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Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression (IGEDEPP)

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2013 by Assistance Publique - Hôpitaux de Paris
Sponsor:
Information provided by (Responsible Party):
Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:
NCT01648816
First received: July 20, 2012
Last updated: September 2, 2013
Last verified: August 2013

July 20, 2012
September 2, 2013
November 2011
November 2014   (final data collection date for primary outcome measure)
Depressed subject at Week 8 and at 1 year (EPDS and DSM I-V criteria for depression [ Time Frame: 8 weeks-1 year ] [ Designated as safety issue: Yes ]
Depressed subject at Week 8 (EPDS and DSM I-V criteria for depression [ Time Frame: 8 weeks ] [ Designated as safety issue: Yes ]
Complete list of historical versions of study NCT01648816 on ClinicalTrials.gov Archive Site
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Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression
Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression

"The prevalence of postpartum depression (PPD) is approximately 13%. PPD is associated with a higher maternal morbidity and mortality, and also with pervasive effects on the emotional, cognitive and behavioral development of the infant.

Stressful life events, socio-demographic and obstetrical risk factors have been associated with the risk of PPD. Genetics risk factors of PPD have also been identified. We are presently studying for the first time how maternal stressors may interact with genetic factors to increase the risk of PPD (Gene x Environment interaction)".

"The prevalence of postpartum depression (PPD) is approximately 13%. PPD is associated with a higher maternal morbidity and mortality, and also with pervasive effects on the emotional, cognitive and behavioral development of the infant.

Stressful life events, socio-demographic and obstetrical risk factors have been associated with the risk of PPD. Genetics risk factors of PPD have also been identified. We are presently studying for the first time how maternal stressors may interact with genetic factors to increase the risk of PPD (Gene x Environment interaction).

We want first to analyze the allelic association between SNPs of 5-HT, HPA and neurodevelopment genes and PPD with a case control association study We then analyse the interaction between maternal stressors during pregnancy and SNPS of our candidate genes (CRHR1, 5-HTT, TPH, BDNF, HMCN1).

3000 Caucasian mothers are included after pregnancy in 7 maternities and are evaluated at the inclusion, at 8 weeks and at 1 year with DIGS, FISC, EPDS and HAD, Stressful life events (Paykel). Blood are collected for all subjects for DNA extraction.

At week 8 and 1 year after pregnancy we search PPD with EDPS and DSM-IV criteria of depression".

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

causasian mothers after pregnancy

Postpartum Depression
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  • postpartum depression
    caucasian mothers with postpartum depression
  • Postpartum depression
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
3000
November 2014
November 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Caucasian mothers included after pregnancy (J0-J4)

Exclusion Criteria:

  • Age <18 years old, schizophrenia or mental retardation
Female
18 Years to 60 Years
Yes
Contact: Caroline Dubertret, MD, PhD 00331 47 60 64 13 caroline.dubertret@lmr.aphp.fr
France
 
NCT01648816
AOM 10056, 2010-A01315-35
Yes
Assistance Publique - Hôpitaux de Paris
Assistance Publique - Hôpitaux de Paris
Not Provided
Study Director: Caroline Dubertret, MD, PhD Assistance Publique - Hôpitaux de Paris
Assistance Publique - Hôpitaux de Paris
August 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP