LEft Atrial Pacing in Diastolic Heart Failure (LEAD)

This study is currently recruiting participants.
Verified January 2014 by Centre Hospitalier Universitaire Dijon
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire Dijon
ClinicalTrials.gov Identifier:
NCT01618981
First received: June 7, 2012
Last updated: January 6, 2014
Last verified: January 2014

June 7, 2012
January 6, 2014
September 2012
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Complete list of historical versions of study NCT01618981 on ClinicalTrials.gov Archive Site
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LEft Atrial Pacing in Diastolic Heart Failure
LEft Atrial Pacing in Diastolic Heart Failure

The purpose of this study is to assess left atrial pacing therapy in patients with atrial dyssynchrony syndrome and heart failure with preserved ejection fraction.

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Interventional
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  • Heart Failure With Preserved Ejection Fraction
  • Atrial Dyssynchrony Syndrome
  • Left Atrio-ventricular Asynchrony
Procedure: pace make active/inactive cross over
  • Experimental: first active
    Intervention: Procedure: pace make active/inactive cross over
  • Experimental: first inactive
    Intervention: Procedure: pace make active/inactive cross over
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
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Inclusion Criteria:

  • Age ≥ 65
  • Sinus rhythm, PR < 220ms, QRS < 110ms
  • Heart failure (NYHA class III-IV or II with hospitalization for heart failure)
  • Ejection Fraction > 50%, restrictive mitral inflow, Lateral E/e' > 12 or septal E/e' > 15, Left atrial index volume > 34 ml/m²
  • Atrial dyssynchrony syndrome: (TTE) inter-atrial time delay ≥ 70ms (difference between tricuspid and mitral P-A intervals or between mitral and tricupsid P-A' intervals with DTI)
  • Left atrio-ventricular asynchrony: Time Difference between tricupsid and mitral A wave duration ≥ 35ms.
Both
65 Years and older
No
Contact: Gabriel LAURENT 01133 380293536 gabriel.laurent@chu-dijon.fr
Contact: Jean Christophe EICHER 01133 380293313 jean-christophe.eicher@chu-dijon.fr
France
 
NCT01618981
LAURENT PHRC N 2011
Yes
Centre Hospitalier Universitaire Dijon
Centre Hospitalier Universitaire Dijon
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Centre Hospitalier Universitaire Dijon
January 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP