Beetroot Enriched Bread, Blood Pressure and Vascular Function

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Julie Lovegrove, University of Reading
ClinicalTrials.gov Identifier:
NCT01706718
First received: September 27, 2012
Last updated: October 12, 2012
Last verified: October 2012

September 27, 2012
October 12, 2012
June 2010
October 2010   (final data collection date for primary outcome measure)
Vascular reactivity [ Time Frame: Change from baseline at 2, 4 and 6 hours after bread consumption ] [ Designated as safety issue: No ]
Forearm blood flow by Laser Doppler Imaging with iontophoresis
Same as current
Complete list of historical versions of study NCT01706718 on ClinicalTrials.gov Archive Site
  • Arterial stiffness [ Time Frame: Change from baseline at 2, 4 and 6 hours after bread consumption ] [ Designated as safety issue: No ]
    Pulse wave analysis (PWA) and velocity (PWV)
  • Blood pressure [ Time Frame: Change from baseline at 30 minute intervals for 7 hours ] [ Designated as safety issue: No ]
    By ambulatory blood pressure monitor
  • Plasma nitrate [ Time Frame: Every 30 minutes for 7 hours ] [ Designated as safety issue: No ]
  • Plasma nitrite [ Time Frame: Every 30 minutes for 7 hours ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Beetroot Enriched Bread, Blood Pressure and Vascular Function
The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men

Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
Hypertension
Dietary Supplement: Bread
  • Placebo Comparator: Control white bread
    Intervention: Dietary Supplement: Bread
  • Experimental: Beetroot bread
    Intervention: Dietary Supplement: Bread

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
24
October 2010
October 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male
  • A signed consent form
  • Age 18-64 years
  • Body mass index - 18.5-30 kg/m2
  • Non-smoking, healthy individuals
  • Normal blood pressure at screening (< 150/90)

Exclusion Criteria:

  • Subjects with anaemia
  • Sufferers of chronic illnesses
  • Individuals with food allergies
  • People with diabetes
  • People with coeliac disease
  • Women
  • Vegetarians
Male
18 Years to 64 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT01706718
10/18, University of Reading
Yes
Julie Lovegrove, University of Reading
University of Reading
Not Provided
Not Provided
University of Reading
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP