Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy (EDIEMHYPER)

• Score of the Achenbach Child Behavior Checklist [ Time Frame: within the first 30 days after inclusion of the patient ] [ Designated as safety issue: No ]
• Score of the conners scale [ Time Frame: within the first 30 days after inclusion of the patient ] [ Designated as safety issue: No ]
• Score of the Wechsler Intelligence Scale for Children (WISC-IV) [ Time Frame: within the first 30 days after inclusion of the patient ] [ Designated as safety issue: No ]

1. MAIN OBJECTIVE :

   To assess the consequences of a maternal hyperthyroïd during pregnancy on intellectual development of the child from 6 to 9 years

2. SECONDARY OBJECTIVES :

   1. To assess the consequences of a maternal hyperthyroïd during pregnancy on the capacities of attention, learning process and the degree of hyperactivity of the child from 6 to 9 years.

   2. To study if it exist differences of intellectual development, capacities of attention, learning process, and degree of hyperactivity in the child from 6 to 9 years, born to hyperthyroid mother during pregnancy, according to:

      • the etiology of the maternal hyperthyroïd (transitory gestation hyperthyroid versus disease of Basedow),
      • the use or not of a anti-thyroid treatment,
      • the rate of TSH néonatal (measured with the blotter by tracking with J3 at all the new born ones).

1. INCLUSION CRITERIA :

   A-For the child born to hyperthyroid mother during pregnancy :

   • Old from 6 to 9 years included
   • Age of gestation between ≥37 and <41 weeks of amenorrhoea
   • Born from a mono-foetale pregnancy
   • Euthyroïd at the time of the entry in the study
   • Provided education for at the elementary school on a level adapted to its age

   B-For hyperthyroid mother during pregnancy :

   • Hyperthyroïd during pregnancy (transitory gestation hyperthyroid or disease of Basedow)
   • Euthyroïd at the time of the entry in the study

   C-For the child born to euthyroid mother during pregnancy :

   • Old from 6 to 9 years included
   • Age of gestation between ≥37 and <41 weeks of amenorrhoea
   • Born from a mono-foetale pregnancy
   • Euthyroïd at the time of the entry in the study
   • Provided education for at the elementary school on a level adapted to its age

   D-For euthyroid mother during pregnancy :

   Euthyroïd at the time of the entry in the study

2. NON INCLUSION CRITERIA :

   A-For the child born to hyperthyroid mother during pregnancy :

   • Presenting a congenital hypothyroïd or a known thyroid dysfonction at the time of the entry in the study
   • Carrier of a chronic pathology (organic or psychological) or malformative severe
   • Presenting an antecedent of Deficit of the Attention-Hyperactivity to the 1st degree

   B-For hyperthyroid mother during pregnancy :

   • Pathological pregnancy (gravidic arterial hypertension, gravidic toxaemia, pre-eclampsia, gestational diabetes, threat of premature birth requiring hospitalization) apart from the transitory gestation hyperthyroid
   • Having presented a drug-addiction or an alcoholism during pregnancy

   C-For the child born to euthyroid mother during pregnancy :

   • Presenting a congenital hypothyroïd or a known thyroid dysfonction at the time of the entry in the study
   • Carrier of a chronic pathology (organic or psychological) or malformative severe
   • Presenting an antecedent of Deficit of the Attention-Hyperactivity to the 1st degree

   D-For euthyroid mother during pregnancy:

   • Pathological pregnancy (gravidic arterial hypertension, gravidic toxaemia, pre-eclampsia, diabetes gestationnel, threat of premature birth requiring a hospitalization) and transitory gestation hyperthyroid
   • Having presented a drug-addiction or an alcoholism during pregnancy
   • Having presented signs of thyroid dysfunction lasting pregnancy (according to the standardized questionnaire)

3. EXCLUSION CRITERIA :

   A-For the child born to hyperthyroid mother during pregnancy :

   Discovered of a thyroid dysfonction at the time of the entry in the study

   B-For hyperthyroid mother during pregnancy:

   Discovered of a thyroid dysfonction at the time of the entry in the study

   C-For the child born to euthyroid mother during pregnancy:

   Discovered of a thyroid dysfonction at the time of the entry in the study

   D-For euthyroid mother during pregnancy:

   • Discovered of a thyroid dysfonction at the time of the entry in the study
   • Carrying anti-TPO antibody at the time of the entry in the study
4. STRATEGIES / PROCEDURES :

Multicentric, comparative study of a troop of child born to hyperthyroïd mothers during pregnancy (children exposed to the maternal hyperthyroïd) and children born to euthyroïd mothers during pregnancy (nonexposed children with the maternal hyperthyroïd).

• 1st part of the study: Retrospective analyze of the files of symptomatic hyperthyroid mothers during pregnancy.
• 2nd part of the study: Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years. The exposed children (born to hyperthyroïd mothers during pregnancy) will be compared with nonexposed children (born to euthyroïd mothers during pregnancy).

• child born to hyperthyroid mother during pregnancy
  Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years.
  Intervention: Behavioral: Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years.
• child born to euthyroid mother during pregnancy
  Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years.
  Intervention: Behavioral: Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years.

1. Inclusion Criteria:

   A-For the child born to hyperthyroid mother during pregnancy :

   oOld from 6 to 9 years included oAge of gestation between ≥37 and <41 weeks of amenorrhoea oBorn from a mono-foetale pregnancy oEuthyroïd at the time of the entry in the study oProvided education for at the elementary school on a level adapted to its age

   B-For hyperthyroid mother during pregnancy :

   oHyperthyroïd during pregnancy (transitory gestation hyperthyroid or disease of Basedow) oEuthyroïd at the time of the entry in the study

   C-For the child born to euthyroid mother during pregnancy :

   oOld from 6 to 9 years included oAge of gestation between ≥37 and <41 weeks of amenorrhoea oBorn from a mono-foetale pregnancy oEuthyroïd at the time of the entry in the study oProvided education for at the elementary school on a level adapted to its age

   D-For euthyroid mother during pregnancy :

   Euthyroïd at the time of the entry in the study

2. Exclusion Criteria:

A-For the child born to hyperthyroid mother during pregnancy :

Discovered of a thyroid dysfonction at the time of the entry in the study

B-For hyperthyroid mother during pregnancy:

Discovered of a thyroid dysfonction at the time of the entry in the study

C-For the child born to euthyroid mother during pregnancy:

Discovered of a thyroid dysfonction at the time of the entry in the study

D-For euthyroid mother during pregnancy:

oDiscovered of a thyroid dysfonction at the time of the entry in the study oCarrying anti-TPO antibody at the time of the entry in the study