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Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Humberto Nicastro, University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT01350427
First received: May 2, 2011
Last updated: February 22, 2013
Last verified: February 2013
History of Changes

May 2, 2011
February 22, 2013
August 2011
February 2013   (final data collection date for primary outcome measure)
  • Protein synthesis [ Time Frame: 1 hour ] [ Designated as safety issue: Yes ]
    Phosphorylation of proteins involved in protein synthesis
  • Protein degradation [ Time Frame: 1 hour ] [ Designated as safety issue: Yes ]
    Expression of protein involved in proteolytic pathway
  • Inflammation [ Time Frame: 1 hour ] [ Designated as safety issue: Yes ]
    Expression of systemic and muscular cytokines
Same as current
Complete list of historical versions of study NCT01350427 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways
Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study

This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Healthy
  • Dietary Supplement: Leucine supplementation
    1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine
  • Dietary Supplement: BCAA supplementation
    1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine
  • Dietary Supplement: Alanine supplementation
    1 bout of resistance exercise and supplementation of 9.6 g of alanine
  • Experimental: Leucine
    Intervention: Dietary Supplement: Leucine supplementation
  • Experimental: BCAA
    Intervention: Dietary Supplement: BCAA supplementation
  • Placebo Comparator: Placebo
    Intervention: Dietary Supplement: Alanine supplementation
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
18
February 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Sedentaries
  • Must be able to exercise
  • Must be able to swallow tablets

Exclusion Criteria:

  • Use of nutritional supplements
  • Use of anti-inflammatory drugs
Male
18 Years to 30 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT01350427
2011/04690-6
Yes
Humberto Nicastro, University of Sao Paulo
University of Sao Paulo
Not Provided
Principal Investigator: Claudia R da Luz, Master Student University of São Paulo
University of Sao Paulo
February 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP