MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
NICOR/MINAP, the United Kingdom
NICOR: National Institute for Cardiac Outcomes Research
MINAP: Myocardial Ischaemia National Audit Project
SWEDEHEART/RIKS-HIA, Sweden
SWEDEHEART: Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies
RIKS-HIA: Register of Information and Knowledge about Swedish Heart Intensive care Admissions
Information provided by (Responsible Party):
University College, London
ClinicalTrials.gov Identifier:
NCT01359033
First received: May 23, 2011
Last updated: February 3, 2014
Last verified: February 2014

May 23, 2011
February 3, 2014
March 2011
December 2014   (final data collection date for primary outcome measure)
30-day mortality [ Time Frame: 30-day ] [ Designated as safety issue: No ]
all-cause mortality at 30-day following hospitalization for acute Myocardial Infarction
Same as current
Complete list of historical versions of study NCT01359033 on ClinicalTrials.gov Archive Site
1-year mortality [ Time Frame: 1 year ] [ Designated as safety issue: No ]
all-cause mortality at 1-year following hospitalization for acute Myocardial Infarction
Same as current
Not Provided
Not Provided
 
MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden
Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden

The study aims to investigate the differences in survival trajectories and hospital variability in myocardial infarction (MI) mortality rates in the UK and Sweden.

Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden.

The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.

Observational
Observational Model: Cohort
Time Perspective: Retrospective
Not Provided
Not Provided
Non-Probability Sample

For the UK, all patients with an admission recorded in the MINAP database during 1st January 2004 and 31 December 2008 in 253 hospitals in England and Wales will be included in the study. For Sweden, all patients with an admission recorded in the RIKS-HIA during 1st January 2004 and 31 December 2008 in 74 hospitals in Sweden will be included. Only patients with acute myocardial infarction will be included as the study population.

Acute Myocardial Infarction
Not Provided
  • MINAP cohort
    The Myocardial Ischaemia National Audit Project (MINAP) was established in 1999, in response to the national service framework (NSF) for coronary heart disease, to examine the quality of management of heart attacks (myocardial infarction) in hospitals in England and Wales.
  • RIKS-HIA cohort
    The Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) has been established to record clinical and treatment information for all patients admitted to the coronary care units in Sweden from 1995.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
370000
December 2020
December 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients aged above 30 years old who had hospital admission for acute myocardial infarction.
  • Admission period ranged from 1st January, 2004 to 31th December, 2008.

Exclusion Criteria:

  • Patients with missing data in the admission time and/or primary outcomes.
Both
30 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Sweden,   United Kingdom
 
NCT01359033
FP7-EIS-WP7-MINAP
Yes
University College, London
University College, London
  • NICOR/MINAP, the United Kingdom
  • NICOR: National Institute for Cardiac Outcomes Research
  • MINAP: Myocardial Ischaemia National Audit Project
  • SWEDEHEART/RIKS-HIA, Sweden
  • SWEDEHEART: Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies
  • RIKS-HIA: Register of Information and Knowledge about Swedish Heart Intensive care Admissions
Principal Investigator: Sheng-Chia Chung, Ph.D University College, London
University College, London
February 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP