Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation

This study is ongoing, but not recruiting participants.

Sponsor:

Information provided by (Responsible Party):

Norwegian University of Science and Technology

ClinicalTrials.gov Identifier:

NCT01493128

First received: December 13, 2011

Last updated: December 14, 2011

Last verified: December 2011

History of Changes

Tracking Information

First Received Date ^ICMJE

December 13, 2011

Last Updated Date

December 14, 2011

Start Date ^ICMJE

April 2010

Estimated Primary Completion Date

February 2012 (final data collection date for primary outcome measure)

Current Primary Outcome Measures ^ICMJE

Not Provided

Original Primary Outcome Measures ^ICMJE

Not Provided

Change History

Complete list of historical versions of study NCT01493128 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Not Provided

Original Secondary Outcome Measures ^ICMJE

Not Provided

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation

Official Title ^ICMJE

Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation

Brief Summary

The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since there exist no current information on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF) the investigators sought to determine whether a regulation of these proteins may be an underlying cause of the disease. Mitochondrial function will also studied.

The investigators hypothesize that structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared to patients in sinus rhythm.
The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared to patients in sinus rhythm.

Detailed Description

Not Provided

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Observational Model: Case Control
Time Perspective: Cross-Sectional

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: Samples Without DNA

Description:

Myocardial tissue from the right and left atrial appendage.

Sampling Method

Non-Probability Sample

Study Population

Samples were obtained with written informed consent from the right and left atrial appendage, during open heart surgery from patients in sinus rhythm, with permanent AF and paroxysmal AF.

Condition ^ICMJE

Atrial Fibrillation

Intervention ^ICMJE

Not Provided

Study Group/Cohort (s)

stable sinus rhythm
permanent atrial fibrillation
paroxysmal atrial fibrillation

Publications *

Not Provided

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Active, not recruiting

Estimated Enrollment ^ICMJE

Estimated Completion Date

February 2012

Estimated Primary Completion Date

February 2012 (final data collection date for primary outcome measure)

Eligibility Criteria ^ICMJE

Inclusion Criteria:

sinus rhythm, permanent atrial fibrillation or paroxysmal atrial fibrillation
selected for open heart surgery

Exclusion Criteria:

not given informed consent

Gender

Both

Ages

50 Years to 85 Years

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Not Provided

Administrative Information

NCT Number ^ICMJE

NCT01493128

Other Study ID Numbers ^ICMJE

ABJ01

Has Data Monitoring Committee

Responsible Party

Norwegian University of Science and Technology

Study Sponsor ^ICMJE

Norwegian University of Science and Technology

Collaborators ^ICMJE

Not Provided

Investigators ^ICMJE

Study Director:

Ulrik Wisløff, PhD

Norwegian University of Science and Technology

Information Provided By

Norwegian University of Science and Technology

Verification Date

December 2011

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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