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Obstructive Sleep Apnea in Pulmonary Embolism

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
meral uyar, University of Gaziantep
ClinicalTrials.gov Identifier:
NCT01580085
First received: April 16, 2012
Last updated: April 17, 2012
Last verified: April 2012

April 16, 2012
April 17, 2012
November 2009
December 2010   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01580085 on ClinicalTrials.gov Archive Site
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Obstructive Sleep Apnea in Pulmonary Embolism
Obstructive Sleep Apnea is Prevalent in Patients With Pulmonary Embolism

Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. Repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. An increased tendency for coagulation has also been reported in OSA. Venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. All of these pathophysiologic changes in OSA may predispose patients for the development of pulmonary embolism (PE) however there is limited data about role of thromboembolic events in OSA.

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Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
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Probability Sample

All subjects admitted to Department of Pulmonary Medicine of Gaziantep University who were diagnosed to have PE were included in the study group. Control group consisted of age and sex matched subjects without a clinic consistent with PE referred to the Sleep Clinic. PE was diagnosed when one or more of the following was present: compatible physical examination findings and multislice CT angiography or presence of deep venous thrombus (DVT) in addition to high risk with Wells criteria [5]. Subjects with any restrictive/obstructive lung pathology or younger than 18 years old were excluded.

  • Pulmonary Thromboembolism
  • Obstructive Sleep Apnea
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG
  • Pulmonary embolism
    Patients who were diagnosed with pulmonary embolism
    Intervention: Other: polysomnography
  • control group
    age and sex matched adults with osa and no thromboembolism
    Intervention: Other: polysomnography
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
75
December 2010
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • All consecutive patients diagnosed with pulmonary embolism

Exclusion Criteria:

  • less than 18 years of age
  • any restrictive or obstructive lung disease
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Turkey
 
NCT01580085
gantep gogus 1
No
meral uyar, University of Gaziantep
University of Gaziantep
Not Provided
Principal Investigator: Meral Uyar, Assist Prof University of Gaziantep
University of Gaziantep
April 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP