The Neural Basis of Lumbosacral Proprioceptive Impairment in Recurrent Low Back Pain
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| First Received Date ICMJE | February 23, 2012 | ||||||||
| Last Updated Date | February 28, 2012 | ||||||||
| Start Date ICMJE | April 2012 | ||||||||
| Estimated Primary Completion Date | December 2014 (final data collection date for primary outcome measure) | ||||||||
| Current Primary Outcome Measures ICMJE | Not Provided | ||||||||
| Original Primary Outcome Measures ICMJE | Not Provided | ||||||||
| Change History | Complete list of historical versions of study NCT01540617 on ClinicalTrials.gov Archive Site | ||||||||
| Current Secondary Outcome Measures ICMJE | Not Provided | ||||||||
| Original Secondary Outcome Measures ICMJE | Not Provided | ||||||||
| Current Other Outcome Measures ICMJE | Not Provided | ||||||||
| Original Other Outcome Measures ICMJE | Not Provided | ||||||||
| Descriptive Information | |||||||||
| Brief Title ICMJE | The Neural Basis of Lumbosacral Proprioceptive Impairment in Recurrent Low Back Pain | ||||||||
| Official Title ICMJE | The Neural Basis of Lumbosacral Proprioceptive Impairment in Recurrent Low Back Pain | ||||||||
| Brief Summary | Low back pain (LBP) is a well known health problem in Western society that is significantly responsible for socio-economic problems like absenteeism and disability. The lifetime prevalence of LBP is 60-80% and approximately 85% of this LBP has a "non-specific" character whereby the underlying causes and risk factors cannot be demonstrated. While many people recover within a month, most individuals will have recurrence within a year with more severe symptoms. This might be due to insufficient knowledge of the underlying mechanisms. Impaired proprioception, the ability to discern body/limb positions and movements, may cause and maintain LBP shown by an altered postural control strategy. Specifically, patients with LBP rely more on proprioceptive signals from the ankles due to less reliable proprioceptive input of proximal segments. Moreover, they show a decreased variability in postural control and less postural robustness, while variability is a prerequisite for optimal functioning of biological systems. However, further clarification of the neural correlates is necessary. Deficits in proprioception, as found in a subgroup of patient with LBP, are associated with a decreased ability of the brain to process proprioceptive inputs. The aim of this project is to clarify the evaluation process (e.g. (re)weighting) of proprioception between the sensory input and the motor output. MRI techniques (fMRI and DTI) will be used for a subgroup of LBP patients with a stereotypic ankle steered postural control and a group of healthy controls to determine brain activation during the application of strictly proprioceptive signals in a well established protocol using air-driven fMRI compatible muscle shakers. |
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| Detailed Description | Not Provided | ||||||||
| Study Type ICMJE | Observational | ||||||||
| Study Design ICMJE | Observational Model: Case Control Time Perspective: Cross-Sectional |
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| Target Follow-Up Duration | Not Provided | ||||||||
| Biospecimen | Not Provided | ||||||||
| Sampling Method | Probability Sample | ||||||||
| Study Population | Leuven and surrounding area |
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| Condition ICMJE | Low Back Pain | ||||||||
| Intervention ICMJE | Not Provided | ||||||||
| Study Group/Cohort (s) |
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| Publications * |
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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| Recruitment Information | |||||||||
| Recruitment Status ICMJE | Not yet recruiting | ||||||||
| Estimated Enrollment ICMJE | 40 | ||||||||
| Estimated Completion Date | March 2015 | ||||||||
| Estimated Primary Completion Date | December 2014 (final data collection date for primary outcome measure) | ||||||||
| Eligibility Criteria ICMJE | Inclusion Criteria persons with low back pain:
Inclusion Criteria healthy persons:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 20 Years to 40 Years | ||||||||
| Accepts Healthy Volunteers | Yes | ||||||||
| Contacts ICMJE |
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| Location Countries ICMJE | Belgium | ||||||||
| Administrative Information | |||||||||
| NCT Number ICMJE | NCT01540617 | ||||||||
| Other Study ID Numbers ICMJE | 2012_SBrumagne_MRIproprio | ||||||||
| Has Data Monitoring Committee | Yes | ||||||||
| Responsible Party | Simon Brumagne, Katholieke Universiteit Leuven | ||||||||
| Study Sponsor ICMJE | Katholieke Universiteit Leuven | ||||||||
| Collaborators ICMJE | Agentschap voor Innovatie door Wetenschap en Technologie | ||||||||
| Investigators ICMJE |
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| Information Provided By | Katholieke Universiteit Leuven | ||||||||
| Verification Date | February 2012 | ||||||||
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ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |
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