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Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Antonio A.M. Castro, Federal University of São Paulo
ClinicalTrials.gov Identifier:
NCT01475812
First received: November 17, 2011
Last updated: November 18, 2011
Last verified: November 2011

November 17, 2011
November 18, 2011
March 2007
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Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients. [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01475812 on ClinicalTrials.gov Archive Site
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Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients
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Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

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Observational
Time Perspective: Cross-Sectional
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Probability Sample

The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.

  • Dynamic Lung Hyperinflation
  • COPD Patients
  • Activities of Daily Livin.
Other: Hyperinflation and ADL
Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.
COPD hyperinflation
Intervention: Other: Hyperinflation and ADL
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
19
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Inclusion Criteria:

  • COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
  • clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

Exclusion Criteria:

  • Inability to perform the slow vital capacity maneuver
  • excessive perceived dyspnea during the test
  • arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation
Both
50 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT01475812
0353/03
No
Antonio A.M. Castro, Federal University of São Paulo
Federal University of São Paulo
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Federal University of São Paulo
November 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP