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Retrospective Analysis of Surgical Outcomes After Corneal Transplantation

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT01547975
First received: March 4, 2012
Last updated: April 1, 2012
Last verified: March 2012
History of Changes

March 4, 2012
April 1, 2012
April 2010
March 2012   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01547975 on ClinicalTrials.gov Archive Site
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Retrospective Analysis of Surgical Outcomes After Corneal Transplantation
Retrospective Analysis of Surgical Outcomes After Corneal Transplantation

Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. National Taiwan University Hospital (NTUH), as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

An insufficient donor supply is a worldwide problem in organ transplantation. Even with corneal transplantations, the most widely performed transplantation, shortages and imbalances in donor supply is a global concern. In National Taiwan University Hospital (NTUH), the investigators performed over one hundred of corneal transplantations every year and the majority of donor corneas were from the eye bank in United States. Previous literature showed satisfactory results in corneal transplantation using foreign donor corneas compared with domestic corneas. However longer preservation time had associated with a statistically significant increased risk of persistence of the postoperative epithelial defect. On the other hand, longer storage times may allow better outcomes in high-risk grafts because of the depletion of donor T cells from the donor cornea into the storage media.

Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. NTUH, as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.
Observational
Observational Model: Case-Crossover
Time Perspective: Retrospective
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Probability Sample

The patients who received corneal transplantation within full chart records.
Corneal Transplantation
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
1000
March 2012
March 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • The patients who received corneal transplantation within full chart records

Exclusion Criteria:

  • The patients have cognitive Impairment.
  • No detail or unclear ophthalmologic record.
  • Patients or their legal representative have no willing to accept this tracing study.
Both
up to 90 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
NCT01547975
201004004R
Yes
National Taiwan University Hospital
National Taiwan University Hospital
Not Provided
Study Chair: Wei-Li Chen, MD,PhD NTUH
National Taiwan University Hospital
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP