Prognostic Factor Analysis in Metastatic Esophageal Squamous Cell Carcinoma

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Jeeyun Lee, Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT01472419
First received: November 11, 2011
Last updated: April 7, 2013
Last verified: April 2013

November 11, 2011
April 7, 2013
March 2012
December 2012   (final data collection date for primary outcome measure)
Overall Survival [ Time Frame: 12 month ] [ Designated as safety issue: Yes ]
Same as current
Complete list of historical versions of study NCT01472419 on ClinicalTrials.gov Archive Site
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Prognostic Factor Analysis in Metastatic Esophageal Squamous Cell Carcinoma
Fluoropyrimidine/Platinum-based First-line Chemotherapy in Metastatic Esophageal Squamous Cell Carcinoma: Prognostic Factor Analysis in 239 Patients

Esophageal squamous cell carcinoma is considerably more prevalent in East Asia. Despite of relatively high prevalence of esophageal SCC, prognosis is very poor with limited options of effective chemotherapy regimens. We attempted to identify favorable subgroups of patient who are likely to benefit from 5- fluorouracil/cisplatin(FP) or capecitabine/cisplatin (XP) chemotherapy as first-line treatment.Between January 2000 to December 2010, 239 patients were diagnosed of recurrent, metastatic esophageal SCC and received either FP or XP as first-line chemotherapy. Clinicopathologic variables and treatment outcome were retrospectively collected. we analysis treatment outcome of palliative chemotherapy in metastatic esophageal squamous cell carcinoma and make prognostic scoring system. The present study represents the largest series to analyze the treatment outcome of FP/XP chemotherapy in metastatic SCC. Risk-adapted stratification of treatment for subgroup of metastatic SCC patients should be actively pursued.

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Observational
Time Perspective: Retrospective
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Probability Sample

Between January 2000 to December 2010, 239 patients were diagnosed of recurrent, metastatic esophageal SCC and received either FP or XP as first-line chemotherapy.

Metastatic Esophageal Squamous Cell Carcinoma
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
239
March 2013
December 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • recurrent, metastatic esophageal SCC
  • received either FP or XP as first-line chemotherapy.

Exclusion Criteria:

Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
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NCT01472419
SMCESOPROGNOSIS
No
Jeeyun Lee, Samsung Medical Center
Samsung Medical Center
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Principal Investigator: Jeeyun Lee, M.D., Ph.D. Samsung Medical Center, Seoul, Korea
Samsung Medical Center
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP