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Effect of High-calcium Intake on Substrate Metabolism During Exercise

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Javier Gonzalez, Northumbria University
ClinicalTrials.gov Identifier:
NCT01779245
First received: January 28, 2013
Last updated: September 4, 2013
Last verified: September 2013

January 28, 2013
September 4, 2013
October 2012
February 2013   (final data collection date for primary outcome measure)
Substrate metabolism [ Time Frame: 60 s samples every 3 min for 15 min ] [ Designated as safety issue: No ]
Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.
Same as current
Complete list of historical versions of study NCT01779245 on ClinicalTrials.gov Archive Site
  • Plasma non-esterified fatty acid concentrations [ Time Frame: Every 3 min for 15 min ] [ Designated as safety issue: No ]
    Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.
  • Plasma glycerol concentrations [ Time Frame: Every 3 min for 15 min ] [ Designated as safety issue: No ]
    Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.
Same as current
  • Serum parathyroid hormone concentration [ Time Frame: Baseline (Pre-post 2 week supplementation) ] [ Designated as safety issue: No ]
    Parathyroid hormone concentrations will be determined at rest before and after supplementation periods as a indicator of calcium status.
  • Plasma glucose-dependent insulinotropic peptide concentration [ Time Frame: Baseline (Pre-post 2 week supplementation) ] [ Designated as safety issue: No ]
    Glucose-dependent insulinotropic peptide concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.
  • Plasma glucagon-like peptide-1 concentration [ Time Frame: Baseline (Pre-post 2 week supplementation) ] [ Designated as safety issue: No ]
    Glucagon-like peptide-1 concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.
Same as current
 
Effect of High-calcium Intake on Substrate Metabolism During Exercise
The Impact of a Calcium Supplementation on Lipid Metabolism During Exercise.

A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Lipid Metabolism
  • Dietary Supplement: Calcium
    Milk-extracted calcium supplement will be used to modulate the calcium content of the milkshakes used.
  • Dietary Supplement: Placebo
  • Placebo Comparator: Control
    A chocolate milkshake with a normal calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 400 mg calcium per serving).
    Intervention: Dietary Supplement: Placebo
  • Experimental: High-Calcium
    A chocolate milkshake with a high calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 1400 mg calcium per serving).
    Intervention: Dietary Supplement: Calcium
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
13
February 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Physically active (moderate-vigorous exercise >3 time per week)
  • Male
  • 18-40 yrs of age

Exclusion Criteria:

  • Smoker
  • Known Food Allergies
  • Metabolic disorders
Male
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT01779245
32AN3
No
Javier Gonzalez, Northumbria University
Northumbria University
Not Provided
Principal Investigator: Emma J Stevenson, PhD Northumbria University
Northumbria University
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP