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TREM-1 Gene Polymorphisms

This study has been completed.
Sponsor:
Information provided by:
Chinese PLA General Hospital
ClinicalTrials.gov Identifier:
NCT01490424
First received: December 12, 2011
Last updated: NA
Last verified: December 2011
History: No changes posted

December 12, 2011
December 12, 2011
May 2010
October 2011   (final data collection date for primary outcome measure)
Patients Outcome [ Time Frame: 28 days ] [ Designated as safety issue: No ]
The survival time of patients more than 28days is defined as survival. The survival time of patients less than 28days is defined as death
Same as current
No Changes Posted
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TREM-1 Gene Polymorphisms
Association Between TREM-1 Gene Polymorphisms and Prognosis in Sepsis Patient

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. Blocking of TREM-1 can protect against sepsis in mice. This study was designed to investigate whether TREM-1 genomic variations were associated with the prognosis of sepsis. We sequenced 30 sepsis patients with TREM-1 gene of four exons by PCR sequencing. When analyzing the results of sequencing, we found two gene polymorphisms located in exon-2 and exon-4, respectively. Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246. Two common polymorphisms (rs2234237,rs2234246) within the TREM-1 gene were detected in 80 patients with severe sepsis and in 80 healthy control subjects. This study was explored that whether or not polymorphisms detected within the TREM-1 gene may play a major role in the predisposition to prognosis of sepsis in a Chinese Han cohort.

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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Probability Sample

All subjects were selected from among inpatients who were hospitalized between September 2009 and October 2011 in the Respiratory ICU, Surgical ICU, and Emergency ICU, Chinese People's Liberation Army (CPLA) General Hospital.

Sepsis
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  • sepsis
    SIRS plus inflammation
  • Control
    normal person under medical examination
Su L, Liu C, Li C, Jiang Z, Xiao K, Zhang X, Li M, Yan P, Feng D, Xie L. Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis. Inflammation. 2012 Dec;35(6):1833-43. doi: 10.1007/s10753-012-9504-z.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
160
October 2011
October 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Sepsis met the criteria recommended by 1991 ACCP/SCCM Joint Meeting and by the diagnostic criteria developed at the 2001 International Sepsis Definition Conference.

Exclusion Criteria:

  • (1) younger than 18 years of age; (2) acquired immunodeficiency syndrome; (3) reduced polymorphonuclear granulocyte counts (< 500 μL-1); (4) died within 24h after admission into the ICU, or refused to participate in the study, or declined treatment during the period of observation.
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
China
 
NCT01490424
20111013-009(2), 2009BAI86B03
No
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Chinese PLA General Hospital
Not Provided
Study Director: Lixin Xie, MD Respiratory Disease Department of chinese PLA General Hospital
Chinese PLA General Hospital
December 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP