Pressure Dependent Tracheal Obstruction in Copd Patients (PDTO)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
LHL Helse
ClinicalTrials.gov Identifier:
NCT01679808
First received: September 3, 2012
Last updated: NA
Last verified: September 2012
History: No changes posted

September 3, 2012
September 3, 2012
August 2004
August 2006   (final data collection date for primary outcome measure)
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No Changes Posted
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Pressure Dependent Tracheal Obstruction in Copd Patients
Pressure Dependent Tracheal Obstruction in Copd Patients

Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study. A garden hose was compressed from one side to simulate the posterior wall of the trachea bulging into the lumen. For two obstruction lengths - 3 cm and 12 cm, the hose was increasingly compressed in eight steps. Resistance was measured at each step for airflows 1 l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a computer to estimate the cross sectional area reduction and the corresponding distance between the bulging (posterior)and the opposite (anterior) wall (AP-distance).

Patient study. 104 stable COPD patients studied by pulmonary function tests and bronchoscopy. The tracheal obstruction was observed during forced expiration and cough, and the cross sectional area reduction was estimated using the results from the model study.

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Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
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Non-Probability Sample

Patients (both sexes) in a pulmonary rehabilitation clinic

Tracheobronchomalacia
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
104
August 2011
August 2006   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • copd

Exclusion Criteria:

  • clinical evidence of malignant disease
  • not able to be subjected to bronchoscopy
Both
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No
Contact information is only displayed when the study is recruiting subjects
Norway
 
NCT01679808
GK-18, s-04058c
Yes
LHL Helse
LHL Helse
Not Provided
Principal Investigator: Ivar Ellingsen, Dr med LHL Helse
LHL Helse
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP