolam.
• Ketoconazole.
• Delavirdine.
• Cisapride.
• Terfenadine.
• Astemizole.

AS PER AMENDMENT 5/7/97:

• Nevirapine.

Patients with the following prior conditions are excluded:

• Unexplained fever > 38.5 C for any 7 days within 30 days prior to study entry.
• Diarrhea persisting for 15 days within 30 days prior to study entry.

Prior Medication:

Excluded:

• Any prior protease inhibitor other than saquinavir.

Excluded within the past 2 months.

• Change in antiretroviral regimen.
• Systemic chemotherapy for KS.

Excluded within the past month:

• Non-nucleoside RT inhibitors.
• Interferons.
• Interleukins.
• HIV vaccines.
• Experimental therapies.

Excluded within the past 2 weeks:

• Rifabutin.
• Cisapride.
• Terfenadine.
• Astemizole.
• Midazolam.
• Triazolam.
• Oral ketoconazole.
• Delavirdine.
• Acute therapy for infection or other medical illness.

Active substance abuse that would interfere with study evaluation or procedures.