Imaging Outcomes of Cognitive Behavioral Therapy (CBT) for Battered Women With Posttraumatic Stress Disorder

This study has been completed.
Sponsor:
Collaborator:
San Diego Veterans Healthcare System
Information provided by (Responsible Party):
Murray B. Stein, University of California, San Diego
ClinicalTrials.gov Identifier:
NCT01517672
First received: January 16, 2012
Last updated: January 21, 2012
Last verified: January 2012

January 16, 2012
January 21, 2012
January 2008
December 2010   (final data collection date for primary outcome measure)
Clinician-Administered PTSD Scale (CAPS) [ Time Frame: After 10 sessions of cognitive behavioral therapy (CBT) (10-14 weeks) ] [ Designated as safety issue: No ]
The CAPS is a widely used measure of PTSD severity. Intent was to administer 10 sessions of CBT over a period of 10-14 weeks. Primary outcome was CAPS at the end of CBT administration.
Same as current
Complete list of historical versions of study NCT01517672 on ClinicalTrials.gov Archive Site
CAPS 3 months post-treatment [ Time Frame: 3 months post-treatment ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Imaging Outcomes of Cognitive Behavioral Therapy (CBT) for Battered Women With Posttraumatic Stress Disorder
Neurobiology of Severe Psychological Trauma in Women

Identifying neural mechanisms of posttraumatic stress disorder (PTSD) treatment could help elucidate reasons for variable treatment response and identify novel treatment targets. Exposure-based therapies have been associated with decreased amygdala and increased cingulate cortex response during emotional processing. The current study examined whether cognitive therapy for PTSD in women reduces activation in insula and amygdala and enhances activation in prefrontal regions during emotional anticipation and pre-treatment prefrontal activation predicts treatment response.

Not Provided
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Posttraumatic Stress Disorder
Behavioral: Cognitive Trauma Therapy for Battered Women (CTT-BW)
10 individual sessions of this form of cognitive therapy, with a trained therapist.
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
41
December 2010
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Female.
  • Intimate partner violence (IPV) trauma defined as physical and/or sexual abuse committed by a romantic partner, occurring within five years of, but having ended at least one month prior to, enrollment in the study.
  • Seeking treatment for posttraumatic stress disorder (PTSD) symptoms and meeting full or partial Diagnostic and Statistical Manual, 4th edition (DSM-IV) criteria for PTSD prior to treatment, verified through the Clinician-Administered PTSD Scale (CAPS).

Exclusion Criteria:

  • Substance abuse in the past year
  • History of >2 years of alcohol abuse
  • Use of psychotropic medications within 4 weeks prior to the study, bipolar disorder or schizophrenia, irremovable ferromagnetic bodily material, pregnancy, or claustrophobia.
Female
18 Years to 60 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01517672
STEIN VA MERIT
No
Murray B. Stein, University of California, San Diego
University of California, San Diego
San Diego Veterans Healthcare System
Principal Investigator: Murray B Stein, MD, MPH University of California, San Diego
University of California, San Diego
January 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP