Grass Sensitisation and Allergic Rhinitis in Thai Patients

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2013 by Mahidol University
Sponsor:
Collaborator:
National Research Council of Thailand
Information provided by (Responsible Party):
Punchama Pacharn, Mahidol University
ClinicalTrials.gov Identifier:
NCT01686022
First received: September 12, 2012
Last updated: April 27, 2013
Last verified: April 2013

September 12, 2012
April 27, 2013
October 2012
November 2013   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01686022 on ClinicalTrials.gov Archive Site
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Grass Sensitisation and Allergic Rhinitis in Thai Patients
The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients

Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Observational
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Retention:   Samples Without DNA
Description:

Serum

Non-Probability Sample

Allergy Clinic

  • Allergy to Grass Pollen
  • Allergic Rhinitis Due to Weed Pollens
Other: Immunoblot
serum specific IgE binds to grass extract by immunoblot
Pollen Allergy
Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition
Intervention: Other: Immunoblot
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
185
March 2014
November 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Allergic rhinitis patients age 10-50 years old
  • Control: healthy volunteer age 18-50 years old

Exclusion Criteria:

  • Chronic illness such as cardiovascular diseases, liver diseases
  • History of anaphylaxis
  • Pregnancy
Both
10 Years to 50 Years
Yes
Contact: Punchama Pacharn, MD 6624197000 ext 5670 punchama@gmail.com
Contact: Chaweewan Bunnag, MD 6624197000 ext 8040 sicbg@mahidol.ac.th
Thailand
 
NCT01686022
NRCT_G04
No
Punchama Pacharn, Mahidol University
Mahidol University
National Research Council of Thailand
Principal Investigator: Punchama Pacharn, MD Mahidol University
Mahidol University
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP