Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Astragalus Membranaceus in the Patients After Stroke With Fatigue

• EORTC QLQ-C30 [ Time Frame: 2 year(all patients) ] [ Designated as safety issue: Yes ]
• BFI-T score [ Time Frame: 2 years(all patients) ] [ Designated as safety issue: Yes ]

The high levels of fatigue in stroke patients without neurological impairment suggest it has a central origin rather than being the result of increased physical effort required after stroke（Winward et al., 2009）. Fatigue is different from post-stroke depression and the more serious stroke patients are more prone to fatigue（Windward et al., 2009）.

Fatigue is one of the symptoms of qi deficiency,and Astragalus membranaceus is the most effective of all traditional Chinese medicine and can tonifying middle and tonify the original qi. Therefore, the aim of this study was to investigate the efficacy of Astragalus membranaceus on post-stroke fatigue.

• Fatigue
• Stroke

• Drug: Chinese Herb Astragalus membranaceus
  Astragalus membranaceus(AM)at a rate of 2.8g three times per day
• Other: Placebo
  at a rate of 2.8g three times per day

• Experimental: Chinese Herb Astragalus membranaceus
  Intervention: Drug: Chinese Herb Astragalus membranaceus
• Placebo Comparator: Placebo
  Intervention: Other: Placebo

Inclusion Criteria:

1. Gender: Male or female.
2. Age: between 40 and 80 years old.
3. Three months after stroke.
4. Hemorrhagic stroke or ischemic stroke.
5. Fatigue score from screen process ≧4.
6. Subject with comprehension or communication.
7. Volunteer signs the agreement to participate the study after whole study purpose and procedures description in detail.

Exclusion Criteria:

1. People from mental illness can not to participate the evaluation.
2. Major diseases such as cancer、Chronic pulmonary obstructive disease(COPD)、 Heart failure、Myocardial Infraction、Chronic renal failure or Liver cirrhosis.
3. Pregnant woman.
4. Breast-feeding woman.