Social Interactions: Ocular Explorations and Pupillometry in Autism (ISEOP)

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by Institut National de la Santé Et de la Recherche Médicale, France
Sponsor:
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier:
NCT01647295
First received: July 19, 2012
Last updated: March 3, 2014
Last verified: March 2014

July 19, 2012
March 3, 2014
February 2013
May 2015   (final data collection date for primary outcome measure)
Total time spent on pictures [ Time Frame: two years ] [ Designated as safety issue: No ]
Total time tracked during exploration of faces and human motion, compared to objects
Same as current
Complete list of historical versions of study NCT01647295 on ClinicalTrials.gov Archive Site
Interest zones [ Time Frame: two years ] [ Designated as safety issue: No ]
Time spent on interest zones such as eyes or mouth.
Same as current
Not Provided
Not Provided
 
Social Interactions: Ocular Explorations and Pupillometry in Autism
Social Interactions: Ocular Explorations and Pupillometry in Autism

The primary objective of this work will first to characterize in typical childhood, visual exploratory behavior and pupillary response associated with salience of human social stimuli (faces and body movements), and then to evaluate these markers in children with autism.

The second objective of this work will be to achieve in a population of children with autism a longitudinal evaluation of these markers during development and therapeutics.

Patients with autism have significant social difficulties and communication alterations. It has been shown in these patients difficulties to understand some clues indispensable to social relations, for example, faces and their emotions and motion of human bodies. The faces and human movements are an important source of information helping to interact with others. Understanding the intentions of the others through facial expressions and gestures can help them to adapt their behavior and their interactions. While in healthy subjects, faces and human movements receive special attention, autistic patients seem to pay less attention to this kind of social stimuli. It has already been shown that children and healthy adults spend more time looking at faces and human movements (relative to objects), whereas the opposite behavior is observed in patients with autism. Studying gaze behavior seems to be essential for progress in the understanding of autism pathology. Eye-tracking systems allow to measure precisely what a subject looks on a picture. Moreover, eye-tracking systems permit the measurement of the pupil size which variations are correlated with cognitive processes. The objective of this study is to analyze the ocular behavior (ocular scan path and pupil diameter) of young patients with autism when viewing faces and human movements and to compare these measurements with those of chronologically age-matched healthy children. This work will identify attentional problems concerning exploration of human faces and movements that can be related to their social difficulties. These disorders should be manifested by an atypical ocular scan path and by changes in pupil variation in response to face and human motion. Then to follow the evolution of these indices will allow to evaluate the effect of therapies. These results will highlight new data essential to understanding disorders of social relations and to better adapt rehabilitative strategies.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Autistic children from the University Hospital of Tours Healthy children from the normal population

Autism Spectrum Disorders
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
150
May 2015
May 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • For autistic children, diagnosis of autism spectrum disorders according to DSM IV-TR and ADI / ADOS criteria ; normal or corrected vision; no nervous system disease
  • For healthy children, normal schooling and normal or corrected vision
  • For all, parental consents

Exclusion Criteria:

  • psychotropic treatment
Both
3 Years to 12 Years
Yes
Contact: Frederique Bonnet-Brilhault, PU-PH 0247478412 f.bonnet-brilhault@chu-tours.fr
France
 
NCT01647295
C11-60, 2012-A00520-43
No
Institut National de la Santé Et de la Recherche Médicale, France
Institut National de la Santé Et de la Recherche Médicale, France
Not Provided
Not Provided
Institut National de la Santé Et de la Recherche Médicale, France
March 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP