Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2013 by Charite University, Berlin, Germany
Sponsor:
Information provided by (Responsible Party):
Jonathan List, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier:
NCT01593956
First received: May 7, 2012
Last updated: May 22, 2013
Last verified: May 2013

May 7, 2012
May 22, 2013
March 2012
July 2013   (final data collection date for primary outcome measure)
Improvement of cortical plasticity after anodal tDCS in concussed athletes
Same as current
Complete list of historical versions of study NCT01593956 on ClinicalTrials.gov Archive Site
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Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes
Influence of Anodal Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes and Healthy Volunteers

Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced. This is possibly due to an increased GABAergic activity, what have been found in concussed athletes by paired pulse protocols in TMS.

GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS.

Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.

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Interventional
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Endpoint Classification: Efficacy Study
Primary Purpose: Treatment
  • Concussed Athletes
  • Healthy Controls
Behavioral: tDCS
  • Concussed athletes
    Intervention: Behavioral: tDCS
  • Healthy controls
    Intervention: Behavioral: tDCS

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
30
Not Provided
July 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • history of at least 2 sports concussion
  • age 18 - 50 years

Exclusion Criteria:

  • structural deficit on cerebral MRI
  • Epilepsy
  • neurological disorder
  • intake of CNS-active drugs
Both
18 Years to 50 Years
Yes
Germany
 
NCT01593956
EA1/021/12
No
Jonathan List, Charite University, Berlin, Germany
Charite University, Berlin, Germany
Not Provided
Principal Investigator: Jonathan List, MD Charité - Department of Neurology
Principal Investigator: Agnes Flöel, Prof. Charité - Department of Neurology
Charite University, Berlin, Germany
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP