Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease

This study has been completed.

Study NCT00482573 Information provided by University of Sao Paulo

First Received: June 4, 2007 Last Updated: June 4, 2008 History of Changes

No Study Results Posted on ClinicalTrials.gov for this Study

About Study Results Reporting on ClinicalTrials.gov

Study Status:	This study has been completed.
Study Completion Date:	January 2006
Primary Completion Date:	July 2005 (Final data collection date for primary outcome measure)

Publications:

[No authors listed] ACOG practice bulletin. Antepartum fetal surveillance. Number 9, October 1999 (replaces Technical Bulletin Number 188, January 1994). Clinical management guidelines for obstetrician-gynecologists. Int J Gynaecol Obstet. 2000 Feb;68(2):175-85.

[No authors listed] Electronic fetal heart rate monitoring: research guidelines for interpretation. National Institute of Child Health and Human Development Research Planning Workshop. Am J Obstet Gynecol. 1997 Dec;177(6):1385-90. Review.

[No authors listed] Status report: the periodontal ligament injection. Council on Dental Materials, Instruments, and Equipment. J Am Dent Assoc. 1983 Feb;106(2):222-4. No abstract available.

Avila WS, Rossi EG, Ramires JA, Grinberg M, Bortolotto MR, Zugaib M, da Luz PL. Pregnancy in patients with heart disease: experience with 1,000 cases. Clin Cardiol. 2003 Mar;26(3):135-42.

Aberg G. Studies on the duration of local anesthesia: a possible mechanism for the prolonging effect of "vasoconstrictors" on the duration of infiltration anesthesia. Int J Oral Surg. 1980 Apr;9(2):144-7.

Abraham-Inpijn L, Borgmeijer-Hoelen A, Gortzak RA. Changes in blood pressure, heart rate, and electrocardiogram during dental treatment with use of local anesthesia. J Am Dent Assoc. 1988 Apr;116(4):531-6.

BADER RA, BADER ME, ROSE DF, BRAUNWALD E. Hemodynamics at rest and during exercise in normal pregnancy as studies by cardiac catheterization. J Clin Invest. 1955 Oct;34(10):1524-36. No abstract available.

Beck FM, Weaver JM 2nd. Blood pressure and heart rate responses to anticipated high-stress dental treatment. J Dent Res. 1981 Jan;60(1):26-9.

Bhatla N, Lal S, Behera G, Kriplani A, Mittal S, Agarwal N, Talwar KK. Cardiac disease in pregnancy. Int J Gynaecol Obstet. 2003 Aug;82(2):153-9.

Biehl D, Shnider SM, Levinson G, Callender K. Placental transfer of lidocaine: effects of fetal acidosis. Anesthesiology. 1978 Jun;48(6):409-12.

Blinder D, Shemesh J, Taicher S. Electrocardiographic changes in cardiac patients undergoing dental extractions under local anesthesia. J Oral Maxillofac Surg. 1996 Feb;54(2):162-5; discussion 165-6.

Blinder D, Manor Y, Shemesh J, Taicher S. Electrocardiographic changes in cardiac patients having dental extractions under a local anesthetic containing a vasopressor. J Oral Maxillofac Surg. 1998 Dec;56(12):1399-402; discussion 1402-3.

Brand HS, Gortzak RA, Abraham-Inpijn L. Anxiety and heart rate correlation prior to dental checkup. Int Dent J. 1995 Dec;45(6):347-51.

Brand HS, Gortzak RA, Palmer-Bouva CC, Abraham RE, Abraham-Inpijn L. Cardiovascular and neuroendocrine responses during acute stress induced by different types of dental treatment. Int Dent J. 1995 Feb;45(1):45-8. Review.

Braunwald E, Bloodwell RD, Goldberg LI, Morrow AG. STUDIES ON DIGITALIS. IV. OBSERVATIONS IN MAN ON THE EFFECTS OF DIGITALIS PREPARATIONS ON THE CONTRACTILITY OF THE NON-FAILING HEART AND ON TOTAL VASCULAR RESISTANCE. J Clin Invest. 1961 Jan;40(1):52-9. No abstract available.

Brooks VL, Kane CM, Van Winkle DM. Altered heart rate baroreflex during pregnancy: role of sympathetic and parasympathetic nervous systems. Am J Physiol. 1997 Sep;273(3 Pt 2):R960-6.

Buckley JA, Ciancio SG, McMullen JA. Efficacy of epinephrine concentration in local anesthesia during periodontal surgery. J Periodontol. 1984 Nov;55(11):653-7.

Cannell H, Kerawala C, Webster K, Whelpton R. Are intraligamentary injections intravascular? Br Dent J. 1993 Oct 23;175(8):281-4.

Cannell H, Walters H, Beckett AH, Saunders A. Circulating levels of lignocaine after peri-oral injections. Br Dent J. 1975 Feb 4;138(3):87-93. No abstract available.

Cioffi GA, Chernow B, Glahn RP, Terezhalmy GT, Lake CR. The hemodynamic and plasma catecholamine responses to routine restorative dental care. J Am Dent Assoc. 1985 Jul;111(1):67-70.

Clark S, Hofmeyr GJ, Coats AJ, Redman CW. Ambulatory blood pressure monitoring during pregnancy: validation of the TM-2420 monitor. Obstet Gynecol. 1991 Jan;77(1):152-5.

Corah NL. Development of a dental anxiety scale. J Dent Res. 1969 Jul-Aug;48(4):596. No abstract available.

Danzell JD. Pregnancy and pre-existing heart disease. J La State Med Soc. 1998 Feb;150(2):97-102. Review.

Davenport RE, Porcelli RJ, Iacono VJ, Bonura CF, Mallis GI, Baer PN. Effects of anesthetics containing epinephrine on catecholamine levels during periodontal surgery. J Periodontol. 1990 Sep;61(9):553-8.

Dawes GS, Moulden M, Redman CW. Criteria for the design of fetal heart rate analysis systems. Int J Biomed Comput. 1990 May;25(4):287-94.

Defosse O. [Local anesthesia with and without vasoconstrictors: indications, contra-indications and complications in relation to the health of the patient] Rev Belge Med Dent. 1999;54(4):242-58. Review. French.

Druzin ML, Fox A, Kogut E, Carlson C. The relationship of the nonstress test to gestational age. Am J Obstet Gynecol. 1985 Oct 15;153(4):386-9.

Edmondson HD, Roscoe B, Vickers MD. Biochemical evidence of anxiety in dental patients. Br Med J. 1972 Oct 7;4(5831):7-9. No abstract available.

Elkayam U, Bitar F. Valvular heart disease and pregnancy part I: native valves. J Am Coll Cardiol. 2005 Jul 19;46(2):223-30. Review.

Evertson LR, Gauthier RJ, Schifrin BS, Paul RH. Antepartum fetal heart rate testing. I. Evolution of the nonstress test. Am J Obstet Gynecol. 1979 Jan 1;133(1):29-33.

Friedman MJ, Hochman MN. A 21st century computerized injection system for local pain control. Compend Contin Educ Dent. 1997 Oct;18(10):995-1000, 1002-3; quiz 1004. Review.

Galili D, Kaufman E, Garfunkel AA, Michaeli Y. Intraligamentary anesthesia--a histological study. Int J Oral Surg. 1984 Dec;13(6):511-6.

Gauthier RJ, Evertson LR, Paul RH. Antepartum fetal heart rate testing. II. Intrapartum fetal heart rate observation and newborn outcome following a positive contraction stress test. Am J Obstet Gynecol. 1979 Jan 1;133(1):34-9.

Giuliani M, Grossi GB, Pileri M, Lajolo C, Casparrini G. Could local anesthesia while breast-feeding be harmful to infants? J Pediatr Gastroenterol Nutr. 2001 Feb;32(2):142-4.

Goldstein MA, Michelson EL, Dreifus LS. The electrocardiogram in valvular heart disease. Cardiovasc Clin. 1993;23:55-64. Review. No abstract available.

Gortzak RA, Abraham-Inpijn L. Blood pressure measurements during dental checkups representative of 26-hour registration. Oral Surg Oral Med Oral Pathol. 1990 Dec;70(6):730-3.

Gortzak RA, Abraham-Inpijn L. Pain-induced hypertensive episode in the dental office. Gen Dent. 1995 May-Jun;43(3):274-6. No abstract available.

Gortzak RA, Abraham-Inpijn L, Oosting J. Blood pressure response to dental checkup: a continuous, noninvasive registration. Gen Dent. 1991 Sep-Oct;39(5):339-42. No abstract available.

Gortzak RA, Abraham-Inpijn L, Peters G. Non-invasive 27-hour blood pressure registration including dental checkups in some dental practices. Clin Prev Dent. 1992 Sep-Oct;14(5):5-10.

Gray RJ, Lomax AM, Rood JP. Periodontal ligament injection: with or without a vasoconstrictor? Br Dent J. 1987 Apr 11;162(7):263-5. No abstract available.

Haas DA, Pynn BR, Sands TD. Drug use for the pregnant or lactating patient. Gen Dent. 2000 Jan-Feb;48(1):54-60. Review.

Hochman M, Chiarello D, Hochman CB, Lopatkin R, Pergola S. Computerized local anesthetic delivery vs. traditional syringe technique. Subjective pain response. N Y State Dent J. 1997 Aug-Sep;63(7):24-9.

Jastak JT, Yagiela JA. Vasoconstrictors and local anesthesia: a review and rationale for use. J Am Dent Assoc. 1983 Oct;107(4):623-30. Review. No abstract available.

Kim S. Ligamental injection: a physiological explanation of its efficacy. J Endod. 1986 Oct;12(10):486-91. No abstract available.

Krochak M, Friedman N. Using a precision-metered injection system to minimize dental injection anxiety. Compend Contin Educ Dent. 1998 Feb;19(2):137-40, 142-3, 146 passim; quiz 150.

Kubo SH, Schulman S, Starling RC, Jessup M, Wentworth D, Burkhoff D. Development and validation of a patient questionnaire to determine New York Heart Association classification. J Card Fail. 2004 Jun;10(3):228-35.

LUND A. Elimination of adrenaline and noradrenaline from the organism. Acta Pharmacol Toxicol (Copenh). 1951;7(4):297-308. No abstract available.

Lund CJ, Donovan JC. Blood volume during pregnancy. Significance of plasma and red cell volumes. Am J Obstet Gynecol. 1967 Jun 1;98(3):394-403. No abstract available.

Malamed SF. The periodontal ligament (PDL) injection: an alternative to inferior alveolar nerve block. Oral Surg Oral Med Oral Pathol. 1982 Feb;53(2):117-21.

Mancia G, Bertinieri G, Grassi G, Parati G, Pomidossi G, Ferrari A, Gregorini L, Zanchetti A. Effects of blood-pressure measurement by the doctor on patient's blood pressure and heart rate. Lancet. 1983 Sep 24;2(8352):695-8.

Mauri L, O'Gara PT. Valvular Heart Disease in the Pregnant Patient. . 2001 Feb;3(1):7-14.

Meechan JG. Intraligamentary anaesthesia. J Dent. 1992 Dec;20(6):325-32. Review.

Meyer FU. Haemodynamic changes under emotional stress following a minor surgical procedure under local anaesthesia. Int J Oral Maxillofac Surg. 1987 Dec;16(6):688-94.

Meyer FU. Hemodynamic changes of local dental anesthesia in normotensive and hypertensive subjects. Int J Clin Pharmacol Ther Toxicol. 1986 Sep;24(9):477-81.

Moore PA. Selecting drugs for the pregnant dental patient. J Am Dent Assoc. 1998 Sep;129(9):1281-6. Review.

Morishima HO, Heymann MA, Rudolph AM, Barrett CT, James LS. Transfer of lidocaine across the sheep placenta to the fetus. Hemodynamic and acid-base responses of the fetal lamb. Am J Obstet Gynecol. 1975 Jul 1;122(5):581-8.

Mount GJ. A new classification and techniques for simple restorative dentistry. Ann R Australas Coll Dent Surg. 1998 Oct;14:94-8. Review.

Mount GJ, Hume WR. A new cavity classification. Aust Dent J. 1998 Jun;43(3):153-9.

Mount GJ, Hume WR. A revised classification of carious lesions by site and size. Quintessence Int. 1997 May;28(5):301-3.

Naftalin LW, Yagiela JA. Vasoconstrictors: indications and precautions. Dent Clin North Am. 2002 Oct;46(4):733-46, ix. Review.

Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol. 2006 May;107(5):1120-38. Review.

Naidoo DP, Desai DK, Moodley J. Maternal deaths due to pre-existing cardiac disease. Cardiovasc J S Afr. 2002 Jan-Feb;13(1):17-20. Review.

Nakamura Y, Matsumura K, Miura K, Kurokawa H, Abe I, Takata Y. Cardiovascular and sympathetic responses to dental surgery with local anesthesia. Hypertens Res. 2001 May;24(3):209-14.

Nusstein J, Claffey E, Reader A, Beck M, Weaver J. Anesthetic effectiveness of the supplemental intraligamentary injection, administered with a computer-controlled local anesthetic delivery system, in patients with irreversible pulpitis. J Endod. 2005 May;31(5):354-8.

Palatini P, Frigo G, Bertolo O, Roman E, Da Corta R, Winnicki M. Validation of the A&D TM-2430 device for ambulatory blood pressure monitoring and evaluation of performance according to subjects' characteristics. . 1998 Aug;3(4):255-260.

Partyka W, Pajszczyk-Kieszkiewicz T, Januszewicz-Witorzenc J, Swatko-Piotrowska K. [Effect of oral surgery on the fetus and uterus in complicated pregnancy] Pol Tyg Lek. 1977 Aug 8;32(32):1245-7. Polish. No abstract available.

Robson SC, Hunter S, Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol. 1989 Apr;256(4 Pt 2):H1060-5.

Rosner B. Fundamentals of biostatistics. 2nd ed. Boston: PWS Publishers; 1986. p. 584.

SHIP II. The response of systolic and diastolic blood pressures to dental stress. Oral Surg Oral Med Oral Pathol. 1960 Apr;13:499-507. No abstract available.

Silberman SL, Cohen LA, Meydrech EF. Dental anxiety and needs in low-income pregnant women. Community Dent Oral Epidemiol. 1980 Apr;8(2):114-5.

Siu SC, Sermer M, Harrison DA, Grigoriadis E, Liu G, Sorensen S, Smallhorn JF, Farine D, Amankwah KS, Spears JC, Colman JM. Risk and predictors for pregnancy-related complications in women with heart disease. Circulation. 1997 Nov 4;96(9):2789-94.

Silversides CK, Colman JM, Sermer M, Siu SC. Cardiac risk in pregnant women with rheumatic mitral stenosis. Am J Cardiol. 2003 Jun 1;91(11):1382-5. No abstract available.

Smith JH, Dawes GS, Redman CW. Low human fetal heart rate variation in normal pregnancy. Br J Obstet Gynaecol. 1987 Jul;94(7):656-64.

Szekely P, Turner R, Snaith L. Pregnancy and the changing pattern of rheumatic heart disease. Br Heart J. 1973 Dec;35(12):1293-303. No abstract available.

Thornburg KL, Jacobson SL, Giraud GD, Morton MJ. Hemodynamic changes in pregnancy. Semin Perinatol. 2000 Feb;24(1):11-4. Review.

Trierweiler MW, Freeman RK, James J. Baseline fetal heart rate characteristics as an indicator of fetal status during the antepartum period. Am J Obstet Gynecol. 1976 Jul 1;125(5):618-23.

Ueland K, Metcalfe J. Circulatory changes in pregnancy. Clin Obstet Gynecol. 1975 Sep;18(3):41-50. No abstract available.

van Mook WN, Peeters L. Severe cardiac disease in pregnancy, part I: hemodynamic changes and complaints during pregnancy, and general management of cardiac disease in pregnancy. Curr Opin Crit Care. 2005 Oct;11(5):430-4. Review.

van Mook WN, Peeters L. Severe cardiac disease in pregnancy, part II: impact of congenital and acquired cardiac diseases during pregnancy. Curr Opin Crit Care. 2005 Oct;11(5):435-48. Review.

Villablanca AC. Heart disease during pregnancy. Which cardiovascular changes are normal or transient? Postgrad Med. 1998 Oct;104(4):183-4, 187-92. Review.

Villablanca AC. Heart disease during pregnancy. Which cardiovascular changes reflect disease? Postgrad Med. 1998 Nov;104(5):149-56. Review.

Vonesh EF, Schork MA. Sample sizes in the multivariate analysis of repeated measurements. Biometrics. 1986 Sep;42(3):601-10.

Walton RE, Abbott BJ. Periodontal ligament injection: a clinical evaluation. J Am Dent Assoc. 1981 Oct;103(4):571-5.

Wood M, Reader A, Nusstein J, Beck M, Padgett D, Weaver J. Comparison of intraosseous and infiltration injections for venous lidocaine blood concentrations and heart rate changes after injection of 2% lidocaine with 1:100,000 epinephrine. J Endod. 2005 Jun;31(6):435-8.

Yagiela JA. Intravascular lidocaine toxicity: influence of epinephrine and route of administration. Anesth Prog. 1985 Mar-Apr;32(2):57-61. No abstract available.

Yagiela JA, Duffin SR, Hunt LM. Drug interactions and vasoconstrictors used in local anesthetic solutions. Oral Surg Oral Med Oral Pathol. 1985 Jun;59(6):565-71.