Rebreathing of Carbon Dioxide With a Device Used for Giving Inhalational Anaesthesia

This study is currently recruiting participants.
Verified February 2014 by Region Skane
Sponsor:
Information provided by (Responsible Party):
Region Skane
ClinicalTrials.gov Identifier:
NCT01339013
First received: April 13, 2011
Last updated: March 4, 2014
Last verified: February 2014

April 13, 2011
March 4, 2014
April 2011
March 2014   (final data collection date for primary outcome measure)
Quantification of ventilation requirements with the use of the AnaConDa rebreathing system for anesthetic gases [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Changes to tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value.
Quantification of ventilation requirements with the use of the AnaConDa rebreathing system for anesthetic gases [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Changes to tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume.
Complete list of historical versions of study NCT01339013 on ClinicalTrials.gov Archive Site
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Rebreathing of Carbon Dioxide With a Device Used for Giving Inhalational Anaesthesia
Dead Space Effect of an Anaesthesia Gas Reflector (AnaConDa)

The anesthesia gas reflector (AnaConDa) is built on the adsorptive capacity of active carbon which also adsorbs carbon dioxide in exhaled air. Rebreathing of carbon dioxide thus occurs and must be compensated for by increased ventilation. This study aims at determining how much compensation must be given, based on the hypothesis that rebreathing depends on carbon dioxide level in blood and exhaled air.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Anesthetic Ventilatory Requirements
Device: Anesthetic Conserving Device (AnaConDa )
Active AnaConDa has charcoal filter, inactive does not.
  • Active Comparator: Active AnaConDa
    Intervention: Device: Anesthetic Conserving Device (AnaConDa )
  • Active Comparator: Inactive AnaConDa
    Intervention: Device: Anesthetic Conserving Device (AnaConDa )
Sturesson LW, Bodelsson M, Johansson A, Jonson B, Malmkvist G. Apparent dead space with the anesthetic conserving device, AnaConDa®: a clinical and laboratory investigation. Anesth Analg. 2013 Dec;117(6):1319-24. doi: 10.1213/ANE.0b013e3182a7778e.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
12
April 2014
March 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • elective coronary artery by-pass graft surgery
  • elective valve replacement surgery
  • normal left ventricular ejection fraction on preoperative echocardiography

Exclusion Criteria:

  • obstructive lung disease
  • restrictive lung disease
Both
18 Years and older
No
Contact: Gunnar Malmkvist, M.D., Ph.D. +46 46 171035
Sweden
 
NCT01339013
20110322
No
Region Skane
Region Skane
Not Provided
Principal Investigator: Mikael Bodelsson, Professor Division of Surgery, Department of Anaesthesia, Skane University Hospital, Lund, Sweden
Region Skane
February 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP