Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Yonsei University
ClinicalTrials.gov Identifier:
NCT01351285
First received: May 4, 2011
Last updated: June 1, 2013
Last verified: June 2013

May 4, 2011
June 1, 2013
April 2011
October 2011   (final data collection date for primary outcome measure)
occurrence of cough [ Time Frame: From the completion of surgery to 5minute after extubation ] [ Designated as safety issue: No ]
We will assess the occurrence of cough during emergence from general anesthesia in female patients undergoing target controlled infusion of remifentanil at predetemined concentration.
Same as current
Complete list of historical versions of study NCT01351285 on ClinicalTrials.gov Archive Site
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Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)
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It has been reported that target-controlled infusion of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. We hypothesized that effective concentration of remifentanil for preventing cough during anesthetic emergence varies depending on the type of main anesthetic agents which is administered with remifentanil during general anesthesia. The purpose of this study is to evaluate the effective concentrations of remifentanil to prevent coughing during emergence from general anesthesia according to main anesthetic agent (sevoflurane, desflurane, and propofol).

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Interventional
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Allocation: Randomized
Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Female Patients Undergoing Thyroidectomy
Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
During the emergence from anesthesia, if the patient did not cough, the extubation was defined as smooth emergence and the predetermined effect site concentration of remifentanil for the subsequent patient was decreased by 0.5 ng/mL. Likewise, if the patient coughed anytime around extubation, it was considered a failed smooth emergence and the predetermined effect site concentration for the next patient was increased by 0.5 ng/mL. This up-and-down method was conducted independently for each of the three groups. EC50 of the remifentanil of each group was obtained using the Dixon's method.
  • Experimental: Sevo group
    undergoing sevoflurane-remifentanil anesthesia
    Intervention: Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
  • Active Comparator: Des group
    undergoing desflurane-remifentanil anesthesia
    Intervention: Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
  • Active Comparator: Pro group
    undergoing propofol-remifentanil anesthesia
    Intervention: Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
78
October 2011
October 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • aged 20-60
  • ASA classification I~II
  • female patients
  • patients who undergoing thyroidectomy

Exclusion Criteria:

  • Patients with acute or chronic respiratory disease
  • patient who has smoking history
  • patient who has hypertension
  • patient who has esophageal reflux
  • patient who having an expectorant or cough remedy
Female
20 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT01351285
4-2011-0019
No
Yonsei University
Yonsei University
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Yonsei University
June 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP