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Change in Brain Metabolism and Cognitive Function by Aripiprazole

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Jun Soo Kwon, Seoul National University Hospital
ClinicalTrials.gov Identifier:
NCT01562808
First received: March 22, 2012
Last updated: March 23, 2012
Last verified: March 2012

March 22, 2012
March 23, 2012
January 2009
May 2010   (final data collection date for primary outcome measure)
Reaction time of correct response in N-back task [ Time Frame: 48 hrs after the administration of aripiprazole ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01562808 on ClinicalTrials.gov Archive Site
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Change in Brain Metabolism and Cognitive Function by Aripiprazole
The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.

The investigators explored the relationship between changes in brain metabolism and working memory performance.

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Interventional
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Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
  • Antipsychotics
  • Cognition
  • Brain Metabolism
  • Dopamine Receptor Occupancy
Drug: Aripiprazole
single oral administration of aripiprazole
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Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
15
January 2012
May 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • healthy volunteers
  • right-handed

Exclusion Criteria:

  • any significant abnormality on routine lab
  • any psychiatric disease
Male
19 Years to 30 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT01562808
A070001
No
Jun Soo Kwon, Seoul National University Hospital
Seoul National University Hospital
Not Provided
Principal Investigator: Jun Soo Kwon, M.D., Ph.D. Seoul National University Hospital
Seoul National University Hospital
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP