Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2011 by Southern Medical University, China.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Southern Medical University, China
ClinicalTrials.gov Identifier:
NCT01406041
First received: July 28, 2011
Last updated: NA
Last verified: April 2011
History: No changes posted

July 28, 2011
July 28, 2011
February 2011
January 2013   (final data collection date for primary outcome measure)
Blood sodium [ Time Frame: 24 hours ] [ Designated as safety issue: Yes ]
Normal: 135~155
Same as current
No Changes Posted
Urine sodium [ Time Frame: 24 hours ] [ Designated as safety issue: Yes ]
Same as current
Not Provided
Not Provided
 
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
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The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions. Moreover, if the patients are undergone the surgery for remove the lesion, FEI happens in all cases without exception. Hypo- and hyper-natremia is the most common electrolyte disorder, which is directly correlated to the patients' outcome. However, in clinical works, different sellar diseases cause variant features of FEI. For example, after the surgery of craniopharyngioma, the hyponatremia and hypernatremia always happen alternatively even without any precursor manifestation. Under this situation, it is quite difficult for fluid supplement. In contrast, the severe FEI will cause poor outcome, even death. So it is necessary to systematically collect and review the clinical data of sellar lesions. Through the analysis of variant FEI patterns of sellar diseases, more precise strategy for clinical fluid replacement will be proposed.

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Observational
Observational Model: Case-Only
Time Perspective: Retrospective
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Probability Sample

All patients presented in our department suffered with sellar diseases

  • The Patients Suffered With Sellar Diseases
  • The Fluid and Electrolyte Imbalance Happened After Surgery
Biological: Chemical and physical detection
CVP, Urine volume per day, Blood electrolytes, Urine sodium per day, Pituitrin
Diseases
1. Pituitary adenomas; 2. Craniopharyngioma; 3. Sellar germinoma; 4. Sellar tuberalis meningioma; 5. Hypophystis; 6. Sellar glioma; 7. Rathke's cleft cyst; 8. Hypothalamic hamartoma
Intervention: Biological: Chemical and physical detection
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
350
January 2014
January 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 1. Suffered with sellar disease
  • 2. Udergone surgery
  • 3. Have sufficient presurgical and postsurgical clinical data (Including MRI, CT, physical and chemical detection results)

Exclusion Criteria:

  • 1. Without sufficitent clincal data
  • 2. No surgery
Both
Not Provided
No
Contact: Yuntao Lu, PI +86-13632101002 lllu2000yun@gmail.com
China
 
NCT01406041
The department of Neurosurgery
Yes
Yuntao Lu/principal investigator, The department of neurosurgery
Southern Medical University, China
Not Provided
Not Provided
Southern Medical University, China
April 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP