Synaptic Plasticity Imaging With Diffusion MRI

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2012 by Institut National de la Santé Et de la Recherche Médicale, France.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier:
NCT01686516
First received: September 7, 2012
Last updated: September 17, 2012
Last verified: September 2012

September 7, 2012
September 17, 2012
June 2011
December 2012   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01686516 on ClinicalTrials.gov Archive Site
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Synaptic Plasticity Imaging With Diffusion MRI
Methodological Study of Synaptic Plasticity Imaging With Diffusion MRI

Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique. The researchers investigated these rapid synaptic plasticity changes with visual activation followed by BOLD and diffusion functional MRI as well as anatomical (venography, tractography by diffusion) features in young and aged subjects.

This study is devoted to explore brain plasticity by 2 modes of diffusion weighted imaging (DWI) of the brain :

  • functional imaging using DWI and BOLD
  • anatomical studies using DWI Theses DWI exams use high b-factor to sample tissue microstructure/metabolism. To correlated these DWI changes with anatomical ones, we used anatomical imaging like T1 maps and susceptibility-based maps.

First, the relatively new technique of diffusion functional magnetic Resonance (DfMRI) was explored to obtain activation of brain following visual stimulations. These modality was compared to BOLD and anatomical venography.

The DWI exams for anatomical (tractography) used both high angular resolution directional diffusion encoding (18 directions) and high b-values (as high as b=12 000 s/mm²) to obtain precise knowledge about tissue microstructure.

Study was approved by the National French Institute of Health and by french organism for biomedical studies (AFFSAPS). Study involve 35 subjects, with 5 additional subjects for eventual rejection because of ineligibility criterion, and compare 15 young (20-30 years) to aged healthy people (60-80 years).

Then, anatomical studies are devoted to obtain microstructures information about brain areas that are changed with age, and to validate fully the feasibility of the DfMRI approach.

Observational
Observational Model: Case-Crossover
Time Perspective: Retrospective
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Probability Sample

population free of any psychological or organic troubles, with no metal inclusions for MRI convenience.

"Brain Aging"
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
35
December 2012
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • ages 20-30 years
  • 60-80 years

Exclusion Criteria:

  • psychological or organic trouble
Male
20 Years to 80 Years
Yes
Contact: Renaud NICOLAS, PhD (+33)7 77 05 76 75 rnd.nicolas@gmail.com
France
 
NCT01686516
C10-58, 2011-A00034-37
No
Institut National de la Santé Et de la Recherche Médicale, France
Institut National de la Santé Et de la Recherche Médicale, France
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Not Provided
Institut National de la Santé Et de la Recherche Médicale, France
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP