Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Antonio A.M. Castro, Federal University of São Paulo

ClinicalTrials.gov Identifier:

NCT01475812

First received: November 17, 2011

Last updated: November 18, 2011

Last verified: November 2011

History of Changes

Tracking Information
First Received Date ^ICMJE	November 17, 2011
Last Updated Date	November 18, 2011
Start Date ^ICMJE	March 2007
Primary Completion Date	Not Provided
Current Primary Outcome Measures ^ICMJE (submitted: November 18, 2011)	Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients. [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Original Primary Outcome Measures ^ICMJE	Same as current
Change History	Complete list of historical versions of study NCT01475812 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures ^ICMJE	Not Provided
Original Secondary Outcome Measures ^ICMJE	Not Provided
Current Other Outcome Measures ^ICMJE	Not Provided
Original Other Outcome Measures ^ICMJE	Not Provided

Descriptive Information
Brief Title ^ICMJE	Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients
Official Title ^ICMJE	Not Provided
Brief Summary	Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).
Detailed Description	Not Provided
Study Type ^ICMJE	Observational
Study Design ^ICMJE	Time Perspective: Cross-Sectional
Target Follow-Up Duration	Not Provided
Biospecimen	Not Provided
Sampling Method	Probability Sample
Study Population	The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.
Condition ^ICMJE	Dynamic Lung Hyperinflation COPD Patients Activities of Daily Livin.
Intervention ^ICMJE	Other: Hyperinflation and ADL Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.
Study Group/Cohort (s)	COPD hyperinflation Intervention: Other: Hyperinflation and ADL
Publications *	Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Completed
Enrollment ^ICMJE	19
Completion Date	Not Provided
Primary Completion Date	Not Provided
Eligibility Criteria ^ICMJE	Inclusion Criteria: COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9) clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form Exclusion Criteria: Inability to perform the slow vital capacity maneuver excessive perceived dyspnea during the test arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation
Gender	Both
Ages	50 Years to 80 Years
Accepts Healthy Volunteers	No
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE	Brazil

Administrative Information
NCT Number ^ICMJE	NCT01475812
Other Study ID Numbers ^ICMJE	0353/03
Has Data Monitoring Committee	No
Responsible Party	Antonio A.M. Castro, Federal University of São Paulo
Study Sponsor ^ICMJE	Federal University of São Paulo
Collaborators ^ICMJE	Not Provided
Investigators ^ICMJE	Not Provided
Information Provided By	Federal University of São Paulo
Verification Date	November 2011
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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