The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

This study is ongoing, but not recruiting participants.

Sponsor:

Information provided by:

Meir Medical Center

ClinicalTrials.gov Identifier:

NCT01384136

First received: June 27, 2011

Last updated: NA

Last verified: June 2011

History: No changes posted

Tracking Information
First Received Date ^ICMJE	June 27, 2011
Last Updated Date	June 27, 2011
Start Date ^ICMJE	June 2011
Estimated Primary Completion Date	June 2015 (final data collection date for primary outcome measure)
Current Primary Outcome Measures ^ICMJE	Not Provided
Original Primary Outcome Measures ^ICMJE	Not Provided
Change History	No Changes Posted
Current Secondary Outcome Measures ^ICMJE	Not Provided
Original Secondary Outcome Measures ^ICMJE	Not Provided
Current Other Outcome Measures ^ICMJE	Not Provided
Original Other Outcome Measures ^ICMJE	Not Provided

Descriptive Information
Brief Title ^ICMJE	The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies
Official Title ^ICMJE	The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies
Brief Summary	The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress. The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes. The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.
Detailed Description	Not Provided
Study Type ^ICMJE	Observational
Study Design ^ICMJE	Observational Model: Case Control Time Perspective: Cross-Sectional
Target Follow-Up Duration	Not Provided
Biospecimen	Not Provided
Sampling Method	Non-Probability Sample
Study Population	High risk pregnancies, third trimester, after the delivery/
Condition ^ICMJE	Telomere Length Mechanisms of Telomter Homeostasis High Risk Pregnancies
Intervention ^ICMJE	Not Provided
Study Group/Cohort (s)	High risk pregnancy /Control - Normal low risk pregnancies
Publications *	Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Active, not recruiting
Estimated Enrollment ^ICMJE	100
Estimated Completion Date	June 2015
Estimated Primary Completion Date	June 2015 (final data collection date for primary outcome measure)
Eligibility Criteria ^ICMJE	Inclusion Criteria: Third trimester post delivery Intrauterine growth restriction Preeclampsia Diabetes Control - low risk normal pregnancies Exclusion Criteria: Patients who do not want to participate Known HIV or Hepatitis
Gender	Female
Ages	18 Years to 45 Years
Accepts Healthy Volunteers	Yes
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE	Israel

Administrative Information
NCT Number ^ICMJE	NCT01384136
Other Study ID Numbers ^ICMJE	036-2011 MMC
Has Data Monitoring Committee	Yes
Responsible Party	Tal Biron-Shental, Meir Medical Center, Kfar Saba, Israel
Study Sponsor ^ICMJE	Meir Medical Center
Collaborators ^ICMJE	Not Provided
Investigators ^ICMJE	Not Provided
Information Provided By	Meir Medical Center
Verification Date	June 2011
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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