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Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Yongseon Choi, Yonsei University
ClinicalTrials.gov Identifier:
NCT01652612
First received: December 20, 2011
Last updated: July 3, 2013
Last verified: July 2013

December 20, 2011
July 3, 2013
August 2011
February 2013   (final data collection date for primary outcome measure)
PaO2, number of patients with hypoxia (PaO2< 90mmHg) [ Time Frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours ] [ Designated as safety issue: Yes ]
blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV
Same as current
Complete list of historical versions of study NCT01652612 on ClinicalTrials.gov Archive Site
intrapulmonary shunt [ Time Frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours ] [ Designated as safety issue: No ]
blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV
Same as current
Not Provided
Not Provided
 
Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation
Effects of Positive End-expiratory Pressure and Alveolar Recruitment on the Oxygenation and Respiratory Mechanics During One-lung Ventilation in the Supine Position

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver)
Primary Purpose: Prevention
One Lung Ventilation
Other: PEEP
8 cmH2O PEEP throughout the period of OLV and 2nd TLV
  • No Intervention: Control
    zero PEEP
  • Experimental: OLV strategy: PEEP
    1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery
    Intervention: Other: PEEP
  • Experimental: OLV strategy: PEEP followed by AR
    1. alveolar recruitment strategy before one lung ventilation
    2. 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery
    Intervention: Other: PEEP
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
99
February 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • ASA I-II
  • age: 20-75 years

Exclusion Criteria:

  • moderate to severe impaired respiratory function,
  • heart failure,
  • patients' refusal
Both
20 Years to 75 Years
No
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT01652612
4-2011-0301
Yes
Yongseon Choi, Yonsei University
Yonsei University
Not Provided
Principal Investigator: Yongseon Choi Assistant professor
Yonsei University
July 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP