Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Procalcitonin Monitoring Sepsis Study (MOSES)

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2013 by Brahms AG
Information provided by (Responsible Party):
Brahms AG Identifier:
First received: January 19, 2012
Last updated: November 21, 2013
Last verified: November 2013

January 19, 2012
November 21, 2013
December 2011
January 2014   (final data collection date for primary outcome measure)
28 day all cause mortality [ Time Frame: within 28 day safter inlclusion ] [ Designated as safety issue: No ]
participants will be followed up for 28 days
all cause in-hospital mortality [ Time Frame: duration of hospital stay up to 10 days ] [ Designated as safety issue: No ]
participants will be followed for the duration of hospital stay, an expected average of 10 days
Complete list of historical versions of study NCT01523717 on Archive Site
all-cause in-hospital mortality [ Time Frame: mortality during hospital stay ] [ Designated as safety issue: No ]
count all death through out stay in the hospital
28 days mortality [ Time Frame: 28 days after enrolment ] [ Designated as safety issue: No ]
all cause death will be assessed within 28 days after enrolment
Not Provided
Not Provided
Procalcitonin Monitoring Sepsis Study
Procalcitonin Decrease Over 72 Hours and Outcome in Patients With Severe Sepsis or Septic Shock

The purpose of this study is to investigate the relationship between a procalcitonin decrease over 72 hours and outcome in patients who have severe sepsis or septic shock.

Not Provided
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample

adult patients with severe sepsis or septic shock in the emergency department, medical floor, ICU

  • Severe Sepsis
  • Septic Shock
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
July 2014
January 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adult patients (i.e. >18 years of age) diagnosed with severe sepsis or septic shock as defined in Appendix 1, who are already in the ICU or come from the ED, other wards or directly from out of hospital
  • Blood sample collection within 12 hours after diagnosis "severe sepsis or septic shock"No prior enrollment into this study
  • Written informed consent
18 Years and older
United States
Not Provided
Brahms AG
Brahms AG
Not Provided
Principal Investigator: Nathan Shapiro, MD Beth Israel Deaconess Medical Center
Brahms AG
November 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP