Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome (ProgBBN)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Bollmann Bruckner Noss
ClinicalTrials.gov Identifier:
NCT01426152
First received: August 28, 2011
Last updated: August 29, 2011
Last verified: August 2011

August 28, 2011
August 29, 2011
January 2006
April 2011   (final data collection date for primary outcome measure)
Ongoing pregnancy rate [ Time Frame: 13 weeks ] [ Designated as safety issue: No ]
Patients will be followed up from embryotransfer until second trimester of pregnancy
Same as current
Complete list of historical versions of study NCT01426152 on ClinicalTrials.gov Archive Site
Delivery after 23.gestational weeks [ Time Frame: 9 months ] [ Designated as safety issue: No ]
Patients will be followed up from embryotransfer until delivery
Same as current
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Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome
Association Between Progesterone Levels on the Day of Ovulation Induction and IVF Outcome: Retrospective Study With 2500 Controlled Ovarian Stimulations Cycles

Progesterone levels measured in blood/serum of patients on the day of ovulation induction following controlled ovarian stimulation for in vitro fertilization may be associated with pregnancy outcome. The hypothesis is that higher progesterone levels are associated with lower implantation rates due to changes in the endometrial receptivity.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Retrospective
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Probability Sample

Female patients with infertility undergoing assisted reproduction techniques, i.e. in vitro fertilization.

Female Infertility
Not Provided
  • Low level progesterone group (1)
    Progesterone < 1.50 ng/mL on day of ovulation induction
  • Medium level progesterone group (2)
    Progesterone 1.51-1.99 ng/mL on the day of ovulation induction
  • High level progesterone group (3)
    Progesterone > 1.99 ng/mL on the day of ovulation induction
Ochsenkühn R, Arzberger A, von Schönfeldt V, Gallwas J, Rogenhofer N, Crispin A, Thaler CJ, Noss U. Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers. Fertil Steril. 2012 Aug;98(2):347-54. doi: 10.1016/j.fertnstert.2012.04.041. Epub 2012 May 24.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
2555
April 2011
April 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • IVF/ICSI following controlled ovarian stimulation
  • progesterone measured on the day of ovulation induction
  • informed consent

Exclusion Criteria:

  • missing consent
Female
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT01426152
Prog2006-2011, BBN
Yes
Bollmann Bruckner Noss
Bollmann Bruckner Noss
Not Provided
Principal Investigator: Robert Ochsenkuehn, MD Center for Reproductive Medicine
Bollmann Bruckner Noss
August 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP